0	25	Transcription-independent	transcription-independent	JJ
26	34	turnover	turnover	NN
35	37	of	of	IN
38	39	I	i	NN
40	45	kappa	kappa	NN
46	47	B	B	NNP
48	53	alpha	alpha	NN
54	60	during	during	IN
61	69	monocyte	monocyte	NN
70	79	adherence	adherence	NN
79	80	:	:	:
81	93	implications	implication	NNS
94	97	for	for	IN
98	99	a	a	DT
100	113	translational	translational	JJ
114	123	component	component	NN
124	134	regulating	regulate	VBG
135	136	I	i	NN
137	142	kappa	kappa	NN
143	144	B	B	NNP
145	156	alpha/MAD-3	alpha/mad-3	NN
157	161	mRNA	mrna	NN
162	168	levels	level	NNS
168	169	.	.	.

171	173	We	we	PRP
174	184	identified	identify	VBD
185	186	I	i	NN
187	192	kappa	kappa	NN
193	194	B	B	NNP
195	206	alpha/MAD-3	alpha/mad-3	NN
207	209	as	as	IN
210	212	an	an	DT
213	228	immediate-early	immediate-early	JJ
229	233	gene	gene	NN
234	236	in	in	IN
237	242	human	human	JJ
243	252	monocytes	monocyte	NNS
253	257	that	that	WDT
258	260	is	be	VBZ
261	270	expressed	express	VBN
271	273	in	in	IN
274	282	response	response	NN
283	285	to	to	TO
286	287	a	a	DT
288	295	variety	variety	NN
296	298	of	of	IN
299	306	signals	signal	NNS
306	307	,	,	,
308	317	including	include	VBG
318	326	adhesion	adhesion	NN
326	327	,	,	,
328	346	lipopolysaccharide	lipopolysaccharide	NN
346	347	,	,	,
348	351	and	and	CC
352	359	phorbol	phorbol	NN
360	369	myristate	myristate	NN
370	377	acetate	acetate	NN
377	378	.	.	.

379	385	Within	within	IN
386	387	5	5	CD
388	391	min	min	NN
392	394	of	of	IN
395	403	monocyte	monocyte	NN
404	412	adhesion	adhesion	NN
412	413	,	,	,
414	417	the	the	DT
418	423	level	level	NN
424	426	of	of	IN
427	430	the	the	DT
431	432	I	i	NN
433	438	kappa	kappa	NN
439	440	B	B	NNP
441	446	alpha	alpha	NN
447	454	protein	protein	NN
455	457	is	be	VBZ
458	466	markedly	markedly	RB
467	477	diminished	diminish	VBN
478	481	but	but	CC
482	484	is	be	VBZ
485	492	rapidly	rapidly	RB
493	501	replaced	replace	VBN
502	504	in	in	IN
505	506	a	a	DT
507	530	cycloheximide-sensitive	cycloheximide-sensitive	JJ
531	537	manner	manner	NN
538	544	within	within	IN
545	547	20	20	CD
548	552	min.	min.	NN
553	565	Accompanying	accompany	VBG
566	569	the	the	DT
570	575	rapid	rapid	JJ
576	584	turnover	turnover	NN
585	587	of	of	IN
588	591	the	the	DT
592	593	I	i	NN
594	599	kappa	kappa	NN
600	601	B	B	NNP
602	607	alpha	alpha	NN
608	615	protein	protein	NN
616	618	is	be	VBZ
619	631	simultaneous	simultaneous	JJ
632	645	translocation	translocation	NN
646	648	of	of	IN
649	657	NF-kappa	NF-kappa	NNP
658	667	B-related	b-related	JJ
668	681	transcription	transcription	NN
682	689	factors	factor	NNS
690	692	to	to	TO
693	699	nuclei	nucleus	NNS
700	702	of	of	IN
703	710	adhered	adhered	JJ
711	720	monocytes	monocyte	NNS
720	721	.	.	.

