0 7 Control Control NNP 8 10 of of IN 11 12 I i NN 13 18 kappa kappa NN 19 26 B-alpha B-alpha NNP 27 38 proteolysis proteolysis NN 39 41 by by IN 42 55 site-specific site-specific JJ 55 56 , , , 57 71 signal-induced signal-induced JJ 72 87 phosphorylation phosphorylation NN 87 88 . . . 90 91 I i NN 92 97 kappa kappa NN 98 105 B-alpha B-alpha NNP 106 114 inhibits inhibit VBZ 115 128 transcription transcription NN 129 135 factor factor NN 136 144 NF-kappa NF-kappa NNP 145 146 B B NNP 147 149 by by IN 150 159 retaining retain VBG 160 162 it it PRP 163 165 in in IN 166 169 the the DT 170 179 cytoplasm cytoplasm NN 179 180 . . . 181 188 Various various JJ 189 196 stimuli stimulus NNS 196 197 , , , 198 207 typically typically RB 208 213 those those DT 214 224 associated associate VBN 225 229 with with IN 230 236 stress stress NN 237 239 or or CC 240 249 pathogens pathogen NNS 249 250 , , , 251 258 rapidly rapidly RB 259 269 inactivate inactivate VBP 270 271 I i NN 272 277 kappa kappa NN 278 285 B-alpha B-alpha NNP 285 286 . . . 287 291 This this DT 292 301 liberates liberate VBZ 302 310 NF-kappa NF-kappa NNP 311 312 B B NNP 313 315 to to TO 316 327 translocate translocate VB 328 330 to to TO 331 334 the the DT 335 342 nucleus nucleus NN 343 346 and and CC 347 355 initiate initiate VB 356 369 transcription transcription NN 370 372 of of IN 373 378 genes gene NNS 379 388 important important JJ 389 392 for for IN 393 396 the the DT 397 404 defense defense NN 405 407 of of IN 408 411 the the DT 412 420 organism organism NN 420 421 . . . 422 432 Activation Activation NNP 433 435 of of IN 436 444 NF-kappa NF-kappa NNP 445 446 B B NNP 447 457 correlates correlate VBZ 458 462 with with IN 463 478 phosphorylation phosphorylation NN 479 481 of of IN 482 483 I i NN 484 489 kappa kappa NN 490 497 B-alpha B-alpha NNP 498 501 and and CC 502 510 requires require VBZ 511 514 the the DT 515 526 proteolysis proteolysis NN 527 529 of of IN 530 534 this this DT 535 544 inhibitor inhibitor NN 544 545 . . . 546 550 When when WRB 551 557 either either CC 558 567 serine-32 serine-32 NN 568 570 or or CC 571 580 serine-36 serine-36 NN 581 583 of of IN 584 585 I i NN 586 591 kappa kappa NN 592 599 B-alpha B-alpha NNP 600 603 was be VBD 604 611 mutated mutate VBN 611 612 , , , 613 616 the the DT 617 624 protein protein NN 625 628 did do VBD 629 632 not not RB 633 640 undergo undergo VB 641 655 signal-induced signal-induced JJ 656 671 phosphorylation phosphorylation NN 672 674 or or CC 675 686 degradation degradation NN 686 687 , , , 688 691 and and CC 692 700 NF-kappa NF-kappa NNP 701 702 B B NNP 703 708 could could MD 709 712 not not RB 713 715 be be VB 716 725 activated activate VBN 725 726 . . . 727 732 These these DT 733 740 results result NNS 741 748 suggest suggest VBP 749 753 that that IN 754 769 phosphorylation phosphorylation NN 770 772 at at IN 773 776 one one CD 777 779 or or CC 780 784 both both DT 785 787 of of IN 788 793 these these DT 794 802 residues residue NNS 803 805 is be VBZ 806 814 critical critical JJ 815 818 for for IN 819 829 activation activation NN 830 832 of of IN 833 841 NF-kappa NF-kappa NNP 842 843 B B NNP 843 844 . . .