0 12 Thapsigargin thapsigargin NN 13 20 induces induce VBZ 21 25 IL-2 il-2 NN 26 34 receptor receptor NN 35 46 alpha-chain alpha-chain NN 47 49 in in IN 50 55 human human JJ 56 66 peripheral peripheral JJ 67 70 and and CC 71 77 Jurkat jurkat NN 78 79 T t NN 80 85 cells cell NNS 86 89 via via IN 90 91 a a DT 92 99 protein protein NN 100 106 kinase kinase NNP 107 120 C-independent c-independent JJ 121 130 mechanism mechanism NN 130 131 . . . 133 145 Thapsigargin Thapsigargin NNP 146 147 ( ( ( 147 149 TG TG NNP 149 150 ) ) ) 150 151 , , , 152 154 an an DT 155 164 inhibitor inhibitor NN 165 167 of of IN 168 181 Ca(2+)-ATPase Ca(2+)-ATPase NNP 181 182 , , , 183 191 depletes deplete VBZ 192 205 intracellular intracellular JJ 206 210 Ca2+ ca2+ NN 211 217 stores store NNS 218 221 and and CC 222 229 induces induce VBZ 230 231 a a DT 232 241 sustained sustained JJ 242 246 Ca2+ ca2+ NN 247 253 influx influx NN 254 261 without without IN 262 270 altering alter VBG 271 283 phosphatidyl phosphatidyl JJ 284 292 inositol inositol NN 293 299 levels level NNS 299 300 . . . 301 303 TG TG NNP 304 308 plus plus CC 309 316 phorbol phorbol NN 317 326 myristate myristate NN 327 334 acetate acetate NN 335 336 ( ( ( 336 339 PMA PMA NNP 339 340 ) ) ) 341 344 but but CC 345 348 not not RB 349 351 TG tg NN 352 357 alone alone RB 358 365 induced induce VBD 366 370 IL-2 il-2 NN 371 373 in in IN 374 380 Jurkat Jurkat NNP 381 382 T t NN 383 388 cells cell NNS 388 389 , , , 390 400 suggesting suggest VBG 401 405 that that IN 406 408 TG TG NNP 409 412 had have VBD 413 415 no no DT 416 422 effect effect NN 423 425 on on IN 426 433 protein protein NN 434 440 kinase kinase NNP 441 442 C C NNP 443 444 ( ( ( 444 447 PKC PKC NNP 447 448 ) ) ) 448 449 . . . 450 457 However however RB 457 458 , , , 459 461 TG TG NNP 462 469 induced induce VBD 470 479 increases increase NNS 480 482 in in IN 483 488 IL-2R IL-2R NNP 489 494 alpha alpha NN 495 502 protein protein NN 503 505 as as RB 506 510 well well RB 511 513 as as IN 514 519 IL-2R IL-2R NNP 520 525 alpha alpha NN 526 530 mRNA mrna NN 531 533 in in IN 534 540 Jurkat Jurkat NNP 541 542 T t NN 543 548 cells cell NNS 549 551 in in IN 552 553 a a DT 554 568 dose-dependent dose-dependent JJ 569 575 manner manner NN 575 576 . . . 577 578 A a DT 579 586 similar similar JJ 587 595 increase increase NN 596 598 in in IN 599 604 IL-2R IL-2R NNP 605 610 alpha alpha NN 611 613 by by IN 614 616 TG TG NNP 617 620 was be VBD 621 625 also also RB 626 634 observed observe VBN 635 637 in in IN 638 643 human human JJ 644 654 peripheral peripheral JJ 655 656 T t NN 657 662 cells cell NNS 662 663 . . . 664 671 Further further RB 671 672 , , , 673 677 like like IN 678 681 PMA PMA NNP 681 682 , , , 683 685 TG TG NNP 686 694 markedly markedly RB 695 702 induced induce VBD 703 705 NF NF NNP 706 711 kappa kappa NN 712 713 B B NNP 714 716 in in IN 717 723 Jurkat Jurkat NNP 724 725 T t NN 726 731 cells cell NNS 731 732 . . . 733 740 However however RB 740 741 , , , 742 744 TG TG NNP 745 748 and and CC 749 752 PMA PMA NNP 753 762 exhibited exhibit VBD 763 764 a a DT 765 776 synergistic synergistic JJ 777 783 action action NN 784 786 on on IN 787 792 IL-2R IL-2R NNP 793 798 alpha alpha NN 799 809 expression expression NN 809 810 , , , 811 821 suggesting suggest VBG 822 826 that that IN 827 829 TG TG NNP 830 833 and and CC 834 837 PMA PMA NNP 838 844 induce induce VBP 845 850 IL-2R il-2r NN 851 856 alpha alpha NN 857 864 through through IN 865 873 distinct distinct JJ 874 882 pathways pathway NNS 882 883 . . . 884 888 PMA- PMA- NNP 889 892 but but CC 893 896 not not RB 897 907 TG-induced tg-induced JJ 908 913 IL-2R IL-2R NNP 914 919 alpha alpha NN 920 922 is be VBZ 923 932 inhibited inhibit VBN 933 935 by by IN 936 939 the the DT 940 943 PKC PKC NNP 944 953 inhibitor inhibitor NN 954 956 H7 h7 NN 956 957 , , , 958 965 whereas whereas IN 966 969 TG- TG- NNP 970 973 but but CC 974 977 not not RB 978 989 PMA-induced pma-induced JJ 990 995 IL-2R IL-2R NNP 996 1001 alpha alpha NN 1002 1005 was be VBD 1006 1015 inhibited inhibit VBN 1016 1018 by by IN 1019 1026 cholera cholera NN 1027 1032 toxin toxin NN 1032 1033 , , , 1034 1043 forskolin forskolin NN 1044 1047 and and CC 1048 1059 1,9-dideoxy 1,9-dideoxy JJ 1060 1069 forskolin forskolin NN 1069 1070 . . . 1071 1073 In in IN 1074 1078 toto toto NN 1078 1079 , , , 1080 1085 these these DT 1086 1093 results result NNS 1094 1101 suggest suggest VBP 1102 1106 that that IN 1107 1109 TG TG NNP 1110 1117 induces induce VBZ 1118 1123 IL-2R il-2r NN 1124 1129 alpha alpha NN 1130 1132 in in IN 1133 1138 human human JJ 1139 1140 T t NN 1141 1146 cells cell NNS 1147 1154 through through IN 1155 1156 a a DT 1157 1172 PKC-independent pkc-independent JJ 1173 1180 pathway pathway NN 1180 1181 . . .