0	5	E2F-1	E2F-1	NNP
6	9	and	and	CC
10	11	a	a	DT
12	23	cyclin-like	cyclin-like	JJ
24	27	DNA	dna	NN
28	34	repair	repair	NN
35	41	enzyme	enzyme	NN
41	42	,	,	,
43	53	uracil-DNA	uracil-dna	NN
54	65	glycosylase	glycosylase	NN
65	66	,	,	,
67	74	provide	provide	VBP
75	83	evidence	evidence	NN
84	87	for	for	IN
88	90	an	an	DT
91	105	autoregulatory	autoregulatory	JJ
106	115	mechanism	mechanism	NN
116	119	for	for	IN
120	133	transcription	transcription	NN
133	134	.	.	.

136	139	The	the	DT
140	144	cell	cell	NN
145	160	cycle-dependent	cycle-dependent	JJ
161	174	transcription	transcription	NN
175	181	factor	factor	NN
181	182	,	,	,
183	188	E2F-1	E2F-1	NNP
188	189	,	,	,
190	199	regulates	regulate	VBZ
200	203	the	the	DT
204	215	cyclin-like	cyclin-like	JJ
216	223	species	specie	NNS
224	226	of	of	IN
227	230	the	the	DT
231	234	DNA	DNA	NNP
235	241	repair	repair	NN
242	248	enzyme	enzyme	NN
249	259	uracil-DNA	uracil-dna	NN
260	271	glycosylase	glycosylase	NN
272	273	(	(	(
273	276	UDG	UDG	NNP
276	277	)	)	)
278	282	gene	gene	NN
283	285	in	in	IN
286	291	human	human	JJ
292	304	osteosarcoma	osteosarcoma	NN
305	306	(	(	(
306	312	Saos-2	saos-2	NN
312	313	)	)	)
314	319	cells	cell	NNS
319	320	.	.	.

321	323	We	we	PRP
324	335	demonstrate	demonstrate	VBP
335	336	,	,	,
337	344	through	through	IN
345	348	the	the	DT
349	357	deletion	deletion	NN
358	360	of	of	IN
361	364	the	the	DT
365	370	human	human	JJ
371	374	UDG	UDG	NNP
375	383	promoter	promoter	NN
384	393	sequences	sequence	NNS
393	394	,	,	,
395	399	that	that	IN
400	410	expression	expression	NN
411	413	of	of	IN
414	419	E2F-1	E2F-1	NNP
420	429	activates	activate	VBZ
430	433	the	the	DT
434	437	UDG	UDG	NNP
438	446	promoter	promoter	NN
447	454	through	through	IN
455	462	several	several	JJ
463	466	E2F	e2f	NN
467	472	sites	site	NNS
472	473	.	.	.

474	477	The	the	DT
478	483	major	major	JJ
484	492	putative	putative	JJ
493	503	downstream	downstream	JJ
504	508	site	site	NN
509	512	for	for	IN
513	516	E2F	E2F	NNP
516	517	,	,	,
518	525	located	located	JJ
526	528	in	in	IN
529	532	the	the	DT
533	538	first	first	JJ
539	543	exon	exon	NN
543	544	,	,	,
545	551	serves	serve	VBZ
552	554	as	as	IN
555	556	a	a	DT
557	563	target	target	NN
564	567	for	for	IN
568	577	E2F-1/DP1	e2f-1/dp1	NN
578	585	complex	complex	NN
586	593	binding	binding	NN
594	596	in	in	FW
597	602	vitro	vitro	FW
602	603	.	.	.

