0 10 Functional functional JJ 11 16 roles role NNS 17 19 of of IN 20 23 the the DT 24 37 transcription transcription NN 38 44 factor factor NN 45 51 Oct-2A Oct-2A NNP 52 55 and and CC 56 59 the the DT 60 64 high high JJ 65 73 mobility mobility NN 74 79 group group NN 80 87 protein protein NN 88 91 I/Y i/y NN 92 94 in in IN 95 102 HLA-DRA HLA-DRA NNP 103 107 gene gene NN 108 118 expression expression NN 118 119 . . . 121 124 The the DT 125 130 class class NN 131 133 II ii CD 134 139 major major JJ 140 158 histocompatibility histocompatibility NN 159 166 complex complex NN 167 171 gene gene NN 172 179 HLA-DRA HLA-DRA NNP 180 182 is be VBZ 183 192 expressed express VBN 193 195 in in IN 196 197 B B NNP 198 203 cells cell NNS 203 204 , , , 205 214 activated activate VBN 215 216 T t NN 217 228 lymphocytes lymphocyte NNS 228 229 , , , 230 233 and and CC 234 236 in in IN 237 255 antigen-presenting antigen-presenting JJ 256 261 cells cell NNS 261 262 . . . 263 265 In in IN 266 274 addition addition NN 274 275 , , , 276 283 HLA-DRA HLA-DRA NNP 284 288 gene gene NN 289 299 expression expression NN 300 302 is be VBZ 303 312 inducible inducible JJ 313 315 in in IN 316 317 a a DT 318 325 variety variety NN 326 328 of of IN 329 333 cell cell NN 334 339 types type NNS 340 342 by by IN 343 359 interferon-gamma interferon-gamma NN 360 361 ( ( ( 361 370 IFN-gamma IFN-gamma NNP 370 371 ) ) ) 371 372 . . . 373 377 Here here RB 378 380 we we PRP 381 385 show show VBP 386 390 that that IN 391 394 the the DT 395 412 lymphoid-specific lymphoid-specific JJ 413 426 transcription transcription NN 427 433 factor factor NN 434 440 Oct-2A Oct-2A NNP 441 446 plays play VBZ 447 448 a a DT 449 457 critical critical JJ 458 462 role role NN 463 465 in in IN 466 473 HLA-DRA HLA-DRA NNP 474 478 gene gene NN 479 489 expression expression NN 490 492 in in IN 493 498 class class NN 499 510 II-positive ii-positive JJ 511 512 B B NNP 513 517 cell cell NN 518 523 lines line NNS 523 524 , , , 525 528 and and CC 529 533 that that IN 534 537 the the DT 538 542 high high JJ 543 551 mobility mobility NN 552 557 group group NN 558 565 protein protein NN 566 567 ( ( ( 567 570 HMG HMG NNP 570 571 ) ) ) 572 575 I/Y I/Y NNP 576 581 binds bind VBZ 582 584 to to TO 585 593 multiple multiple JJ 594 599 sites site NNS 600 606 within within IN 607 610 the the DT 611 614 DRA DRA NNP 615 623 promoter promoter NN 623 624 , , , 625 634 including include VBG 635 638 the the DT 639 645 Oct-2A Oct-2A NNP 646 653 binding binding NN 654 658 site site NN 658 659 . . . 660 672 Coexpression Coexpression NNP 673 675 of of IN 676 679 HMG HMG NNP 680 683 I/Y I/Y NNP 684 687 and and CC 688 693 Oct-2 oct-2 NN 694 696 in in IN 697 701 cell cell NN 702 707 lines line NNS 708 715 lacking lack VBG 716 721 Oct-2 oct-2 NN 722 729 results result VBZ 730 732 in in IN 733 737 high high JJ 738 744 levels level NNS 745 747 of of IN 748 755 HLA-DRA HLA-DRA NNP 756 760 gene gene NN 761 771 expression expression NN 771 772 , , , 773 776 and and CC 777 779 in in FW 780 785 vitro vitro FW 786 797 DNA-binding dna-binding JJ 798 805 studies study NNS 806 812 reveal reveal VBP 813 817 that that IN 818 821 HMG HMG NNP 822 825 I/Y I/Y NNP 826 836 stimulates stimulate VBZ 837 843 Oct-2A Oct-2A NNP 844 851 binding binding NN 852 854 to to TO 855 858 the the DT 859 866 HLA-DRA HLA-DRA NNP 867 875 promoter promoter NN 875 876 . . . 877 881 Thus thus RB 881 882 , , , 883 889 Oct-2A Oct-2A NNP 890 893 and and CC 894 897 HMG HMG NNP 898 901 I/Y I/Y NNP 902 905 may may MD 906 915 synergize synergize VB 916 918 to to TO 919 927 activate activate VB 928 935 HLA-DRA HLA-DRA NNP 936 946 expression expression NN 947 949 in in IN 950 951 B B NNP 952 957 cells cell NNS 957 958 . . . 959 961 By by IN 962 970 contrast contrast NN 970 971 , , , 972 978 Oct-2A Oct-2A NNP 979 981 is be VBZ 982 985 not not RB 986 994 involved involve VBN 995 997 in in IN 998 1001 the the DT 1002 1011 IFN-gamma IFN-gamma NNP 1012 1021 induction induction NN 1022 1024 of of IN 1025 1028 the the DT 1029 1036 HLA-DRA HLA-DRA NNP 1037 1041 gene gene NN 1042 1044 in in IN 1045 1049 HeLa HeLa NNP 1050 1055 cells cell NNS 1055 1056 , , , 1057 1060 but but CC 1061 1070 antisense antisense JJ 1071 1074 HMG HMG NNP 1075 1078 I/Y I/Y NNP 1079 1091 dramatically dramatically RB 1092 1101 decreases decrease VBZ 1102 1105 the the DT 1106 1111 level level NN 1112 1114 of of IN 1115 1124 induction induction NN 1124 1125 . . . 1126 1128 We we PRP 1129 1137 conclude conclude VBP 1138 1142 that that IN 1143 1151 distinct distinct JJ 1152 1156 sets set NNS 1157 1159 of of IN 1160 1173 transcription transcription NN 1174 1181 factors factor NNS 1182 1185 are be VBP 1186 1194 involved involve VBN 1195 1197 in in IN 1198 1201 the the DT 1202 1205 two two CD 1206 1211 modes mode NNS 1212 1214 of of IN 1215 1222 HLA-DRA HLA-DRA NNP 1223 1233 expression expression NN 1233 1234 , , , 1235 1238 and and CC 1239 1243 that that IN 1244 1247 HMG HMG NNP 1248 1251 I/Y I/Y NNP 1252 1255 may may MD 1256 1258 be be VB 1259 1268 important important JJ 1269 1272 for for IN 1273 1274 B B NNP 1275 1288 cell-specific cell-specific JJ 1289 1299 expression expression NN 1299 1300 , , , 1301 1304 and and CC 1305 1307 is be VBZ 1308 1317 essential essential JJ 1318 1321 for for IN 1322 1331 IFN-gamma IFN-gamma NNP 1332 1341 induction induction NN 1341 1342 . . .