0	3	One	one	CD
4	8	gene	gene	NN
8	9	,	,	,
10	13	two	two	CD
14	25	transcripts	transcript	NNS
25	26	:	:	:
27	36	isolation	isolation	NN
37	39	of	of	IN
40	42	an	an	DT
43	54	alternative	alternative	JJ
55	65	transcript	transcript	NN
66	74	encoding	encode	VBG
75	78	for	for	IN
79	82	the	the	DT
83	94	autoantigen	autoantigen	NN
95	102	La/SS-B	la/ss-b	NN
103	107	from	from	IN
108	109	a	a	DT
110	114	cDNA	cdna	NN
115	122	library	library	NN
123	125	of	of	IN
126	127	a	a	DT
128	135	patient	patient	NN
136	140	with	with	IN
141	148	primary	primary	JJ
149	157	Sjogrens	Sjogrens	NNP
157	158	’	'	POS
159	167	syndrome	syndrome	NN
167	168	.	.	.

170	171	A	a	DT
172	176	cDNA	cdna	NN
177	184	library	library	NN
185	188	was	be	VBD
189	197	prepared	prepare	VBN
198	202	from	from	IN
203	213	peripheral	peripheral	JJ
214	219	blood	blood	NN
220	231	lymphocytes	lymphocyte	NNS
232	234	of	of	IN
235	237	an	an	DT
238	248	autoimmune	autoimmune	JJ
249	256	patient	patient	NN
257	261	with	with	IN
262	269	primary	primary	JJ
270	278	Sjogrens	Sjogrens	NNP
278	279	’	'	POS
280	288	syndrome	syndrome	NN
288	289	.	.	.

290	293	The	the	DT
294	298	cDNA	cdna	NN
299	306	library	library	NN
307	310	was	be	VBD
311	319	screened	screen	VBN
320	324	with	with	IN
325	328	the	the	DT
329	337	patients	patient	NNS
338	341	own	own	VBP
342	352	autoimmune	autoimmune	JJ
353	358	serum	serum	NN
359	364	being	be	VBG
365	377	monospecific	monospecific	JJ
378	381	for	for	IN
382	385	the	the	DT
386	393	nuclear	nuclear	JJ
394	405	autoantigen	autoantigen	NN
406	413	La/SS-B	la/ss-b	NN
413	414	.	.	.

415	422	Thereby	thereby	RB
423	425	an	an	DT
426	437	alternative	alternative	JJ
438	442	type	type	NN
443	445	of	of	IN
446	448	La	La	NNP
449	453	mRNA	mRNA	NNP
454	457	was	be	VBD
458	468	identified	identify	VBN
469	473	that	that	WDT
474	482	differed	differ	VBD
483	487	from	from	IN
488	491	the	the	DT
492	497	known	know	VBN
498	500	La	La	NNP
501	505	mRNA	mRNA	NNP
506	509	due	due	JJ
510	512	to	to	TO
513	515	an	an	DT
516	524	exchange	exchange	NN
525	527	of	of	IN
528	531	the	the	DT
532	536	exon	exon	NN
537	538	1	1	CD
538	539	.	.	.

540	550	Sequencing	sequencing	NN
551	553	of	of	IN
554	557	the	the	DT
558	565	genomic	genomic	JJ
566	572	region	region	NN
573	580	between	between	IN
581	584	the	the	DT
585	590	exons	exon	NNS
591	592	1	1	CD
593	596	and	and	CC
597	598	2	2	CD
599	605	showed	show	VBD
606	610	that	that	IN
611	614	the	the	DT
615	626	alternative	alternative	JJ
627	633	5’-end	5'-end	NN
634	636	is	be	VBZ
637	638	a	a	DT
639	643	part	part	NN
644	646	of	of	IN
647	650	the	the	DT
651	657	intron	intron	NN
657	658	.	.	.

659	661	In	in	IN
662	670	addition	addition	NN
670	671	,	,	,
672	675	the	the	DT
676	684	presence	presence	NN
685	687	of	of	IN
688	690	an	an	DT
691	702	alternative	alternative	JJ
703	711	promoter	promoter	NN
712	716	site	site	NN
716	717	,	,	,
718	723	which	which	WDT
724	730	exists	exist	VBZ
731	737	within	within	IN
738	741	the	the	DT
742	748	intron	intron	NN
749	759	downstream	downstream	RB
760	762	of	of	IN
763	766	the	the	DT
767	771	exon	exon	NN
772	773	1	1	CD
773	774	,	,	,
775	781	became	become	VBD
782	789	evident	evident	JJ
789	790	.	.	.

791	793	In	in	IN
794	805	consequence	consequence	NN
805	806	,	,	,
807	810	the	the	DT
811	822	alternative	alternative	JJ
823	825	La	La	NNP
826	830	mRNA	mRNA	NNP
831	833	is	be	VBZ
834	837	the	the	DT
838	844	result	result	NN
845	847	of	of	IN
848	849	a	a	DT
850	858	promoter	promoter	NN
859	868	switching	switching	NN
869	877	combined	combine	VBN
878	882	with	with	IN
883	885	an	an	DT
886	897	alternative	alternative	JJ
898	906	splicing	splicing	NN
907	916	mechanism	mechanism	NN
916	917	.	.	.

918	920	In	in	IN
921	924	the	the	DT
925	931	intron	intron	NN
931	932	,	,	,
933	940	further	further	JJ
941	954	transcription	transcription	NN
955	961	factor	factor	NN
962	969	binding	binding	NN
970	975	sites	site	NNS
975	976	,	,	,
977	986	including	include	VBG
987	988	a	a	DT
989	997	NF-kappa	NF-kappa	NNP
998	999	B	B	NNP
1000	1007	element	element	NN
1007	1008	,	,	,
1009	1013	were	be	VBD
1014	1024	identified	identify	VBN
1025	1032	leading	lead	VBG
1033	1035	to	to	TO
1036	1039	the	the	DT
1040	1050	suggestion	suggestion	NN
1051	1055	that	that	IN
1056	1059	the	the	DT
1060	1070	expression	expression	NN
1071	1073	of	of	IN
1074	1077	the	the	DT
1078	1082	gene	gene	NN
1083	1091	encoding	encode	VBG
1092	1095	for	for	IN
1096	1099	the	the	DT
1100	1107	nuclear	nuclear	JJ
1108	1119	autoantigen	autoantigen	NN
1120	1127	La/SS-B	la/ss-b	NN
1128	1134	alters	alter	VBZ
1135	1137	in	in	IN
1138	1148	dependence	dependence	NN
1149	1151	on	on	IN
1152	1159	disease	disease	NN
1160	1170	conditions	condition	NNS
1170	1171	.	.	.