0	7	Effects	Effect	NNPS
8	10	of	of	IN
11	15	CD45	CD45	NNP
16	18	on	on	IN
19	27	NF-kappa	NF-kappa	NNP
28	30	B.	B.	NNP
31	43	Implications	implication	NNS
44	47	for	for	IN
48	59	replication	replication	NN
60	62	of	of	IN
63	68	HIV-1	HIV-1	NNP
68	69	.	.	.

71	80	Increased	increase	VBN
81	87	levels	level	NNS
88	90	of	of	IN
91	102	replication	replication	NN
103	105	of	of	IN
106	109	the	the	DT
110	113	HIV	HIV	NNP
114	118	type	type	NN
119	120	1	1	CD
121	124	are	be	VBP
125	133	observed	observe	VBN
134	139	after	after	IN
140	143	the	the	DT
144	154	activation	activation	NN
155	157	of	of	IN
158	166	infected	infected	JJ
167	168	T	t	NN
169	174	cells	cell	NNS
175	182	through	through	IN
183	186	the	the	DT
187	190	TCR	TCR	NNP
190	191	.	.	.

192	199	However	however	RB
199	200	,	,	,
201	210	anti-CD45	anti-cd45	JJ
211	221	antibodies	antibody	NNS
222	229	inhibit	inhibit	VBP
230	235	these	these	DT
236	243	effects	effect	NNS
244	246	in	in	IN
247	252	cells	cell	NNS
253	257	from	from	IN
258	266	infected	infected	JJ
267	278	individuals	individual	NNS
278	279	.	.	.

280	282	In	in	IN
283	287	this	this	DT
288	293	study	study	NN
293	294	,	,	,
295	297	we	we	PRP
298	306	examined	examine	VBD
307	325	interrelationships	interrelationship	NNS
326	333	between	between	IN
334	338	CD45	CD45	NNP
339	342	and	and	CC
343	348	HIV-1	HIV-1	NNP
349	356	further	further	RB
356	357	.	.	.

358	360	We	we	PRP
361	369	measured	measure	VBD
370	377	effects	effect	NNS
378	380	on	on	IN
381	384	the	the	DT
385	390	HIV-1	HIV-1	NNP
391	394	LTR	LTR	NNP
395	397	in	in	IN
398	399	T	t	NN
400	404	cell	cell	NN
405	410	lines	line	NNS
411	415	that	that	WDT
416	420	were	be	VBD
421	431	stimulated	stimulate	VBN
432	436	with	with	IN
437	447	antibodies	antibody	NNS
448	455	against	against	IN
456	460	CD45	CD45	NNP
461	464	and	and	CC
465	467	in	in	IN
468	473	those	those	DT
474	478	that	that	WDT
479	485	lacked	lack	VBD
486	489	the	the	DT
490	500	expression	expression	NN
501	503	of	of	IN
504	508	CD45	CD45	NNP
509	511	on	on	IN
512	517	their	their	PRP$
518	526	surfaces	surface	NNS
526	527	.	.	.

528	533	First	first	RB
533	534	,	,	,
535	544	anti-CD45	anti-cd45	JJ
545	555	antibodies	antibody	NNS
556	559	did	do	VBD
560	563	not	not	RB
564	570	affect	affect	VB
571	576	basal	basal	JJ
577	580	but	but	CC
581	590	decreased	decrease	VBD
591	600	activated	activate	VBN
601	607	levels	level	NNS
608	610	of	of	IN
611	621	expression	expression	NN
622	626	from	from	IN
627	630	the	the	DT
631	636	HIV-1	HIV-1	NNP
637	640	LTR	LTR	NNP
640	641	.	.	.

642	648	Second	second	RB
648	649	,	,	,
650	651	T	t	NN
652	657	cells	cell	NNS
657	658	,	,	,
659	664	which	which	WDT
665	669	lack	lack	VBP
670	674	CD45	cd45	NN
675	678	and	and	CC
679	685	cannot	cannot	NN
686	692	signal	signal	NN
693	696	via	via	IN
697	700	the	the	DT
701	704	TCR	TCR	NNP
704	705	,	,	,
706	715	supported	support	VBD
716	722	higher	high	JJR
723	729	levels	level	NNS
730	732	of	of	IN
733	738	viral	viral	JJ
739	750	replication	replication	NN
751	754	and	and	CC
755	759	gene	gene	NN
760	770	expression	expression	NN
770	771	.	.	.

772	776	This	this	DT
777	780	was	be	VBD
781	784	due	due	JJ
785	787	to	to	TO
788	791	the	the	DT
792	800	presence	presence	NN
801	803	of	of	IN
804	810	active	active	JJ
811	819	NF-kappa	NF-kappa	NNP
820	821	B	B	NNP
822	831	complexes	complex	NNS
832	834	in	in	IN
835	838	the	the	DT
839	846	nucleus	nucleus	NN
847	849	of	of	IN
850	855	CD45-	cd45-	NN
856	857	T	t	NN
858	863	cells	cell	NNS
863	864	.	.	.

865	877	Additionally	additionally	RB
877	878	,	,	,
879	887	infected	infected	JJ
888	889	T	t	NN
890	895	cells	cell	NNS
896	905	displayed	display	VBD
906	911	lower	low	JJR
912	918	levels	level	NNS
919	921	of	of	IN
922	926	CD45	CD45	NNP
927	929	on	on	IN
930	935	their	their	PRP$
936	944	surfaces	surface	NNS
944	945	.	.	.

946	950	Thus	thus	RB
950	951	,	,	,
952	956	CD45	CD45	NNP
957	962	plays	play	VBZ
963	965	an	an	DT
966	972	active	active	JJ
973	977	role	role	NN
978	980	in	in	IN
981	984	the	the	DT
985	995	physiology	physiology	NN
996	998	of	of	IN
999	1000	T	t	NN
1001	1006	cells	cell	NNS
1007	1010	and	and	CC
1011	1013	in	in	IN
1014	1017	the	the	DT
1018	1029	replication	replication	NN
1030	1032	of	of	IN
1033	1038	HIV-1	HIV-1	NNP
1038	1039	.	.	.