0 12 Constitutive constitutive JJ 13 21 NF-kappa NF-kappa NNP 22 23 B B NNP 24 34 activation activation NN 34 35 , , , 36 44 enhanced enhance VBN 45 59 granulopoiesis granulopoiesis NN 59 60 , , , 61 64 and and CC 65 73 neonatal neonatal JJ 74 83 lethality lethality NN 84 86 in in IN 87 88 I i NN 89 94 kappa kappa NN 95 96 B B NNP 97 112 alpha-deficient alpha-deficient JJ 113 117 mice mouse NNS 117 118 . . . 120 133 Transcription Transcription NNP 134 141 factors factor NNS 142 151 belonging belong VBG 152 154 to to TO 155 158 the the DT 159 167 NF-kappa NF-kappa NNP 168 169 B B NNP 170 176 family family NN 177 180 are be VBP 181 191 controlled control VBN 192 194 by by IN 195 205 inhibitory inhibitory JJ 206 207 I i NN 208 213 kappa kappa NN 214 215 B B NNP 216 224 proteins protein NNS 224 225 , , , 226 232 mainly mainly RB 233 234 I i NN 235 240 kappa kappa NN 241 242 B B NNP 243 248 alpha alpha NN 249 252 and and CC 253 254 I i NN 255 260 kappa kappa NN 261 262 B B NNP 263 267 beta beta NN 267 268 . . . 269 279 Apparently apparently RB 280 286 normal normal JJ 287 289 at at IN 290 295 birth birth NN 295 296 , , , 297 298 I i NN 299 304 kappa kappa NN 305 306 B B NNP 307 315 alpha-/- alpha-/- JJ 316 320 mice mouse NNS 321 328 exhibit exhibit VBP 329 335 severe severe JJ 336 343 runting runting NN 343 344 , , , 345 349 skin skin NN 350 357 defects defect NNS 357 358 , , , 359 362 and and CC 363 372 extensive extensive JJ 373 387 granulopoiesis granulopoiesis NN 388 399 postnatally postnatally RB 399 400 , , , 401 410 typically typically RB 411 416 dying die VBG 417 419 by by IN 420 421 8 8 CD 422 426 days day NNS 426 427 . . . 428 441 Hematopoietic hematopoietic JJ 442 449 tissues tissue NNS 450 454 from from IN 455 460 these these DT 461 465 mice mouse NNS 466 473 display display VBP 474 482 elevated elevated JJ 483 489 levels level NNS 490 492 of of IN 493 497 both both CC 498 505 nuclear nuclear JJ 506 514 NF-kappa NF-kappa NNP 515 516 B B NNP 517 520 and and CC 521 526 mRNAs mrna NNS 527 529 of of IN 530 534 some some DT 534 535 , , , 536 539 but but CC 540 543 not not RB 544 547 all all DT 547 548 , , , 549 554 genes gene NNS 555 562 thought think VBN 563 565 to to TO 566 568 be be VB 569 578 regulated regulate VBN 579 581 by by IN 582 590 NF-kappa NF-kappa NNP 591 593 B. B. NNP 594 602 NF-kappa NF-kappa NNP 603 604 B B NNP 605 614 elevation elevation NN 615 622 results result VBZ 623 625 in in IN 626 631 these these DT 632 642 phenotypic phenotypic JJ 643 656 abnormalities abnormality NNS 657 664 because because IN 665 669 mice mouse NNS 670 677 lacking lack VBG 678 682 both both CC 683 684 I i NN 685 690 kappa kappa NN 691 692 B B NNP 693 698 alpha alpha NN 699 702 and and CC 703 706 the the DT 707 710 p50 p50 NN 711 718 subunit subunit NN 719 721 of of IN 722 730 NF-kappa NF-kappa NNP 731 732 B B NNP 733 737 show show VBP 738 739 a a DT 740 752 dramatically dramatically RB 753 760 delayed delay VBN 761 766 onset onset NN 767 769 of of IN 770 783 abnormalities abnormality NNS 783 784 . . . 785 787 In in IN 788 796 contrast contrast NN 797 799 to to TO 800 813 hematopoietic hematopoietic JJ 814 819 cells cell NNS 819 820 , , , 821 822 I i NN 823 828 kappa kappa NN 829 830 B B NNP 831 839 alpha-/- alpha-/- JJ 840 849 embryonic embryonic JJ 850 861 fibroblasts fibroblast NNS 862 866 show show VBP 867 874 minimal minimal JJ 875 887 constitutive constitutive JJ 888 896 NF-kappa NF-kappa NNP 897 898 B B NNP 898 899 , , , 900 902 as as RB 903 907 well well RB 908 910 as as IN 911 917 normal normal JJ 918 934 signal-dependent signal-dependent JJ 935 943 NF-kappa NF-kappa NNP 944 945 B B NNP 946 956 activation activation NN 957 961 that that WDT 962 964 is be VBZ 965 976 concomitant concomitant JJ 977 981 with with IN 982 983 I i NN 984 989 kappa kappa NN 990 991 B B NNP 992 996 beta beta NN 997 1008 degradation degradation NN 1008 1009 . . . 1010 1013 Our our PRP$ 1014 1021 results result NNS 1022 1030 indicate indicate VBP 1031 1035 that that IN 1036 1037 I i NN 1038 1043 kappa kappa NN 1044 1045 b b NN 1046 1050 beta beta NN 1050 1051 , , , 1052 1055 but but CC 1056 1059 not not RB 1060 1061 I i NN 1062 1067 kappa kappa NN 1068 1069 B B NNP 1070 1075 alpha alpha NN 1075 1076 , , , 1077 1079 is be VBZ 1080 1088 required require VBN 1089 1092 for for IN 1093 1096 the the DT 1097 1113 signal-dependent signal-dependent JJ 1114 1124 activation activation NN 1125 1127 of of IN 1128 1136 NF-kappa NF-kappa NNP 1137 1138 B B NNP 1139 1141 in in IN 1142 1153 fibroblasts fibroblast NNS 1153 1154 . . . 1155 1162 However however RB 1162 1163 , , , 1164 1165 I i NN 1166 1171 kappa kappa NN 1172 1173 B B NNP 1174 1179 alpha alpha NN 1180 1182 is be VBZ 1183 1191 required require VBN 1192 1195 for for IN 1196 1199 the the DT 1200 1213 postinduction postinduction NN 1214 1224 repression repression NN 1225 1227 of of IN 1228 1236 NF-kappa NF-kappa NNP 1237 1238 B B NNP 1239 1241 in in IN 1242 1253 fibroblasts fibroblast NNS 1253 1254 . . . 1255 1260 These these DT 1261 1268 results result NNS 1269 1275 define define VBP 1276 1284 distinct distinct JJ 1285 1290 roles role NNS 1291 1294 for for IN 1295 1298 the the DT 1299 1302 two two CD 1303 1308 forms form NNS 1309 1311 of of IN 1312 1313 I i NN 1314 1319 kappa kappa NN 1320 1321 B B NNP 1322 1325 and and CC 1326 1337 demonstrate demonstrate VBP 1338 1341 the the DT 1342 1351 necessity necessity NN 1352 1355 for for IN 1356 1365 stringent stringent JJ 1366 1373 control control NN 1374 1376 of of IN 1377 1385 NF-kappa NF-kappa NNP 1386 1387 B B NNP 1387 1388 . . .