0 10 Expression expression NN 11 13 of of IN 14 17 the the DT 18 22 Runt Runt NNP 23 38 domain-encoding domain-encoding JJ 39 44 PEBP2 pebp2 NN 45 50 alpha alpha NN 51 56 genes gene NNS 57 59 in in IN 60 61 T t NN 62 67 cells cell NNS 68 74 during during IN 75 81 thymic thymic JJ 82 93 development development NN 93 94 . . . 96 99 The the DT 100 105 PEBP2 pebp2 NN 106 111 alpha alpha NN 112 113 A a NN 114 117 and and CC 118 123 PEBP2 pebp2 NN 124 129 alpha alpha NN 130 131 B B NNP 132 137 genes gene NNS 138 144 encode encode VBP 145 148 the the DT 149 160 DNA-binding dna-binding JJ 161 168 subunit subunit NN 169 171 of of IN 172 173 a a DT 174 180 murine murine JJ 181 194 transcription transcription NN 195 201 factor factor NN 201 202 , , , 203 208 PEBP2 PEBP2 NNP 208 209 , , , 210 215 which which WDT 216 218 is be VBZ 219 229 implicated implicate VBN 230 232 as as IN 233 234 a a DT 235 250 T-cell-specific t-cell-specific JJ 251 266 transcriptional transcriptional JJ 267 276 regulator regulator NN 276 277 . . . 278 283 These these DT 284 287 two two CD 288 295 related related JJ 296 301 genes gene NNS 302 307 share share VBP 308 311 the the DT 312 326 evolutionarily evolutionarily RB 327 336 conserved conserve VBN 337 343 region region NN 344 352 encoding encode VBG 353 356 the the DT 357 361 Runt runt NN 362 368 domain domain NN 368 369 . . . 370 375 PEBP2 pebp2 NN 376 381 alpha alpha NN 382 383 B B NNP 384 386 is be VBZ 387 390 the the DT 391 397 murine murine JJ 398 409 counterpart counterpart NN 410 412 of of IN 413 418 human human JJ 419 423 AML1 aml1 NN 423 424 , , , 425 430 which which WDT 431 433 is be VBZ 434 441 located located JJ 442 444 at at IN 445 448 the the DT 449 460 breakpoints breakpoint NNS 461 463 of of IN 464 467 the the DT 468 472 8;21 8;21 CD 473 476 and and CC 477 481 3;21 3;21 CD 482 492 chromosome chromosome NN 493 507 translocations translocation NNS 508 518 associated associate VBN 519 523 with with IN 524 529 acute acute JJ 530 537 myeloid myeloid JJ 538 546 leukemia leukemia NN 546 547 . . . 548 556 Northern Northern NNP 557 558 ( ( ( 558 561 RNA RNA NNP 561 562 ) ) ) 563 568 blots blot NNS 569 571 of of IN 572 579 various various JJ 580 585 adult adult JJ 586 591 mouse mouse NN 592 599 tissues tissue NNS 600 608 revealed reveal VBD 609 613 that that IN 614 617 the the DT 618 624 levels level NNS 625 627 of of IN 628 638 expression expression NN 639 641 of of IN 642 646 both both DT 647 652 genes gene NNS 653 657 were be VBD 658 662 most most RBS 663 672 prominent prominent JJ 673 675 in in IN 676 679 the the DT 680 686 thymus thymus NN 686 687 . . . 688 699 Furthermore furthermore RB 699 700 , , , 701 712 transcripts transcript NNS 713 715 of of IN 716 721 PEBP2 pebp2 NN 722 727 alpha alpha NN 728 729 A a NN 730 733 and and CC 734 739 mouse mouse NN 740 750 AML1/PEBP2 aml1/pebp2 NN 751 756 alpha alpha NN 757 758 B B NNP 759 763 were be VBD 764 772 detected detect VBN 773 775 in in IN 776 777 T t NN 778 789 lymphocytes lymphocyte NNS 790 792 in in IN 793 796 the the DT 797 805 thymuses thymus NNS 806 810 from from IN 811 814 day day NN 815 817 16 16 CD 818 825 embryos embryo NNS 826 829 and and CC 830 838 newborns newborn NNS 838 839 , , , 840 842 as as RB 843 847 well well RB 848 850 as as IN 851 861 4-week-old 4-week-old JJ 862 867 adult adult JJ 868 872 mice mouse NNS 872 873 , , , 874 876 by by IN 877 879 in in FW 880 884 situ situ FW 885 898 hybridization hybridization NN 898 899 . . . 