0 10 Inhibition Inhibition NNP 11 13 of of IN 14 22 NF-kappa NF-kappa NNP 23 24 B B NNP 25 27 by by IN 28 34 sodium sodium NN 35 45 salicylate salicylate NN 46 49 and and CC 50 57 aspirin aspirin NN 58 59 [ [ ( 59 62 see see VB 63 71 comments comment NNS 71 72 ] ] ) 74 77 The the DT 78 91 transcription transcription NN 92 98 factor factor NN 99 106 nuclear nuclear JJ 107 119 factor-kappa factor-kappa NN 120 121 B B NNP 122 123 ( ( ( 123 131 NF-kappa NF-kappa NNP 132 133 B B NNP 133 134 ) ) ) 135 137 is be VBZ 138 146 critical critical JJ 147 150 for for IN 151 154 the the DT 155 164 inducible inducible JJ 165 175 expression expression NN 176 178 of of IN 179 187 multiple multiple JJ 188 196 cellular cellular JJ 197 200 and and CC 201 206 viral viral JJ 207 212 genes gene NNS 213 221 involved involve VBN 222 224 in in IN 225 237 inflammation inflammation NN 238 241 and and CC 242 251 infection infection NN 252 261 including include VBG 262 275 interleukin-1 interleukin-1 NN 276 277 ( ( ( 277 281 IL-1 IL-1 NNP 281 282 ) ) ) 282 283 , , , 284 288 IL-6 IL-6 NNP 288 289 , , , 290 293 and and CC 294 302 adhesion adhesion NN 303 312 molecules molecule NNS 312 313 . . . 314 317 The the DT 318 335 anti-inflammatory anti-inflammatory JJ 336 341 drugs drug NNS 342 348 sodium sodium NN 349 359 salicylate salicylate NN 360 363 and and CC 364 371 aspirin aspirin NN 372 381 inhibited inhibit VBD 382 385 the the DT 386 396 activation activation NN 397 399 of of IN 400 408 NF-kappa NF-kappa NNP 409 410 B B NNP 410 411 , , , 412 417 which which WDT 418 425 further further RB 426 434 explains explain VBZ 435 438 the the DT 439 448 mechanism mechanism NN 449 451 of of IN 452 458 action action NN 459 461 of of IN 462 467 these these DT 468 473 drugs drug NNS 473 474 . . . 475 479 This this DT 480 490 inhibition inhibition NN 491 500 prevented prevent VBD 501 504 the the DT 505 516 degradation degradation NN 517 519 of of IN 520 523 the the DT 524 532 NF-kappa NF-kappa NNP 533 534 B B NNP 535 544 inhibitor inhibitor NN 544 545 , , , 546 547 I i NN 548 553 kappa kappa NN 554 555 B B NNP 555 556 , , , 557 560 and and CC 561 570 therefore therefore RB 571 579 NF-kappa NF-kappa NNP 580 581 B B NNP 582 585 was be VBD 586 594 retained retain VBN 595 597 in in IN 598 601 the the DT 602 609 cytosol cytosol NN 609 610 . . . 611 617 Sodium sodium NN 618 628 salicylate salicylate NN 629 632 and and CC 633 640 aspirin aspirin NN 641 645 also also RB 646 655 inhibited inhibit VBD 656 664 NF-kappa NF-kappa NNP 665 676 B-dependent b-dependent JJ 677 690 transcription transcription NN 691 695 from from IN 696 699 the the DT 700 702 Ig Ig NNP 703 708 kappa kappa NN 709 717 enhancer enhancer NN 718 721 and and CC 722 725 the the DT 726 731 human human JJ 732 748 immunodeficiency immunodeficiency NN 749 754 virus virus NN 755 756 ( ( ( 756 759 HIV HIV NNP 759 760 ) ) ) 761 765 long long JJ 766 774 terminal terminal JJ 775 781 repeat repeat NN 782 783 ( ( ( 783 786 LTR LTR NNP 786 787 ) ) ) 788 790 in in IN 791 802 transfected transfecte VBN 803 804 T t NN 805 810 cells cell NNS 810 811 . . .