0 7 Danazol Danazol NNP 8 17 decreases decrease VBZ 18 31 transcription transcription NN 32 34 of of IN 35 43 estrogen estrogen NN 44 52 receptor receptor NN 53 57 gene gene NN 58 60 in in IN 61 66 human human JJ 67 76 monocytes monocyte NNS 76 77 . . . 79 80 1 1 LS 80 81 . . . 82 96 Administration Administration NNP 97 99 of of IN 100 107 danazol danazol NN 108 111 for for IN 112 116 over over IN 117 120 one one CD 121 126 month month NN 127 134 reduced reduce VBD 135 138 the the DT 139 145 levels level NNS 146 148 of of IN 149 157 estrogen estrogen NN 158 166 receptor receptor NN 167 168 ( ( ( 168 170 ER ER NNP 170 171 ) ) ) 172 175 and and CC 176 179 its its PRP$ 180 184 mRNA mrna NN 185 187 to to TO 188 201 approximately approximately RB 202 204 50 50 CD 205 208 and and CC 209 211 20 20 CD 211 212 % % NN 212 213 , , , 214 226 respectively respectively RB 227 229 in in IN 230 239 monocytes monocyte NNS 239 240 . . . 241 242 2 2 LS 242 243 . . . 244 251 Danazol Danazol NNP 252 255 did do VBD 256 259 not not RB 260 265 alter alter VB 266 269 the the DT 270 281 degradation degradation NN 282 286 rate rate NN 287 289 of of IN 290 292 ER ER NNP 293 297 mRNA mRNA NNP 298 300 in in IN 301 310 monocytes monocyte NNS 310 311 . . . 312 313 3 3 LS 313 314 . . . 315 322 Danazol Danazol NNP 323 332 decreased decrease VBD 333 336 the the DT 337 350 transcription transcription NN 351 355 rate rate NN 356 358 of of IN 359 361 ER ER NNP 362 366 gene gene NN 367 369 to to TO 370 383 approximately approximately RB 384 386 50 50 CD 386 387 % % NN 388 390 in in IN 391 400 monocytes monocyte NNS 401 403 in in IN 404 405 a a DT 406 412 run-on run-on JJ 413 418 assay assay NN 418 419 . . . 420 421 4 4 LS 421 422 . . . 423 430 Danazol Danazol NNP 431 434 may may MD 435 442 release release VB 443 451 estrogen estrogen NN 452 464 predominance predominance NN 465 468 via via IN 469 472 the the DT 473 482 reduction reduction NN 483 485 of of IN 486 499 transcription transcription NN 500 503 for for IN 504 506 ER ER NNP 507 511 gene gene NN 511 512 , , , 513 518 which which WDT 519 524 leads lead VBZ 525 527 to to TO 528 531 the the DT 532 541 reduction reduction NN 542 544 of of IN 545 547 ER ER NNP 548 552 mRNA mRNA NNP 553 556 and and CC 557 559 ER ER NNP 560 571 expressions expression NNS 572 574 in in IN 575 584 monocytes monocyte NNS 584 585 . . .