0 13 Cross-linking cross-linking NN 14 16 of of IN 17 21 CD30 CD30 NNP 22 29 induces induce VBZ 30 33 HIV HIV NNP 34 44 expression expression NN 45 47 in in IN 48 59 chronically chronically RB 60 68 infected infected JJ 69 70 T t NN 71 76 cells cell NNS 76 77 . . . 79 83 CD30 CD30 NNP 83 84 , , , 85 86 a a DT 87 93 member member NN 94 96 of of IN 97 100 the the DT 101 106 tumor tumor NN 107 115 necrosis necrosis NN 116 122 factor factor NN 123 124 ( ( ( 124 127 TNF TNF NNP 127 128 ) ) ) 129 137 receptor receptor NN 138 144 family family NN 144 145 , , , 146 148 is be VBZ 149 158 expressed express VBN 159 173 constitutively constitutively RB 174 176 on on IN 177 180 the the DT 181 188 surface surface NN 189 191 of of IN 192 195 the the DT 196 201 human human JJ 202 203 T t NN 204 208 cell cell NN 209 213 line line NN 214 219 ACH-2 ach-2 NN 219 220 , , , 221 226 which which WDT 227 229 is be VBZ 230 241 chronically chronically RB 242 250 infected infect VBN 251 255 with with IN 256 261 human human JJ 262 278 immunodeficiency immunodeficiency NN 279 284 virus virus NN 285 291 type-1 type-1 NN 292 293 ( ( ( 293 299 HIV)-1 HIV)-1 NNP 299 300 . . . 301 303 We we PRP 304 315 demonstrate demonstrate VBP 316 320 that that IN 321 334 cross-linking cross-linking JJ 335 339 CD30 cd30 NN 340 344 with with IN 345 347 an an DT 348 366 anti-CD30-specific anti-cd30-specific JJ 367 377 monoclonal monoclonal JJ 378 386 antibody antibody NN 386 387 , , , 388 393 which which WDT 394 400 mimics mimic VBZ 401 404 the the DT 405 414 described describe VBN 415 425 biological biological JJ 426 436 activities activity NNS 437 439 of of IN 440 443 the the DT 444 448 CD30 cd30 NN 449 455 ligand ligand NN 456 457 ( ( ( 457 462 CD30L CD30L NNP 462 463 ) ) ) 463 464 , , , 465 472 results result VBZ 473 475 in in IN 476 479 HIV HIV NNP 480 490 expression expression NN 490 491 . . . 492 496 CD30 CD30 NNP 497 510 cross-linking cross-linking NN 511 515 does do VBZ 516 519 not not RB 520 525 alter alter VB 526 539 proliferation proliferation NN 540 542 of of IN 543 548 ACH-2 ach-2 NN 549 554 cells cell NNS 555 558 and and CC 559 562 the the DT 563 572 induction induction NN 573 575 of of IN 576 579 HIV HIV NNP 580 590 expression expression NN 591 593 is be VBZ 594 597 not not RB 598 606 mediated mediate VBN 607 609 by by IN 610 620 endogenous endogenous JJ 621 624 TNF TNF NNP 625 635 alpha/beta alpha/beta NN 635 636 . . . 637 648 Furthermore furthermore RB 648 649 , , , 650 663 cross-linking cross-linking NN 664 666 of of IN 667 671 CD30 CD30 NNP 672 677 leads lead VBZ 678 680 to to TO 681 689 NF-kappa NF-kappa NNP 690 691 B B NNP 692 702 activation activation NN 703 706 and and CC 707 715 enhanced enhance VBN 716 719 HIV HIV NNP 720 733 transcription transcription NN 733 734 . . . 735 739 Thus thus RB 739 740 , , , 741 751 CD30-CD30L cd30-cd30l JJ 752 764 interactions interaction NNS 765 772 mediate mediate VBP 773 776 the the DT 777 786 induction induction NN 787 789 of of IN 790 793 HIV HIV NNP 794 804 expression expression NN 805 807 by by IN 808 809 a a DT 810 815 kappa kappa NN 816 827 B-dependent b-dependent JJ 828 835 pathway pathway NN 836 840 that that WDT 841 843 is be VBZ 844 855 independent independent JJ 856 858 of of IN 859 862 TNF TNF NNP 862 863 . . . 864 868 This this DT 869 878 mechanism mechanism NN 879 882 may may MD 883 885 be be VB 886 895 important important JJ 896 898 in in IN 899 902 the the DT 903 913 activation activation NN 914 916 of of IN 917 920 HIV HIV NNP 921 931 expression expression NN 932 936 from from IN 937 945 latently latently RB 946 954 infected infected JJ 955 959 CD4+ cd4+ JJ 960 961 T t NN 962 967 cells cell NNS 967 968 , , , 969 979 especially especially RB 980 982 in in IN 983 991 lymphoid lymphoid JJ 992 998 organs organ NNS 999 1004 where where WRB 1005 1009 cell cell NN 1010 1012 to to TO 1013 1017 cell cell NN 1018 1025 contact contact NN 1026 1028 is be VBZ 1029 1038 conducive conducive JJ 1039 1041 to to TO 1042 1057 receptor-ligand receptor-ligand JJ 1058 1070 interactions interaction NNS 1070 1071 . . .