0 22 Glucocorticoid-induced glucocorticoid-induced JJ 23 32 apoptosis apoptosis NN 33 35 of of IN 36 41 human human JJ 42 50 leukemic leukemic JJ 51 56 cells cell NNS 57 59 is be VBZ 60 66 caused cause VBN 67 69 by by IN 70 73 the the DT 74 84 repressive repressive JJ 85 93 function function NN 94 96 of of IN 97 100 the the DT 101 115 glucocorticoid glucocorticoid NN 116 124 receptor receptor NN 124 125 . . . 127 136 Induction Induction NNP 137 139 of of IN 140 149 apoptosis apoptosis NN 150 152 in in IN 153 164 lymphocytes lymphocyte NNS 164 165 , , , 166 171 which which WDT 172 175 may may MD 176 183 account account VB 184 187 for for IN 188 191 the the DT 192 203 therapeutic therapeutic JJ 204 211 effects effect NNS 212 214 of of IN 215 230 glucocorticoids glucocorticoid NNS 231 233 in in IN 234 241 various various JJ 242 250 diseases disease NNS 251 260 including include VBG 261 269 leukemia leukemia NN 269 270 , , , 271 278 depends depend VBZ 279 281 on on IN 282 285 the the DT 286 300 glucocorticoid glucocorticoid NN 301 309 receptor receptor NN 309 310 . . . 311 318 However however RB 318 319 , , , 320 323 the the DT 324 330 events event NNS 331 338 leading lead VBG 339 343 from from IN 344 347 the the DT 348 357 activated activate VBN 358 366 receptor receptor NN 367 369 to to TO 370 374 cell cell NN 375 380 lysis lysis NN 381 384 are be VBP 385 388 not not RB 389 399 understood understand VBN 399 400 . . . 401 402 A a DT 403 413 prevailing prevail VBG 414 424 hypothesis hypothesis NN 425 435 postulates postulate VBZ 436 445 induction induction NN 446 448 of of IN 449 458 so-called so-called JJ 459 460 ‘ ` `` 460 465 lysis lysis NN 466 471 genes gene NNS 471 472 ’ ' '' 473 475 by by IN 476 479 the the DT 480 489 activated activate VBN 490 498 receptor receptor NN 498 499 . . . 500 502 In in IN 503 507 this this DT 508 513 study study NN 513 514 , , , 515 517 we we PRP 518 522 show show VBP 523 527 that that IN 528 530 an an DT 531 551 activation-deficient activation-deficient JJ 552 566 glucocorticoid glucocorticoid NN 567 575 receptor receptor NN 576 582 mutant mutant NN 583 585 is be VBZ 586 588 as as RB 589 598 effective effective JJ 599 601 as as IN 602 605 the the DT 606 615 wild-type wild-type JJ 616 624 receptor receptor NN 625 627 in in IN 628 638 repression repression NN 639 641 of of IN 642 646 AP-1 ap-1 NN 647 655 activity activity NN 655 656 , , , 657 667 inhibition inhibition NN 668 670 of of IN 671 684 interleukin-2 interleukin-2 NN 685 695 production production NN 695 696 , , , 697 707 inhibition inhibition NN 708 710 of of IN 711 716 c-myc c-myc NN 717 727 expression expression NN 728 731 and and CC 732 741 induction induction NN 742 744 of of IN 745 754 apoptosis apoptosis NN 754 755 . . . 756 767 Furthermore furthermore RB 767 768 , , , 769 771 we we PRP 772 776 show show VBP 777 781 that that IN 782 790 retinoic retinoic JJ 791 795 acid acid NN 796 799 can can MD 800 804 also also RB 805 811 induce induce VB 812 821 apoptosis apoptosis NN 822 824 in in IN 825 830 these these DT 831 836 cells cell NNS 837 844 through through IN 845 848 the the DT 849 857 retinoic retinoic JJ 858 862 acid acid NN 863 871 receptor receptor NN 871 872 , , , 873 878 whose whose WP$ 879 889 repressive repressive JJ 890 899 functions function NNS 900 903 but but CC 904 907 not not RB 908 914 target target NN 915 919 site site NN 920 931 specificity specificity NN 931 932 , , , 933 936 are be VBP 937 944 similar similar JJ 945 947 to to TO 948 953 those those DT 954 956 of of IN 957 960 the the DT 961 975 glucocorticoid glucocorticoid NN 976 984 receptor receptor NN 984 985 . . . 986 995 Therefore therefore RB 995 996 , , , 997 1000 the the DT 1001 1008 primary primary JJ 1009 1015 effect effect NN 1016 1018 of of IN 1019 1022 the the DT 1023 1031 receptor receptor NN 1032 1034 in in IN 1035 1058 glucocorticoid-mediated glucocorticoid-mediated JJ 1059 1068 apoptosis apoptosis NN 1069 1079 correlates correlate VBZ 1080 1084 with with IN 1085 1100 transcriptional transcriptional JJ 1101 1111 repression repression NN 1112 1118 rather rather RB 1119 1123 than than IN 1124 1134 activation activation NN 1135 1138 and and CC 1139 1144 could could MD 1145 1147 be be VB 1148 1156 mediated mediate VBN 1157 1159 by by IN 1160 1172 interference interference NN 1173 1177 with with IN 1178 1183 other other JJ 1184 1197 transcription transcription NN 1198 1205 factors factor NNS 1206 1214 required require VBN 1215 1218 for for IN 1219 1223 cell cell NN 1224 1232 survival survival NN 1232 1233 . . .