722	725	The	the	DT
726	739	demonstration	demonstration	NN
740	744	that	that	IN
745	753	NF-kappa	NF-kappa	NNP
754	755	B	B	NNP
756	759	can	can	MD
760	768	regulate	regulate	VB
769	770	I	i	NN
771	776	kappa	kappa	NN
777	778	B	B	NNP
779	790	alpha/MAD-3	alpha/mad-3	NN
791	795	gene	gene	NN
796	809	transcription	transcription	NN
810	812	in	in	IN
813	818	other	other	JJ
819	823	cell	cell	NN
824	829	types	type	NNS
830	839	suggested	suggest	VBD
840	844	that	that	IN
845	848	the	the	DT
849	854	rapid	rapid	JJ
855	863	increase	increase	NN
864	866	in	in	IN
867	879	steady-state	steady-state	JJ
880	881	I	i	NN
882	887	kappa	kappa	NN
888	889	B	B	NNP
890	901	alpha/MAD-3	alpha/mad-3	NN
902	906	mRNA	mrna	NN
907	913	levels	level	NNS
914	916	we	we	PRP
917	925	observed	observe	VBD
926	932	within	within	IN
933	935	30	30	CD
936	939	min	min	NN
940	942	of	of	IN
943	951	monocyte	monocyte	NN
952	961	adherence	adherence	NN
962	967	would	would	MD
968	974	result	result	VB
975	979	from	from	IN
980	988	NF-kappa	NF-kappa	NNP
989	1000	B-dependent	b-dependent	JJ
1001	1016	transcriptional	transcriptional	JJ
1017	1028	stimulation	stimulation	NN
1029	1031	of	of	IN
1032	1035	the	the	DT
1036	1037	I	i	NN
1038	1043	kappa	kappa	NN
1044	1045	B	B	NNP
1046	1057	alpha/MAD-3	alpha/mad-3	NN
1058	1062	gene	gene	NN
1062	1063	.	.	.

1064	1071	Nuclear	nuclear	JJ
1072	1078	run-on	run-on	JJ
1079	1087	analyses	analysis	NNS
1088	1097	indicated	indicate	VBD
1098	1102	that	that	IN
1102	1103	,	,	,
1104	1111	instead	instead	RB
1111	1112	,	,	,
1113	1118	while	while	IN
1119	1126	several	several	JJ
1127	1142	immediate-early	immediate-early	JJ
1143	1151	cytokine	cytokine	NN
1152	1157	genes	gene	NNS
1157	1158	,	,	,
1159	1163	such	such	JJ
1164	1166	as	as	IN
1167	1170	the	the	DT
1171	1182	interleukin	interleukin	NN
1183	1184	1	1	CD
1185	1189	beta	beta	NN
1190	1191	(	(	(
1191	1195	IL-1	il-1	NN
1196	1200	beta	beta	NN
1200	1201	)	)	)
1202	1206	gene	gene	NN
1206	1207	,	,	,
1208	1212	were	be	VBD
1213	1230	transcriptionally	transcriptionally	RB
1231	1240	activated	activate	VBN
1241	1247	during	during	IN
1248	1256	monocyte	monocyte	NN
1257	1265	adhesion	adhesion	NN
1265	1266	,	,	,
1267	1270	the	the	DT
1271	1275	rate	rate	NN
1276	1278	of	of	IN
1279	1280	I	i	NN
1281	1286	kappa	kappa	NN
1287	1288	B	B	NNP
1289	1300	alpha/MAD-3	alpha/mad-3	NN
1301	1305	gene	gene	NN
1306	1319	transcription	transcription	NN
1320	1328	remained	remain	VBD
1329	1337	constant	constant	JJ
1337	1338	.	.	.

1339	1342	The	the	DT
1343	1362	adherence-dependent	adherence-dependent	JJ
1363	1371	increase	increase	NN
1372	1374	in	in	IN
1375	1376	I	i	NN
1377	1382	kappa	kappa	NN
1383	1384	B	B	NNP
1385	1396	alpha/MAD-3	alpha/mad-3	NN
1397	1401	mRNA	mrna	NN
1402	1408	levels	level	NNS
1409	1412	was	be	VBD
1413	1417	also	also	RB
1418	1421	not	not	RB
1422	1423	a	a	DT
1424	1435	consequence	consequence	NN
1436	1438	of	of	IN
1439	1443	mRNA	mrna	NN
1444	1457	stabilization	stabilization	NN
1458	1464	events	event	NNS
1464	1465	.	.	.

1466	1479	Interestingly	interestingly	RB
1479	1480	,	,	,
1481	1486	while	while	IN
1487	1496	increases	increase	NNS
1497	1499	in	in	IN
1500	1504	both	both	CC
1505	1509	IL-1	il-1	NN
1510	1514	beta	beta	NN
1515	1518	and	and	CC
1519	1520	I	i	NN
1521	1526	kappa	kappa	NN
1527	1528	B	B	NNP
1529	1540	alpha/MAD-3	alpha/mad-3	NN
1541	1545	mRNA	mrna	NN
1546	1552	levels	level	NNS
1553	1557	were	be	VBD
1558	1566	detected	detect	VBN
1567	1569	in	in	IN
1570	1576	nuclei	nucleus	NNS
1577	1579	of	of	IN
1580	1588	adherent	adherent	JJ
1589	1598	monocytes	monocyte	NNS
1598	1599	,	,	,
1600	1611	cytoplasmic	cytoplasmic	JJ
1612	1618	levels	level	NNS
1619	1621	of	of	IN
1622	1626	IL-1	il-1	NN
1627	1631	beta	beta	NN
1632	1636	mRNA	mrna	NN
1637	1646	increased	increase	VBD
1647	1653	during	during	IN
1654	1663	adherence	adherence	NN
1664	1671	whereas	whereas	IN
1672	1677	those	those	DT
1678	1680	of	of	IN
1681	1682	I	i	NN
1683	1688	kappa	kappa	NN
1689	1690	B	B	NNP
1691	1702	alpha/MAD-3	alpha/MAD-3	NNP
1703	1707	mRNA	mRNA	NNP
1708	1711	did	do	VBD
1712	1715	not	not	RB
1715	1716	.	.	.

