0 11 Association Association NNP 12 14 of of IN 15 26 alterations alteration NNS 27 29 in in IN 30 38 NF-kappa NF-kappa NNP 39 40 B B NNP 41 49 moieties moiety NNS 50 54 with with IN 55 58 HIV HIV NNP 59 63 type type NN 64 65 1 1 CD 66 74 proviral proviral JJ 75 82 latency latency NN 83 85 in in IN 86 93 certain certain JJ 94 103 monocytic monocytic JJ 104 109 cells cell NNS 109 110 . . . 112 117 Human human JJ 118 134 immunodeficiency immunodeficiency NN 135 140 virus virus NN 141 145 type type NN 146 147 1 1 CD 148 149 ( ( ( 149 154 HIV-1 HIV-1 NNP 154 155 ) ) ) 156 167 replication replication NN 168 170 is be VBZ 171 181 controlled control VBN 182 184 by by IN 185 186 a a DT 187 194 complex complex JJ 195 200 array array NN 201 203 of of IN 204 211 virally virally RB 212 219 encoded encode VBN 220 223 and and CC 224 232 cellular cellular JJ 233 241 proteins protein NNS 241 242 . . . 243 244 A a DT 245 249 wide wide JJ 250 258 spectrum spectrum NN 259 261 of of IN 262 268 levels level NNS 269 271 of of IN 272 277 HIV-1 HIV-1 NNP 278 288 expression expression NN 289 293 have have VBP 294 298 been be VBN 299 311 demonstrated demonstrate VBN 312 314 in in IN 315 322 various various JJ 323 328 cells cell NNS 328 329 , , , 330 334 both both CC 335 337 in in IN 338 342 cell cell NN 343 350 culture culture NN 351 354 and and CC 355 357 in in FW 358 362 vivo vivo FW 362 363 . . . 364 373 Molecular molecular JJ 374 384 mechanisms mechanism NNS 385 392 leading lead VBG 393 395 to to TO 396 406 restricted restricted JJ 407 412 HIV-1 HIV-1 NNP 413 424 replication replication NN 425 428 may may MD 429 435 differ differ VB 436 443 between between IN 444 451 certain certain JJ 452 456 cell cell NN 457 462 types type NNS 462 463 . . . 464 466 It it PRP 467 469 is be VBZ 470 473 now now RB 474 486 demonstrated demonstrate VBN 487 491 that that IN 492 497 HIV-1 HIV-1 NNP 498 506 proviral proviral JJ 507 514 latency latency NN 515 517 in in IN 518 521 the the DT 522 531 monocytic monocytic JJ 532 536 cell cell NN 537 541 line line NN 542 544 U1 u1 NN 544 545 , , , 546 548 in in IN 549 554 which which WDT 555 559 only only RB 560 569 extremely extremely RB 570 573 low low JJ 574 580 levels level NNS 581 583 of of IN 584 589 HIV-1 HIV-1 NNP 590 600 expression expression NN 601 604 are be VBP 605 613 detected detect VBN 614 616 in in IN 617 620 the the DT 621 629 baseline baseline NN 630 642 unstimulated unstimulated JJ 643 648 state state NN 648 649 , , , 650 652 is be VBZ 653 663 associated associate VBN 664 668 with with IN 669 680 alterations alteration NNS 681 683 in in IN 684 691 nuclear nuclear JJ 692 704 factor-kappa factor-kappa NN 705 706 B B NNP 707 708 ( ( ( 708 716 NF-kappa NF-kappa NNP 717 718 B B NNP 718 719 ) ) ) 720 728 moieties moiety NNS 729 741 demonstrated demonstrate VBD 742 744 in in IN 745 750 these these DT 751 756 cells cell NNS 757 759 by by IN 760 775 electrophoretic electrophoretic JJ 776 784 mobility mobility NN 785 790 shift shift NN 791 797 assays assay NNS 798 799 ( ( ( 799 804 EMSAs EMSA NNP 804 805 ) ) ) 806 809 and and CC 810 812 in in FW 813 817 situ situ FW 818 820 UV UV NNP 821 834 cross-linking cross-linking JJ 835 842 studies study NNS 842 843 . . . 844 845 A a DT 846 858 predominance predominance NN 859 861 of of IN 862 865 p50 p50 NN 866 874 NF-kappa NF-kappa NNP 875 876 B B NNP 877 885 moieties moiety NNS 886 889 and and CC 890 898 possibly possibly RB 899 902 p50 p50 NN 903 913 homodimers homodimer NNS 914 916 or or CC 917 924 closely closely RB 925 932 related related JJ 933 940 species specie NNS 940 941 , , , 942 948 rather rather RB 949 953 than than IN 954 957 the the DT 958 965 p50-p56 p50-p56 NN 966 977 heterodimer heterodimer NN 978 980 of of IN 981 989 NF-kappa NF-kappa NNP 990 991 B B NNP 992 996 that that WDT 997 999 is be VBZ 1000 1003 the the DT 1004 1015 predominant predominant JJ 1016 1024 NF-kappa NF-kappa NNP 1025 1026 B B NNP 1027 1034 species specie NNS 1035 1037 in in IN 1038 1042 most most JJS 1043 1044 T t NN 1045 1056 lymphocytic lymphocytic JJ 1057 1060 and and CC 1061 1070 monocytic monocytic JJ 1071 1076 cells cell NNS 1076 1077 , , , 1078 1080 is be VBZ 1081 1093 demonstrated demonstrate VBN 1094 1096 in in IN 1097 1100 the the DT 1101 1107 nuclei nucleus NNS 1108 1110 of of IN 1111 1113 U1 u1 NN 1114 1119 cells cell NNS 1119 1120 . . . 1121 1125 This this DT 1126 1133 pattern pattern NN 1134 1136 of of IN 1137 1145 NF-kappa NF-kappa NNP 1146 1155 B-related b-related JJ 1156 1164 moieties moiety NNS 1165 1172 differs differ VBZ 1173 1177 from from IN 1178 1181 the the DT 1182 1190 latently latently RB 1191 1199 infected infected JJ 1200 1201 T t NN 1202 1213 lymphocytic lymphocytic JJ 1214 1218 cell cell NN 1219 1223 line line NN 1224 1229 ACH-2 ach-2 NN 1229 1230 , , , 1231 1234 and and CC 1235 1239 from from IN 1240 1243 the the DT 1244 1248 U937 u937 NN 1249 1258 monocytic monocytic JJ 1259 1263 line line NN 1263 1264 , , , 1265 1268 the the DT 1269 1277 parental parental JJ 1278 1282 cell cell NN 1283 1287 line line NN 1288 1290 of of IN 1291 1294 the the DT 1295 1297 U1 u1 NN 1298 1306 cellular cellular JJ 1307 1312 clone clone NN 1312 1313 . . . 1314 1316 As as IN 1317 1321 such such JJ 1321 1322 , , , 1323 1328 these these DT 1329 1333 data datum NNS 1334 1341 suggest suggest VBP 1342 1346 that that IN 1347 1356 different different JJ 1357 1365 proximal proximal JJ 1366 1376 mechanisms mechanism NNS 1377 1380 may may MD 1381 1385 lead lead VB 1386 1388 to to TO 1389 1399 restricted restricted JJ 1400 1405 HIV-1 HIV-1 NNP 1406 1417 replication replication NN 1418 1420 in in IN 1421 1428 various various JJ 1429 1433 cell cell NN 1434 1439 types type NNS 1439 1440 . . .