0	10	Regulation	Regulation	NNP
11	13	of	of	IN
14	17	IkB	IkB	NNP
18	23	alpha	alpha	NN
24	39	phosphorylation	phosphorylation	NN
40	42	by	by	IN
43	47	PKC-	PKC-	NNP
48	51	and	and	CC
52	68	Ca(2+)-dependent	ca(2+)-dependent	JJ
69	75	signal	signal	NN
76	88	transduction	transduction	NN
89	97	pathways	pathway	NNS
97	98	.	.	.

100	103	The	the	DT
104	120	Ca(2+)-dependent	ca(2+)-dependent	JJ
121	132	phosphatase	phosphatase	NN
133	144	calcineurin	calcineurin	NN
144	145	,	,	,
146	147	a	a	DT
148	154	target	target	NN
155	157	of	of	IN
158	163	FK506	FK506	NNP
164	167	and	and	CC
168	171	CsA	CsA	NNP
171	172	,	,	,
173	183	synergizes	synergize	VBZ
184	188	with	with	IN
189	200	PKC-induced	pkc-induced	JJ
201	211	activation	activation	NN
212	214	of	of	IN
215	222	nuclear	nuclear	JJ
223	229	factor	factor	NN
230	231	(	(	(
231	240	NF)-kappa	NF)-kappa	NNP
241	242	B	B	NNP
243	245	in	in	IN
246	247	T	t	NN
248	252	cell	cell	NN
253	258	lines	line	NNS
258	259	.	.	.

260	262	We	we	PRP
263	267	have	have	VBP
268	280	investigated	investigate	VBN
281	288	whether	whether	IN
289	293	this	this	DT
294	301	synergy	synergy	NN
302	304	is	be	VBZ
305	312	present	present	JJ
313	315	in	in	IN
316	321	other	other	JJ
322	326	cell	cell	NN
327	332	types	type	NNS
333	336	and	and	CC
337	340	the	the	DT
341	353	mechanism(s)	mechanism(s)	NN
354	356	by	by	IN
357	362	which	which	WDT
363	368	these	these	DT
369	372	two	two	CD
373	381	pathways	pathway	NNS
382	386	lead	lead	VBP
387	389	to	to	TO
390	398	NF-kappa	NF-kappa	NNP
399	400	B	B	NNP
401	411	activation	activation	NN
411	412	.	.	.

413	418	While	while	IN
419	423	this	this	DT
424	431	synergy	synergy	NN
432	434	is	be	VBZ
435	442	present	present	JJ
443	445	in	in	IN
446	451	other	other	JJ
452	456	cell	cell	NN
457	462	types	type	NNS
462	463	,	,	,
464	466	in	in	IN
467	470	the	the	DT
471	480	monocytic	monocytic	JJ
481	485	cell	cell	NN
486	490	line	line	NN
491	495	U937	u937	NN
496	507	calcineurin	calcineurin	NN
508	510	is	be	VBZ
511	515	also	also	RB
516	526	sufficient	sufficient	JJ
527	529	to	to	TO
530	538	activate	activate	VB
539	547	NF-kappa	NF-kappa	NNP
548	550	B.	B.	NNP
551	557	Having	have	VBG
558	568	previously	previously	RB
569	574	shown	show	VBN
575	579	that	that	IN
580	587	Ca(2+)-	Ca(2+)-	NNP
588	591	and	and	CC
592	605	PKC-dependent	pkc-dependent	JJ
606	614	pathways	pathway	NNS
615	624	synergize	synergize	VBP
625	627	by	by	IN
628	640	accelerating	accelerate	VBG
641	644	the	the	DT
645	656	degradation	degradation	NN
657	659	of	of	IN
660	663	IkB	IkB	NNP
664	669	alpha	alpha	NN
669	670	,	,	,
671	673	we	we	PRP
674	681	focused	focus	VBD
682	684	on	on	IN
685	688	the	the	DT
689	699	regulation	regulation	NN
700	702	of	of	IN
703	706	IkB	IkB	NNP
707	712	alpha	alpha	NN
713	728	phosphorylation	phosphorylation	NN
728	729	.	.	.

730	735	While	while	IN
736	749	PKC-dependent	pkc-dependent	JJ
750	758	pathways	pathway	NNS
759	771	sequentially	sequentially	RB
772	778	result	result	VBP
779	781	in	in	IN
782	785	the	the	DT
786	801	phosphorylation	phosphorylation	NN
802	805	and	and	CC
806	808	in	in	IN
809	811	an	an	DT
812	822	incomplete	incomplete	JJ
823	834	degradation	degradation	NN
835	837	of	of	IN
838	841	IkB	IkB	NNP
842	847	alpha	alpha	NN
848	850	in	in	IN
851	852	T	t	NN
853	857	cell	cell	NN
858	863	lines	line	NNS
863	864	,	,	,
865	878	co-activation	co-activation	NN
879	881	of	of	IN
882	898	Ca(2+)-dependent	ca(2+)-dependent	JJ
899	907	pathways	pathway	NNS
908	919	accelerates	accelerate	VBZ
920	923	the	the	DT
924	928	rate	rate	NN
929	931	of	of	IN
932	935	IkB	IkB	NNP
936	941	alpha	alpha	NN
942	957	phosphorylation	phosphorylation	NN
958	961	and	and	CC
962	969	results	result	VBZ
970	972	in	in	IN
973	976	its	its	PRP$
977	985	complete	complete	JJ
986	997	degradation	degradation	NN
997	998	.	.	.

