0 10 Functional functional JJ 11 21 antagonism antagonism NN 22 29 between between IN 30 37 vitamin vitamin NN 38 40 D3 d3 NN 41 44 and and CC 45 53 retinoic retinoic JJ 54 58 acid acid NN 59 61 in in IN 62 65 the the DT 66 76 regulation regulation NN 77 79 of of IN 80 84 CD14 cd14 NN 85 88 and and CC 89 93 CD23 cd23 NN 94 104 expression expression NN 105 111 during during IN 112 121 monocytic monocytic JJ 122 137 differentiation differentiation NN 138 140 of of IN 141 146 U-937 u-937 NN 147 152 cells cell NNS 152 153 . . . 155 159 1,25 1,25 CD 160 190 alpha-Dihydroxicholecalciferol alpha-dihydroxicholecalciferol NN 191 192 ( ( ( 192 197 VitD3 VitD3 NNP 197 198 ) ) ) 199 202 and and CC 203 211 retinoic retinoic JJ 212 216 acid acid NN 217 218 ( ( ( 218 220 RA RA NNP 220 221 ) ) ) 222 225 are be VBP 226 235 important important JJ 236 246 regulators regulator NNS 247 249 of of IN 250 253 the the DT 254 267 proliferation proliferation NN 268 271 and and CC 272 287 differentiation differentiation NN 288 290 of of IN 291 298 several several JJ 299 303 cell cell NN 304 309 types type NNS 309 310 . . . 311 315 This this DT 316 321 paper paper NN 322 331 describes describe VBZ 332 335 how how WRB 336 339 the the DT 340 350 expression expression NN 351 353 of of IN 354 357 the the DT 358 377 monocyte-macrophage monocyte-macrophage JJ 378 380 Ag Ag NNP 380 381 , , , 382 386 CD14 cd14 NN 386 387 , , , 388 391 and and CC 392 395 the the DT 396 399 low low JJ 400 408 affinity affinity NN 409 411 Fc fc NN 412 420 receptor receptor NN 421 424 for for IN 425 428 IgE IgE NNP 428 429 , , , 430 434 CD23 CD23 NNP 434 435 , , , 436 440 were be VBD 441 450 inversely inversely RB 451 460 regulated regulate VBN 461 467 during during IN 468 474 VitD3- VitD3- NNP 475 478 and and CC 479 489 RA-induced ra-induced JJ 490 499 monocytic monocytic JJ 500 515 differentiation differentiation NN 516 518 of of IN 519 524 human human JJ 525 530 U-937 u-937 NN 531 541 monoblasts monoblast NNS 541 542 . . . 543 546 PMA PMA NNP 547 554 induced induce VBD 555 558 the the DT 559 569 expression expression NN 570 572 of of IN 573 577 both both CC 578 582 CD14 cd14 NN 583 586 and and CC 587 591 CD23 CD23 NNP 592 596 mRNA mRNA NNP 597 600 and and CC 601 608 protein protein NN 608 609 . . . 610 618 Exposure exposure NN 619 621 to to TO 622 627 VitD3 VitD3 NNP 628 635 rapidly rapidly RB 636 643 induced induce VBD 644 647 the the DT 648 650 de de FW 651 655 novo novo FW 656 666 expression expression NN 667 669 of of IN 670 674 CD14 cd14 NN 675 679 mRNA mRNA NNP 680 683 and and CC 684 691 protein protein NN 691 692 . . . 693 696 The the DT 697 705 addition addition NN 706 708 of of IN 709 722 cycloheximide cycloheximide NN 723 733 completely completely RB 734 741 blocked block VBD 742 745 the the DT 746 751 VitD3 vitd3 NN 752 761 induction induction NN 762 764 of of IN 765 769 CD14 cd14 NN 770 774 mRNA mrna NN 775 785 expression expression NN 785 786 , , , 787 797 indicating indicate VBG 798 802 that that IN 803 806 the the DT 807 816 induction induction NN 817 820 was be VBD 821 830 dependent dependent JJ 831 833 on on IN 834 841 ongoing ongoing JJ 842 849 protein protein NN 850 859 synthesis synthesis NN 859 860 . . . 