900 903 The the DT 904 914 expression expression NN 915 917 of of IN 918 921 the the DT 922 927 genes gene NNS 928 937 persisted persist VBD 938 940 in in IN 941 951 peripheral peripheral JJ 952 957 lymph lymph NN 958 963 nodes node NNS 964 966 of of IN 967 972 adult adult JJ 973 977 mice mouse NNS 977 978 . . . 979 982 The the DT 983 994 transcripts transcript NNS 995 999 were be VBD 1000 1008 detected detect VBN 1009 1011 in in IN 1012 1015 all all PDT 1016 1019 the the DT 1020 1024 CD4- cd4- JJ 1025 1029 CD8- cd8- JJ 1029 1030 , , , 1031 1035 CD4+ cd4+ JJ 1036 1040 CD8+ cd8+ JJ 1040 1041 , , , 1042 1046 CD4+ cd4+ JJ 1047 1051 CD8- CD8- NNP 1051 1052 , , , 1053 1056 and and CC 1057 1061 CD4- cd4- JJ 1062 1066 CD8+ cd8+ JJ 1067 1071 cell cell NN 1072 1083 populations population NNS 1083 1084 . . . 1085 1088 The the DT 1089 1096 results result NNS 1097 1106 indicated indicate VBD 1107 1111 that that IN 1112 1116 both both DT 1117 1122 genes gene NNS 1123 1126 are be VBP 1127 1136 expressed express VBN 1137 1139 in in IN 1140 1141 T t NN 1142 1147 cells cell NNS 1148 1158 throughout throughout IN 1159 1164 their their PRP$ 1165 1176 development development NN 1176 1177 , , , 1178 1188 supporting support VBG 1189 1192 the the DT 1193 1199 notion notion NN 1200 1204 that that IN 1205 1210 PEBP2 pebp2 NN 1211 1213 is be VBZ 1214 1215 a a DT 1216 1231 T-cell-specific t-cell-specific JJ 1232 1245 transcription transcription NN 1246 1252 factor factor NN 1252 1253 . . . 1254 1265 Transcripts transcript NNS 1266 1268 of of IN 1269 1274 mouse mouse NN 1275 1285 AML1/PEBP2 aml1/pebp2 NN 1286 1291 alpha alpha NN 1292 1293 B B NNP 1294 1298 were be VBD 1299 1303 also also RB 1304 1312 detected detect VBN 1313 1315 in in IN 1316 1319 day day NN 1320 1322 12 12 CD 1323 1328 fetal fetal JJ 1329 1342 hematopoietic hematopoietic JJ 1343 1348 liver liver NN 1349 1352 and and CC 1353 1355 in in IN 1356 1359 the the DT 1360 1364 bone bone NN 1365 1371 marrow marrow NN 1372 1377 cells cell NNS 1378 1380 of of IN 1381 1388 newborn newborn JJ 1389 1393 mice mouse NNS 1393 1394 . . . 1395 1398 The the DT 1399 1410 implication implication NN 1411 1413 of of IN 1414 1419 mouse mouse NN 1420 1430 AML1/PEBP2 aml1/pebp2 NN 1431 1436 alpha alpha NN 1437 1438 B B NNP 1439 1449 expression expression NN 1450 1452 in in IN 1453 1466 hematopoietic hematopoietic JJ 1467 1472 cells cell NNS 1473 1478 other other JJ 1479 1483 than than IN 1484 1489 those those DT 1490 1492 of of IN 1493 1499 T-cell t-cell NN 1500 1507 lineage lineage NN 1508 1510 is be VBZ 1511 1520 discussed discuss VBN 1521 1523 in in IN 1524 1532 relation relation NN 1533 1535 to to TO 1536 1543 myeloid myeloid JJ 1544 1558 leukemogenesis leukemogenesis NN 1558 1559 . . .