999	1009	Activation	Activation	NNP
1010	1012	of	of	IN
1013	1029	Ca(2+)-dependent	ca(2+)-dependent	JJ
1030	1038	pathways	pathway	NNS
1039	1044	alone	alone	RB
1045	1047	do	do	VBP
1048	1051	not	not	RB
1052	1058	result	result	VB
1059	1061	in	in	IN
1062	1065	the	the	DT
1066	1081	phosphorylation	phosphorylation	NN
1082	1088	and/or	and/or	CC
1089	1100	degradation	degradation	NN
1101	1103	of	of	IN
1104	1107	IkB	IkB	NNP
1108	1113	alpha	alpha	NN
1114	1116	in	in	IN
1117	1123	Jurkat	Jurkat	NNP
1124	1125	T	t	NN
1126	1128	or	or	CC
1129	1131	in	in	IN
1132	1136	U937	u937	NN
1137	1142	cells	cell	NNS
1142	1143	.	.	.

1144	1153	Treatment	Treatment	NNP
1154	1156	of	of	IN
1157	1158	T	t	NN
1159	1164	cells	cell	NNS
1165	1169	with	with	IN
1170	1173	the	the	DT
1174	1183	selective	selective	JJ
1184	1187	PKC	PKC	NNP
1188	1197	inhibitor	inhibitor	NN
1198	1207	GF109203X	GF109203X	NNP
1208	1217	abrogates	abrogate	VBZ
1218	1221	the	the	DT
1222	1233	PMA-induced	pma-induced	JJ
1234	1237	IkB	IkB	NNP
1238	1243	alpha	alpha	NN
1244	1271	phosphorylation/degradation	phosphorylation/degradation	NN
1272	1284	irrespective	irrespective	JJ
1285	1287	of	of	IN
1288	1298	activation	activation	NN
1299	1301	of	of	IN
1302	1318	Ca(2+)-dependent	ca(2+)-dependent	JJ
1319	1327	pathways	pathway	NNS
1327	1328	,	,	,
1329	1332	but	but	CC
1333	1336	not	not	RB
1337	1340	the	the	DT
1341	1356	phosphorylation	phosphorylation	NN
1357	1360	and	and	CC
1361	1372	degradation	degradation	NN
1373	1375	of	of	IN
1376	1379	IkB	IkB	NNP
1380	1385	alpha	alpha	NN
1386	1393	induced	induce	VBN
1394	1396	by	by	IN
1397	1406	TNF-alpha	TNF-alpha	NNP
1406	1407	,	,	,
1408	1409	a	a	DT
1410	1425	PKC-independent	pkc-independent	JJ
1426	1434	stimulus	stimulus	NN
1434	1435	.	.	.

1436	1444	Contrary	contrary	JJ
1445	1447	to	to	TO
1448	1451	the	the	DT
1452	1463	interaction	interaction	NN
1464	1468	with	with	IN
1469	1472	PKC	PKC	NNP
1472	1473	,	,	,
1474	1490	Ca(2+)-dependent	ca(2+)-dependent	JJ
1491	1499	pathways	pathway	NNS
1500	1509	synergize	synergize	VBP
1510	1514	with	with	IN
1515	1524	TNF-alpha	TNF-alpha	NNP
1525	1528	not	not	RB
1529	1531	at	at	IN
1532	1535	the	the	DT
1536	1541	level	level	NN
1542	1544	of	of	IN
1545	1548	IkB	IkB	NNP
1549	1554	alpha	alpha	NN
1555	1570	phosphorylation	phosphorylation	NN
1570	1571	,	,	,
1572	1575	but	but	CC
1576	1578	at	at	IN
1579	1582	the	the	DT
1583	1588	level	level	NN
1589	1591	of	of	IN
1592	1595	its	its	PRP$
1596	1607	degradation	degradation	NN
1607	1608	.	.	.

1609	1614	These	these	DT
1615	1622	results	result	NNS
1623	1631	indicate	indicate	VBP
1632	1636	that	that	IN
1637	1653	Ca(2+)-dependent	ca(2+)-dependent	JJ
1654	1662	pathways	pathway	NNS
1662	1663	,	,	,
1664	1673	including	include	VBG
1674	1677	the	the	DT
1678	1689	phosphatase	phosphatase	NN
1690	1701	calcineurin	calcineurin	NN
1701	1702	,	,	,
1703	1714	participate	participate	VBP
1715	1717	in	in	IN
1718	1721	the	the	DT
1722	1732	regulation	regulation	NN
1733	1735	of	of	IN
1736	1744	NF-kappa	NF-kappa	NNP
1745	1746	B	B	NNP
1747	1749	in	in	IN
1750	1751	a	a	DT
1752	1756	cell	cell	NN
1757	1765	specific	specific	JJ
1766	1773	fashion	fashion	NN
1774	1777	and	and	CC
1778	1787	synergize	synergize	VB
1788	1792	with	with	IN
1793	1806	PKC-dependent	pkc-dependent	JJ
1807	1810	and	and	CC
1811	1823	-independent	-independent	JJ
1824	1832	pathways	pathway	NNS
1833	1835	at	at	IN
1836	1839	the	the	DT
1840	1845	level	level	NN
1846	1848	of	of	IN
1849	1852	IkB	IkB	NNP
1853	1858	alpha	alpha	NN
1859	1874	phosphorylation	phosphorylation	NN
1875	1878	and	and	CC
1879	1890	degradation	degradation	NN
1890	1891	.	.	.