861 866 While while IN 867 875 inducing induce VBG 876 880 CD14 cd14 NN 881 891 expression expression NN 891 892 , , , 893 898 VitD3 VitD3 NNP 899 912 concomitantly concomitantly RB 913 923 suppressed suppress VBD 924 927 the the DT 928 933 basal basal JJ 933 934 , , , 935 939 PMA- pma- NN 939 940 , , , 941 944 and and CC 945 957 RA-inducible ra-inducible JJ 958 962 CD23 cd23 NN 963 973 expression expression NN 974 976 in in IN 977 978 a a DT 979 993 dose-dependent dose-dependent JJ 994 1000 manner manner NN 1000 1001 . . . 1002 1004 In in IN 1005 1013 contrast contrast NN 1013 1014 , , , 1015 1020 U-937 u-937 NN 1021 1026 cells cell NNS 1027 1034 induced induce VBN 1035 1037 by by IN 1038 1040 RA RA NNP 1041 1049 strongly strongly RB 1050 1059 increased increase VBD 1060 1065 their their PRP$ 1066 1076 expression expression NN 1077 1079 of of IN 1080 1084 CD23 CD23 NNP 1085 1089 mRNA mRNA NNP 1090 1093 and and CC 1094 1101 protein protein NN 1101 1102 , , , 1103 1110 whereas whereas IN 1111 1115 they they PRP 1116 1126 completely completely RB 1127 1133 lacked lack VBD 1134 1144 detectable detectable JJ 1145 1149 CD14 cd14 NN 1150 1154 cell cell NN 1155 1162 surface surface NN 1163 1165 or or CC 1166 1170 mRNA mrna NN 1171 1181 expression expression NN 1181 1182 . . . 1183 1194 Furthermore furthermore RB 1194 1195 , , , 1196 1199 the the DT 1200 1206 VitD3- vitd3- NN 1207 1210 and and CC 1211 1214 the the DT 1215 1226 PMA-induced pma-induced JJ 1227 1231 CD14 cd14 NN 1232 1242 expression expression NN 1243 1246 was be VBD 1247 1256 inhibited inhibit VBN 1257 1259 as as IN 1260 1261 a a DT 1262 1270 temporal temporal JJ 1271 1282 consequence consequence NN 1283 1285 of of IN 1286 1289 the the DT 1290 1300 RA-induced ra-induced JJ 1301 1316 differentiation differentiation NN 1316 1317 . . . 1318 1321 The the DT 1322 1329 results result NNS 1330 1337 suggest suggest VBP 1338 1342 that that IN 1343 1348 there there EX 1349 1355 exists exist VBZ 1356 1357 a a DT 1358 1368 functional functional JJ 1369 1379 antagonism antagonism NN 1380 1387 between between IN 1388 1393 VitD3 VitD3 NNP 1394 1397 and and CC 1398 1400 RA RA NNP 1401 1405 that that WDT 1406 1409 may may MD 1410 1414 have have VB 1415 1424 important important JJ 1425 1437 implications implication NNS 1438 1441 for for IN 1442 1445 the the DT 1446 1456 regulation regulation NN 1457 1459 of of IN 1460 1467 certain certain JJ 1468 1474 immune immune JJ 1475 1478 and and CC 1479 1491 inflammatory inflammatory JJ 1492 1501 responses response NNS 1502 1509 through through IN 1510 1515 their their PRP$ 1516 1523 inverse inverse JJ 1524 1531 effects effect NNS 1532 1534 on on IN 1535 1539 CD14 cd14 NN 1540 1543 and and CC 1544 1548 CD23 cd23 NN 1549 1553 gene gene NN 1554 1564 expression expression NN 1564 1565 . . .