0 3 The the DT 4 10 normal normal JJ 11 15 cell cell NN 16 21 cycle cycle NN 22 32 activation activation NN 33 40 program program NN 41 43 is be VBZ 44 53 exploited exploit VBN 54 60 during during IN 61 64 the the DT 65 74 infection infection NN 75 77 of of IN 78 87 quiescent quiescent JJ 88 89 B B NNP 90 101 lymphocytes lymphocyte NNS 102 104 by by IN 105 117 Epstein-Barr epstein-barr JJ 118 123 virus virus NN 123 124 . . . 126 127 B B NNP 128 139 lymphocytes lymphocyte NNS 140 142 in in IN 143 146 the the DT 147 157 peripheral peripheral JJ 158 169 circulation circulation NN 170 173 are be VBP 174 184 maintained maintain VBN 185 187 in in IN 188 189 a a DT 190 207 non-proliferative non-proliferative JJ 208 213 state state NN 213 214 . . . 215 222 Antigen antigen NN 223 234 recognition recognition NN 235 245 stimulates stimulate VBZ 246 253 limited limited JJ 254 267 proliferation proliferation NN 267 268 , , , 269 276 whereas whereas IN 277 286 infection infection NN 287 291 with with IN 292 304 Epstein-Barr epstein-barr JJ 305 310 virus virus NN 311 312 ( ( ( 312 315 EBV EBV NNP 315 316 ) ) ) 317 324 results result VBZ 325 327 in in IN 328 337 continual continual JJ 338 351 proliferation proliferation NN 352 355 and and CC 356 359 the the DT 360 369 outgrowth outgrowth NN 370 372 of of IN 373 381 immortal immortal JJ 382 386 cell cell NN 387 392 lines line NNS 392 393 . . . 394 401 Because because IN 402 404 it it PRP 405 407 is be VBZ 408 411 not not RB 412 417 clear clear JJ 418 420 at at IN 421 426 which which WDT 427 432 point point NN 433 435 in in IN 436 440 cell cell NN 441 446 cycle cycle NN 447 450 the the DT 451 461 peripheral peripheral JJ 462 463 B B NNP 464 475 lymphocytes lymphocyte NNS 476 479 are be VBP 480 488 arrested arrest VBN 488 489 , , , 490 492 we we PRP 493 506 characterized characterize VBD 507 510 the the DT 511 521 expression expression NN 522 524 of of IN 525 532 several several JJ 533 537 cell cell NN 538 554 cycle-associated cycle-associated JJ 555 560 genes gene NNS 561 563 in in IN 564 573 quiescent quiescent JJ 574 577 and and CC 578 588 stimulated stimulate VBN 589 594 cells cell NNS 594 595 . . . 596 598 We we PRP 599 603 show show VBP 604 608 that that IN 609 612 the the DT 613 623 expression expression NN 624 626 of of IN 627 631 four four CD 632 636 cell cell NN 637 642 genes gene NNS 642 643 , , , 644 649 cdc-2 cdc-2 NN 649 650 , , , 651 657 cyclin cyclin NN 658 659 E e NN 659 660 , , , 661 665 CD23 CD23 NNP 665 666 , , , 667 670 and and CC 671 677 cyclin cyclin NN 678 680 D2 d2 NN 680 681 , , , 682 685 are be VBP 686 698 up-regulated up-regulate VBN 699 712 approximately approximately RB 713 721 100-fold 100-fold RB 722 724 as as IN 725 726 a a DT 727 733 result result NN 734 736 of of IN 737 749 EBV-mediated ebv-mediated JJ 750 765 immortalization immortalization NN 765 766 . . . 767 774 Because because IN 775 780 these these DT 781 786 genes gene NNS 787 791 play play VBP 792 793 a a DT 794 802 positive positive JJ 803 807 role role NN 808 810 in in IN 811 815 cell cell NN 816 829 proliferation proliferation NN 829 830 , , , 831 833 we we PRP 834 841 suggest suggest VBP 842 846 that that IN 847 851 this this DT 852 862 regulatory regulatory JJ 863 869 switch switch NN 870 881 contributes contribute VBZ 882 884 to to TO 885 896 controlling control VBG 897 902 entry entry NN 903 907 into into IN 908 911 the the DT 912 916 cell cell NN 917 922 cycle cycle NN 922 923 . . . 924 933 Transient transient JJ 934 945 stimulation stimulation NN 946 948 of of IN 949 958 quiescent quiescent JJ 959 960 B B NNP 961 972 lymphocytes lymphocyte NNS 973 977 with with IN 978 984 either either CC 985 986 a a DT 987 995 cocktail cocktail NN 996 998 of of IN 999 1008 anti-CD40 anti-cd40 NN 1008 1009 , , , 1010 1018 anti-IgM anti-IgM NNP 1018 1019 , , , 1020 1023 and and CC 1024 1027 IL4 il4 NN 1027 1028 , , , 1029 1031 or or CC 1032 1035 EBV EBV NNP 1036 1043 results result VBZ 1044 1046 in in IN 1047 1050 the the DT 1051 1056 rapid rapid JJ 1057 1067 expression expression NN 1068 1070 of of IN 1071 1074 the the DT 1075 1079 same same JJ 1080 1084 four four CD 1085 1090 genes gene NNS 1090 1091 , , , 1092 1102 suggesting suggest VBG 1103 1107 that that IN 1107 1108 , , , 1109 1114 after after IN 1115 1124 infection infection NN 1124 1125 , , , 1126 1129 EBV EBV NNP 1130 1138 exploits exploit VBZ 1139 1142 the the DT 1143 1149 normal normal JJ 1150 1157 program program NN 1158 1160 of of IN 1161 1173 B-lymphocyte B-lymphocyte NNP 1174 1178 cell cell NN 1179 1184 cycle cycle NN 1185 1195 activation activation NN 1195 1196 . . .