0 9 Inducible inducible JJ 10 17 binding binding NN 18 20 to to TO 21 24 the the DT 25 30 c-fos c-fos NN 31 36 serum serum NN 37 45 response response NN 46 53 element element NN 54 60 during during IN 61 62 T t NN 63 67 cell cell NN 68 78 activation activation NN 79 81 is be VBZ 82 91 regulated regulate VBN 92 94 by by IN 95 96 a a DT 97 123 phosphotyrosine-containing phosphotyrosine-containing JJ 124 131 protein protein NN 131 132 . . . 134 137 The the DT 138 152 proto-oncogene proto-oncogene NN 153 158 c-fos c-fos NN 159 161 is be VBZ 162 164 an an DT 165 180 immediate-early immediate-early JJ 181 185 gene gene NN 185 186 , , , 187 190 and and CC 191 194 one one CD 195 197 of of IN 198 201 the the DT 202 207 first first JJ 208 213 genes gene NNS 214 225 transcribed transcribe VBN 226 231 after after IN 232 243 stimulation stimulation NN 244 246 of of IN 247 251 most most JJS 252 257 cells cell NNS 258 262 with with IN 263 264 a a DT 265 272 variety variety NN 273 275 of of IN 276 283 ligands ligand NNS 283 284 . . . 285 288 Fos Fos NNP 289 299 expression expression NN 300 303 may may MD 304 306 be be VB 307 308 a a DT 309 316 pivotal pivotal JJ 317 322 event event NN 323 325 in in IN 326 336 converting convert VBG 337 352 ligand-receptor ligand-receptor JJ 353 365 interactions interaction NNS 366 368 at at IN 369 372 the the DT 373 381 membrane membrane NN 382 386 into into IN 387 397 functional functional JJ 398 408 modulation modulation NN 409 411 of of IN 412 416 cell cell NN 417 426 phenotype phenotype NN 426 427 . . . 428 431 The the DT 432 437 serum serum NN 438 446 response response NN 447 454 element element NN 455 456 ( ( ( 456 459 SRE SRE NNP 459 460 ) ) ) 461 463 in in IN 464 467 the the DT 468 473 c-fos c-fos NN 474 484 regulatory regulatory JJ 485 491 region region NN 492 504 participates participate VBZ 505 507 in in IN 508 517 induction induction NN 518 520 of of IN 521 534 transcription transcription NN 535 537 by by IN 538 545 various various JJ 546 552 growth growth NN 553 560 factors factor NNS 561 564 and and CC 565 567 by by IN 568 575 phorbol phorbol NN 576 582 esters ester NNS 583 586 and and CC 587 597 subsequent subsequent JJ 598 608 squelching squelching NN 609 611 of of IN 612 625 transcription transcription NN 625 626 . . . 627 629 We we PRP 630 634 show show VBP 635 639 that that IN 640 642 an an DT 643 652 inducible inducible JJ 653 660 protein protein NN 661 668 complex complex NN 669 670 ( ( ( 670 674 Band Band NNP 675 676 A A NNP 676 677 ) ) ) 678 683 binds bind VBZ 684 686 to to TO 687 690 SRE sre NN 691 694 DNA dna NN 695 701 within within IN 702 704 10 10 CD 705 708 min min NN 709 714 after after IN 715 724 mitogenic mitogenic JJ 725 736 stimulation stimulation NN 737 739 of of IN 740 745 human human JJ 746 751 PBL-T pbl-t NN 751 752 , , , 753 756 and and CC 757 764 becomes become VBZ 765 778 nondetectable nondetectable JJ 779 781 by by IN 782 784 60 60 CD 785 789 min. min. NN 790 794 Band Band NNP 795 796 A A NNP 797 805 contains contain VBZ 806 809 the the DT 810 815 serum serum NN 816 824 response response NN 825 831 factor factor NN 832 836 plus plus CC 837 847 additional additional JJ 848 857 factor(s) factor(s) NN 857 858 . . . 859 860 A a DT 861 868 protein protein NN 869 873 that that WDT 874 876 is be VBZ 877 891 phosphorylated phosphorylate VBN 892 894 on on IN 895 896 a a DT 897 905 tyrosine tyrosine NN 906 913 residue residue NN 914 916 in in IN 917 924 resting rest VBG 925 930 PBL-T PBL-T NNP 931 941 suppresses suppress VBZ 942 949 binding binding NN 950 952 of of IN 953 954 a a DT 955 964 component component NN 965 967 of of IN 968 972 Band Band NNP 973 974 A A NNP 975 977 to to TO 978 981 the the DT 982 985 SRE SRE NNP 986 991 motif motif NN 991 992 . . . 993 997 Upon upon IN 998 1009 stimulation stimulation NN 1010 1012 of of IN 1013 1016 the the DT 1017 1022 cells cell NNS 1022 1023 , , , 1024 1028 this this DT 1029 1036 protein protein NN 1037 1039 no no RB 1040 1046 longer longer RB 1047 1055 prevents prevent VBZ 1056 1063 binding binding NN 1064 1066 of of IN 1067 1070 DNA DNA NNP 1071 1073 by by IN 1074 1078 Band Band NNP 1079 1080 A A NNP 1080 1081 , , , 1082 1085 and and CC 1086 1097 suppression suppression NN 1098 1100 of of IN 1101 1108 binding binding NN 1109 1111 is be VBZ 1112 1120 restored restore VBN 1121 1127 within within IN 1128 1130 30 30 CD 1131 1134 min min NN 1134 1135 . . . 1136 1139 The the DT 1140 1154 phosphorylated phosphorylate VBN 1155 1163 tyrosine tyrosine NN 1164 1171 residue residue NN 1172 1178 itself itself PRP 1179 1181 is be VBZ 1182 1191 important important JJ 1192 1195 for for IN 1196 1199 the the DT 1200 1215 protein-protein protein-protein JJ 1216 1227 interaction interaction NN 1227 1228 . . .