0 22 Glucocorticoid-induced glucocorticoid-induced JJ 23 32 apoptosis apoptosis NN 33 35 of of IN 36 44 lymphoid lymphoid JJ 45 50 cells cell NNS 50 51 . . . 53 56 The the DT 57 66 induction induction NN 67 69 of of IN 70 74 cell cell NN 75 80 death death NN 81 83 in in IN 84 92 lymphoid lymphoid JJ 93 98 cells cell NNS 99 101 by by IN 102 117 glucocorticoids glucocorticoid NNS 118 120 is be VBZ 121 124 one one CD 125 127 of of IN 128 131 the the DT 132 140 earliest early JJS 141 144 and and CC 145 149 most most RBS 150 160 thoroughly thoroughly RB 161 168 studied study VBN 169 175 models model NNS 176 178 of of IN 179 188 apoptosis apoptosis NN 188 189 . . . 190 198 Although although IN 199 202 the the DT 203 208 exact exact JJ 209 218 mechanism mechanism NN 219 221 by by IN 222 227 which which WDT 228 237 apoptosis apoptosis NN 238 244 occurs occur VBZ 245 247 in in IN 248 259 lymphocytes lymphocyte NNS 260 262 is be VBZ 263 270 unknown unknown JJ 271 275 many many JJ 276 287 biochemical biochemical JJ 288 291 and and CC 292 301 molecular molecular JJ 302 309 changes change NNS 310 314 have have VBP 315 319 been be VBN 320 325 shown show VBN 326 328 to to TO 329 334 occur occur VB 335 337 in in IN 338 343 these these DT 344 349 cells cell NNS 350 352 in in IN 353 361 response response NN 362 364 to to TO 365 380 glucocorticoids glucocorticoid NNS 380 381 . . . 382 385 The the DT 386 390 role role NN 391 393 of of IN 394 403 chromatin chromatin NN 404 415 degradation degradation NN 416 419 and and CC 420 433 endonucleases endonucleas NNS 434 436 in in IN 437 440 the the DT 441 450 apoptotic apoptotic JJ 451 458 process process NN 459 462 has have VBZ 463 467 been be VBN 468 475 closely closely RB 476 483 studied study VBN 483 484 , , , 485 487 as as RB 488 492 well well RB 493 495 as as IN 496 499 the the DT 500 511 involvement involvement NN 512 514 of of IN 515 522 several several JJ 523 532 oncogenes oncogene NNS 533 535 in in IN 536 558 glucocorticoid-induced glucocorticoid-induced JJ 559 563 cell cell NN 564 569 lysis lysis NN 569 570 . . . 571 573 In in IN 574 582 addition addition NN 582 583 , , , 584 587 the the DT 588 596 clinical clinical JJ 597 607 importance importance NN 608 610 of of IN 611 633 glucocorticoid-induced glucocorticoid-induced JJ 634 643 apoptosis apoptosis NN 644 646 in in IN 647 650 the the DT 651 660 treatment treatment NN 661 663 of of IN 664 672 lymphoid lymphoid JJ 673 682 neoplasms neoplasm NNS 683 686 has have VBZ 687 695 recently recently RB 696 704 received receive VBN 705 714 increased increase VBN 715 724 attention attention NN 724 725 . . .