604	606	We	we	PRP
607	611	also	also	RB
612	619	provide	provide	VBP
620	628	evidence	evidence	NN
629	632	for	for	IN
633	636	the	the	DT
637	647	functional	functional	JJ
648	660	relationship	relationship	NN
661	668	between	between	IN
669	672	the	the	DT
673	684	cyclin-like	cyclin-like	JJ
685	688	UDG	UDG	NNP
689	693	gene	gene	NN
694	701	product	product	NN
702	705	and	and	CC
706	710	E2F.	E2F.	NNP
711	715	High	high	JJ
716	722	levels	level	NNS
723	725	of	of	IN
726	729	UDG	udg	NN
730	740	expression	expression	NN
741	743	in	in	IN
744	745	a	a	DT
746	755	transient	transient	JJ
756	768	transfection	transfection	NN
769	774	assay	assay	NN
775	781	result	result	VBP
782	784	in	in	IN
785	788	the	the	DT
789	804	down-regulation	down-regulation	NN
805	807	of	of	IN
808	823	transcriptional	transcriptional	JJ
824	832	activity	activity	NN
833	840	through	through	IN
841	849	elements	element	NNS
850	858	specific	specific	JJ
859	862	for	for	IN
863	875	E2F-mediated	e2f-mediated	JJ
876	889	transcription	transcription	NN
889	890	.	.	.

891	905	Overexpression	Overexpression	NNP
906	908	of	of	IN
909	912	UDG	UDG	NNP
913	915	in	in	IN
916	920	Saos	Saos	NNP
921	922	2	2	CD
923	928	cells	cell	NNS
929	932	was	be	VBD
933	941	observed	observe	VBN
942	944	to	to	TO
945	950	delay	delay	VB
951	957	growth	growth	NN
958	962	late	late	RB
963	965	in	in	IN
966	968	G1	g1	NN
969	974	phase	phase	NN
975	978	and	and	CC
979	990	transiently	transiently	RB
991	997	arrest	arrest	VB
998	1003	these	these	DT
1004	1009	cells	cell	NNS
1010	1014	from	from	IN
1015	1026	progressing	progress	VBG
1027	1031	into	into	IN
1032	1035	the	the	DT
1036	1037	S	S	NNP
1038	1043	phase	phase	NN
1043	1044	.	.	.

1045	1049	This	this	DT
1050	1062	hypothetical	hypothetical	JJ
1063	1068	model	model	NN
1069	1079	integrates	integrate	VBZ
1080	1083	one	one	CD
1084	1093	mechanism	mechanism	NN
1094	1096	of	of	IN
1097	1100	DNA	DNA	NNP
1101	1107	repair	repair	NN
1108	1112	with	with	IN
1113	1116	the	the	DT
1117	1121	cell	cell	NN
1122	1127	cycle	cycle	NN
1128	1135	control	control	NN
1136	1138	of	of	IN
1139	1143	gene	gene	NN
1144	1157	transcription	transcription	NN
1157	1158	,	,	,
1159	1165	likely	likely	RB
1166	1173	through	through	IN
1174	1177	E2F	E2F	NNP
1177	1178	.	.	.

1179	1183	This	this	DT
1184	1194	implicates	implicate	VBZ
1195	1198	E2F	e2f	NN
1199	1201	as	as	IN
1202	1203	a	a	DT
1204	1219	multifunctional	multifunctional	JJ
1220	1226	target	target	NN
1227	1230	for	for	IN
1231	1239	proteins	protein	NNS
1240	1243	and	and	CC
1244	1251	enzymes	enzyme	NNS
1251	1252	,	,	,
1253	1261	possibly	possibly	RB
1261	1262	,	,	,
1263	1273	responsive	responsive	JJ
1274	1276	to	to	TO
1277	1280	DNA	dna	NN
1281	1287	damage	damage	NN
1288	1295	through	through	IN
1296	1299	the	the	DT
1300	1308	negative	negative	JJ
1309	1315	effect	effect	NN
1316	1318	of	of	IN
1319	1322	UDG	UDG	NNP
1323	1325	on	on	IN
1326	1338	E2F-mediated	e2f-mediated	JJ
1339	1354	transcriptional	transcriptional	JJ
1355	1363	activity	activity	NN
1363	1364	.	.	.