0 8 Arrested arrest VBN 9 20 development development NN 20 21 : : : 22 35 understanding understand VBG 36 41 v-abl v-abl NN 41 42 . . . 44 47 The the DT 48 55 protein protein NN 56 64 tyrosine tyrosine NN 65 71 kinase kinase NNP 72 80 activity activity NN 81 83 of of IN 84 87 the the DT 88 93 v-abl v-abl NN 94 102 oncogene oncogene NN 103 106 has have VBZ 107 111 been be VBN 112 124 demonstrated demonstrate VBN 125 127 to to TO 128 135 subvert subvert VB 136 139 the the DT 140 146 normal normal JJ 147 153 second second JJ 154 163 messenger messenger NN 164 171 systems system NNS 172 176 used use VBN 177 179 by by IN 180 188 lymphoid lymphoid JJ 189 194 cells cell NNS 195 198 for for IN 199 205 growth growth NN 206 209 and and CC 210 225 differentiation differentiation NN 225 226 . . . 227 241 Transformation transformation NN 242 244 of of IN 245 249 bone bone NN 250 256 marrow marrow NN 257 261 with with IN 262 265 the the DT 266 273 Abelson Abelson NNP 274 280 murine murine JJ 281 289 leukemia leukemia NN 290 295 virus virus NN 296 303 results result VBZ 304 306 in in IN 307 310 the the DT 311 321 appearance appearance NN 322 324 of of IN 325 326 B B NNP 327 331 cell cell NN 332 339 lineage lineage NN 340 345 cells cell NNS 346 354 arrested arrest VBN 355 357 at at IN 358 361 the the DT 362 367 pre-B pre-b JJ 368 372 cell cell NN 373 378 stage stage NN 378 379 . . . 380 386 Recent recent JJ 387 394 reports report NNS 395 399 have have VBP 400 413 characterized characterize VBN 414 419 these these DT 420 425 cells cell NNS 426 436 expressing express VBG 437 441 high high JJ 442 447 v-abl v-abl NN 448 454 kinase kinase NNP 455 463 activity activity NN 464 466 as as IN 467 476 deficient deficient JJ 477 479 in in IN 480 490 detectable detectable JJ 491 500 NF-kappaB NF-kappaB NNP 501 504 DNA DNA NNP 505 512 binding binding NN 513 521 activity activity NN 522 525 and and CC 526 529 low low JJ 530 535 level level NN 536 539 RAG rag NN 540 544 gene gene NN 545 555 expression expression NN 555 556 . . . 557 562 These these DT 563 575 observations observation NNS 576 583 suggest suggest VBP 584 588 that that IN 589 594 v-abl v-abl NN 595 598 may may MD 599 601 be be VB 602 612 inhibiting inhibit VBG 613 616 the the DT 617 632 differentiation differentiation NN 633 635 of of IN 636 637 B B NNP 638 643 cells cell NNS 644 646 by by IN 647 655 blocking block VBG 656 661 these these DT 662 665 two two CD 666 673 crucial crucial JJ 674 682 elements element NNS 683 685 in in IN 686 689 the the DT 690 700 maturation maturation NN 701 708 pathway pathway NN 708 709 . . .