1717	1722	Taken	take	VBN
1723	1731	together	together	RB
1731	1732	,	,	,
1733	1736	our	our	PRP$
1737	1741	data	datum	NNS
1742	1749	suggest	suggest	VBP
1750	1754	that	that	IN
1755	1758	two	two	CD
1759	1770	interactive	interactive	JJ
1771	1781	mechanisms	mechanism	NNS
1782	1790	regulate	regulate	VBP
1791	1800	monocytic	monocytic	JJ
1801	1802	I	i	NN
1803	1808	kappa	kappa	NN
1809	1810	B	B	NNP
1811	1822	alpha/MAD-3	alpha/mad-3	NN
1823	1827	mRNA	mrna	NN
1828	1834	levels	level	NNS
1834	1835	.	.	.

1836	1838	We	we	PRP
1839	1846	propose	propose	VBP
1847	1851	that	that	IN
1852	1860	adherent	adherent	JJ
1861	1870	monocytes	monocyte	NNS
1871	1879	regulate	regulate	VBP
1880	1887	nuclear	nuclear	JJ
1888	1898	processing	processing	NN
1899	1900	(	(	(
1900	1902	or	or	CC
1903	1908	decay	decay	NN
1908	1909	)	)	)
1910	1912	of	of	IN
1913	1914	I	i	NN
1915	1920	kappa	kappa	NN
1921	1922	B	B	NNP
1923	1934	alpha/MAD-3	alpha/MAD-3	NNP
1935	1939	mRNA	mRNA	NNP
1939	1940	,	,	,
1941	1948	thereby	thereby	RB
1949	1959	increasing	increase	VBG
1960	1964	mRNA	mrna	NN
1965	1971	levels	level	NNS
1972	1979	without	without	IN
1980	1991	stimulating	stimulate	VBG
1992	1993	I	i	NN
1994	1999	kappa	kappa	NN
2000	2001	B	B	NNP
2002	2013	alpha/MAD-3	alpha/mad-3	NN
2014	2018	gene	gene	NN
2019	2032	transcription	transcription	NN
2032	2033	.	.	.

2034	2042	Moreover	moreover	RB
2042	2043	,	,	,
2044	2049	since	since	IN
2050	2060	inhibition	inhibition	NN
2061	2063	of	of	IN
2064	2071	protein	protein	NN
2072	2081	synthesis	synthesis	NN
2082	2087	leads	lead	VBZ
2088	2090	to	to	TO
2091	2103	accumulation	accumulation	NN
2104	2106	of	of	IN
2107	2108	I	i	NN
2109	2114	kappa	kappa	NN
2115	2116	B	B	NNP
2117	2128	alpha/MAD-3	alpha/mad-3	NN
2129	2133	mRNA	mRNA	NNP
2134	2141	without	without	IN
2142	2153	stimulating	stimulate	VBG
2154	2155	I	i	NN
2156	2161	kappa	kappa	NN
2162	2163	B	B	NNP
2164	2175	alpha/MAD-3	alpha/mad-3	NN
2176	2180	gene	gene	NN
2181	2194	transcription	transcription	NN
2194	2195	,	,	,
2196	2198	we	we	PRP
2199	2206	suggest	suggest	VBP
2207	2211	that	that	IN
2212	2215	low	low	JJ
2216	2227	cytoplasmic	cytoplasmic	JJ
2228	2234	levels	level	NNS
2235	2237	of	of	IN
2238	2239	I	i	NN
2240	2245	kappa	kappa	NN
2246	2247	B	B	NNP
2248	2259	alpha/MAD-3	alpha/MAD-3	NNP
2260	2264	mRNA	mRNA	NNP
2265	2268	are	be	VBP
2269	2279	maintained	maintain	VBN
2280	2282	by	by	IN
2283	2284	a	a	DT
2285	2306	translation-dependent	translation-dependent	JJ
2307	2318	degradation	degradation	NN
2319	2328	mechanism	mechanism	NN
2328	2329	.	.	.