0 8 Evidence evidence NN 9 12 for for IN 13 14 a a DT 15 27 trans-acting trans-acting JJ 28 37 activator activator NN 38 46 function function NN 47 57 regulating regulate VBG 58 61 the the DT 62 72 expression expression NN 73 75 of of IN 76 79 the the DT 80 85 human human JJ 86 89 CD5 cd5 NN 90 97 antigen antigen NN 97 98 . . . 100 112 Interspecies interspecies JJ 113 120 somatic somatic JJ 121 125 cell cell NN 126 133 hybrids hybrid NNS 134 138 were be VBD 139 148 generated generate VBN 149 151 by by IN 152 158 fusing fuse VBG 159 162 the the DT 163 168 mouse mouse NN 169 179 T-lymphoma T-lymphoma NNP 180 184 cell cell NN 185 189 line line NN 189 190 , , , 191 197 BW5147 BW5147 NNP 197 198 , , , 199 203 with with IN 204 210 normal normal JJ 211 216 human human JJ 217 218 T t NN 219 230 lymphocytes lymphocyte NNS 231 233 at at IN 234 243 different different JJ 244 250 stages stage NNS 251 253 of of IN 254 269 differentiation differentiation NN 269 270 . . . 271 281 Thymocytes Thymocyte NNP 281 282 , , , 283 292 activated activate VBN 293 303 peripheral peripheral JJ 304 305 T t NN 306 317 lymphocytes lymphocyte NNS 317 318 , , , 319 321 or or CC 322 324 an an DT 325 334 activated activate VBN 335 341 T-cell t-cell NN 342 347 clone clone NN 348 352 were be VBD 353 357 used use VBN 358 360 as as IN 361 366 human human JJ 367 375 partners partner NNS 375 376 , , , 377 389 respectively respectively RB 389 390 , , , 391 393 in in IN 394 399 three three CD 400 411 independent independent JJ 412 419 fusions fusion NNS 419 420 . . . 421 433 Irrespective irrespective JJ 434 436 of of IN 437 440 the the DT 441 446 human human JJ 447 451 cell cell NN 452 459 partner partner NN 460 464 used use VBN 465 468 for for IN 469 475 fusion fusion NN 475 476 , , , 477 478 a a DT 479 486 certain certain JJ 487 493 number number NN 494 496 of of IN 497 504 hybrids hybrid NNS 505 509 lost lose VBD 510 513 CD5 CD5 NNP 514 521 surface surface NN 522 532 expression expression NN 533 537 over over IN 538 539 a a DT 540 546 period period NN 547 549 of of IN 550 554 time time NN 555 557 in in IN 558 565 culture culture NN 565 566 . . . 567 575 Analysis Analysis NNP 576 578 at at IN 579 582 the the DT 583 592 phenotype phenotype NN 593 596 and and CC 597 604 genetic genetic JJ 605 610 level level NN 611 617 showed show VBD 618 622 that that IN 623 627 lack lack NN 628 630 of of IN 631 634 CD5 CD5 NNP 635 645 expression expression NN 646 649 was be VBD 650 653 due due JJ 654 661 neither neither CC 662 664 to to TO 665 676 segregation segregation NN 677 679 of of IN 680 685 human human JJ 686 694 autosome autosome NN 695 697 11 11 CD 697 698 , , , 699 701 on on IN 702 707 which which WDT 708 711 the the DT 712 715 CD5 CD5 NNP 716 720 gene gene NN 721 724 has have VBZ 725 729 been be VBN 730 736 mapped map VBN 736 737 , , , 738 741 nor nor CC 742 744 to to TO 745 753 deletion deletion NN 754 756 of of IN 757 760 the the DT 761 764 CD5 CD5 NNP 765 775 structural structural JJ 776 780 gene gene NN 780 781 . . . 782 793 Furthermore furthermore RB 793 794 , , , 795 799 loss loss NN 800 802 of of IN 803 806 CD5 CD5 NNP 807 814 surface surface NN 815 825 expression expression NN 826 836 correlated correlate VBD 837 841 with with IN 842 845 the the DT 846 853 absence absence NN 854 856 of of IN 857 865 specific specific JJ 866 870 mRNA mrna NN 870 871 . . . 872 877 Since since IN 878 883 these these DT 884 891 hybrids hybrid NNS 892 906 preferentially preferentially RB 907 916 segregate segregate VBP 917 922 human human JJ 923 934 chromosomes chromosome NNS 934 935 , , , 936 941 these these DT 942 949 results result NNS 950 958 indicate indicate VBP 959 962 the the DT 963 972 existence existence NN 973 975 of of IN 976 977 a a DT 978 990 non-syntenic non-syntenic JJ 991 1003 trans-active trans-active JJ 1004 1009 locus locus NN 1009 1010 , , , 1011 1013 or or CC 1014 1018 loci locus NNS 1018 1019 , , , 1020 1030 positively positively RB 1031 1042 controlling control VBG 1043 1046 the the DT 1047 1057 expression expression NN 1058 1060 of of IN 1061 1064 the the DT 1065 1070 human human JJ 1071 1074 CD5 cd5 NN 1075 1079 gene gene NN 1079 1080 . . .