0 7 Signals signal NNS 8 18 transduced transduce VBN 19 26 through through IN 27 30 the the DT 31 34 CD4 cd4 NN 35 43 molecule molecule NN 44 46 on on IN 47 48 T t NN 49 60 lymphocytes lymphocyte NNS 61 69 activate activate VBP 70 78 NF-kappa NF-kappa NNP 79 81 B. B. NNP 83 85 We we PRP 86 90 have have VBP 91 103 demonstrated demonstrate VBN 104 108 that that IN 109 115 native native JJ 116 124 envelope envelope NN 125 138 glycoproteins glycoprotein NNS 139 141 of of IN 142 147 HIV-1 HIV-1 NNP 147 148 , , , 149 154 gp160 gp160 NN 155 158 can can MD 159 165 induce induce VB 166 176 activation activation NN 177 179 of of IN 180 183 the the DT 184 197 transcription transcription NN 198 204 factor factor NN 204 205 , , , 206 214 NF-kappa NF-kappa NNP 215 217 B. B. NNP 218 221 The the DT 222 233 stimulatory stimulatory JJ 234 241 effects effect NNS 242 244 of of IN 245 250 gp160 gp160 NN 251 254 are be VBP 255 263 mediated mediate VBN 264 271 through through IN 272 275 the the DT 276 279 CD4 cd4 NN 280 288 molecule molecule NN 288 289 , , , 290 295 since since IN 296 308 pretreatment pretreatment NN 309 313 with with IN 314 321 soluble soluble JJ 322 325 CD4 cd4 NN 326 335 abrogates abrogate VBZ 336 339 its its PRP$ 340 348 activity activity NN 348 349 . . . 350 353 The the DT 354 367 gp160-induced gp160-induced JJ 368 376 NF-kappa NF-kappa NNP 377 378 B B NNP 379 386 complex complex NN 387 395 consists consist VBZ 396 398 of of IN 399 402 p65 p65 NN 402 403 , , , 404 407 p50 p50 NN 408 411 and and CC 412 417 c-rel c-rel NN 418 426 proteins protein NNS 426 427 . . . 428 431 The the DT 432 443 stimulatory stimulatory JJ 444 450 effect effect NN 451 453 of of IN 454 459 gp160 gp160 NN 460 462 on on IN 463 471 NF-kappa NF-kappa NNP 472 473 B B NNP 474 484 activation activation NN 485 487 is be VBZ 488 495 protein protein NN 496 505 synthesis synthesis NN 506 517 independent independent JJ 517 518 , , , 519 521 is be VBZ 522 531 dependent dependent JJ 532 536 upon upon IN 537 544 protein protein NN 545 553 tyrosine tyrosine NN 554 569 phosphorylation phosphorylation NN 569 570 , , , 571 574 and and CC 575 584 abrogated abrogate VBN 585 587 by by IN 588 598 inhibitors inhibitor NNS 599 601 of of IN 602 609 protein protein NN 610 616 kinase kinase NNP 617 618 C C NNP 618 619 . . . 620 623 The the DT 624 638 gp160-mediated gp160-mediated JJ 639 649 activation activation NN 650 652 of of IN 653 661 NF-kappa NF-kappa NNP 662 663 B B NNP 664 666 in in IN 667 670 CD4 CD4 NNP 671 679 positive positive JJ 680 681 T t NN 682 687 cells cell NNS 688 691 may may MD 692 694 be be VB 695 703 involved involve VBN 704 706 in in IN 707 717 biological biological JJ 718 725 effects effect NNS 725 726 , , , 727 731 e.g. e.g. FW 731 732 , , , 733 741 enhanced enhance VBN 742 745 HIV HIV NNP 746 757 replication replication NN 757 758 , , , 759 781 hypergammaglobulinemia hypergammaglobulinemia NN 781 782 , , , 783 792 increased increase VBD 793 801 cytokine cytokine NN 802 811 secretion secretion NN 811 812 , , , 813 829 hypercellularity hypercellularity NN 830 832 in in IN 833 837 bone bone NN 838 844 marrow marrow NN 845 848 and and CC 849 858 apoptosis apoptosis NN 858 859 . . .