0	10	Activation	Activation	NNP
11	13	of	of	IN
14	21	nuclear	nuclear	JJ
22	28	factor	factor	NN
29	34	kappa	kappa	NN
35	36	B	b	NN
37	39	in	in	IN
40	45	human	human	JJ
46	59	neuroblastoma	neuroblastoma	NN
60	64	cell	cell	NN
65	70	lines	line	NNS
70	71	.	.	.

73	76	The	the	DT
77	84	nuclear	nuclear	JJ
85	91	factor	factor	NN
92	97	kappa	kappa	NN
98	99	B	B	NNP
100	101	(	(	(
101	109	NF-kappa	NF-kappa	NNP
110	111	B	B	NNP
111	112	)	)	)
113	115	is	be	VBZ
116	117	a	a	DT
118	128	eukaryotic	eukaryotic	JJ
129	142	transcription	transcription	NN
143	149	factor	factor	NN
149	150	.	.	.

151	153	In	in	IN
154	155	B	B	NNP
156	161	cells	cell	NNS
162	165	and	and	CC
166	177	macrophages	macrophage	NNS
178	180	it	it	PRP
181	183	is	be	VBZ
184	198	constitutively	constitutively	RB
199	206	present	present	JJ
207	209	in	in	IN
210	214	cell	cell	NN
215	221	nuclei	nucleus	NNS
221	222	,	,	,
223	230	whereas	whereas	IN
231	233	in	in	IN
234	238	many	many	JJ
239	244	other	other	JJ
245	249	cell	cell	NN
250	255	types	type	NNS
255	256	,	,	,
257	265	NF-kappa	NF-kappa	NNP
266	267	B	B	NNP
268	280	translocates	translocate	VBZ
281	285	from	from	IN
286	293	cytosol	cytosol	NN
294	296	to	to	TO
297	304	nucleus	nucleus	NN
305	307	as	as	IN
308	309	a	a	DT
310	316	result	result	NN
317	319	of	of	IN
320	332	transduction	transduction	NN
333	335	by	by	IN
336	341	tumor	tumor	NN
342	350	necrosis	necrosis	NN
351	357	factor	factor	NN
358	363	alpha	alpha	NN
364	365	(	(	(
365	368	TNF	TNF	NNP
369	374	alpha	alpha	NN
374	375	)	)	)
375	376	,	,	,
377	384	phorbol	phorbol	NN
385	390	ester	ester	NN
390	391	,	,	,
392	395	and	and	CC
396	401	other	other	JJ
402	412	polyclonal	polyclonal	JJ
413	420	signals	signal	NNS
420	421	.	.	.

422	427	Using	use	VBG
428	441	neuroblastoma	neuroblastoma	NN
442	446	cell	cell	NN
447	452	lines	line	NNS
453	455	as	as	IN
456	462	models	model	NNS
462	463	,	,	,
464	466	we	we	PRP
467	471	have	have	VBP
472	477	shown	show	VBN
478	482	that	that	IN
483	485	in	in	IN
486	492	neural	neural	JJ
493	498	cells	cell	NNS
499	507	NF-kappa	NF-kappa	NNP
508	509	B	B	NNP
510	513	was	be	VBD
514	521	present	present	JJ
522	524	in	in	IN
525	528	the	the	DT
529	536	cytosol	cytosol	NN
537	540	and	and	CC
541	553	translocated	translocate	VBN
554	558	into	into	IN
559	565	nuclei	nucleus	NNS
566	568	as	as	IN
569	570	a	a	DT
571	577	result	result	NN
578	580	of	of	IN
581	584	TNF	TNF	NNP
585	590	alpha	alpha	NN
591	600	treatment	treatment	NN
600	601	.	.	.

602	605	The	the	DT
606	609	TNF	TNF	NNP
610	625	alpha-activated	alpha-activated	JJ
626	634	NF-kappa	NF-kappa	NNP
635	636	B	B	NNP
637	640	was	be	VBD
641	658	transcriptionally	transcriptionally	RB
659	669	functional	functional	JJ
669	670	.	.	.

671	679	NF-kappa	NF-kappa	NNP
680	681	B	B	NNP
682	692	activation	activation	NN
693	695	by	by	IN
696	699	TNF	TNF	NNP
700	705	alpha	alpha	NN
706	709	was	be	VBD
710	713	not	not	RB
714	724	correlated	correlate	VBN
725	729	with	with	IN
730	734	cell	cell	NN
735	750	differentiation	differentiation	NN
751	753	or	or	CC
754	767	proliferation	proliferation	NN
767	768	.	.	.

769	776	However	however	RB
776	777	,	,	,
778	786	reagents	reagent	NNS
787	791	such	such	JJ
792	794	as	as	IN
795	800	nerve	nerve	NN
801	807	growth	growth	NN
808	814	factor	factor	NN
815	816	(	(	(
816	819	NGF	NGF	NNP
819	820	)	)	)
821	824	and	and	CC
825	828	the	the	DT
829	836	phorbol	phorbol	NN
837	842	ester	ester	NN
843	850	phorbol	phorbol	NN
851	863	12-myristate	12-myristate	NN
864	874	13-acetate	13-acetate	NN
875	876	(	(	(
876	879	PMA	PMA	NNP
879	880	)	)	)
880	881	,	,	,
882	887	which	which	WDT
888	894	induce	induce	VBP
895	907	phenotypical	phenotypical	JJ
908	923	differentiation	differentiation	NN
924	926	of	of	IN
927	930	the	the	DT
931	938	SH-SY5Y	sh-sy5y	NN
939	952	neuroblastoma	neuroblastoma	NN
953	957	cell	cell	NN
958	962	line	line	NN
962	963	,	,	,
964	973	activated	activate	VBD
974	982	NF-kappa	NF-kappa	NNP
983	984	B	B	NNP
984	985	,	,	,
986	989	but	but	CC
990	994	only	only	RB
995	997	in	in	IN
998	1002	that	that	DT
1003	1013	particular	particular	JJ
1014	1018	cell	cell	NN
1019	1023	line	line	NN
1023	1024	.	.	.

1025	1027	In	in	IN
1028	1029	a	a	DT
1030	1044	NGF-responsive	ngf-responsive	JJ
1045	1048	rat	rat	NN
1049	1065	pheochromocytoma	pheochromocytoma	NN
1066	1070	cell	cell	NN
1071	1075	line	line	NN
1075	1076	,	,	,
1077	1081	PC12	PC12	NNP
1081	1082	,	,	,
1083	1086	PMA	PMA	NNP
1087	1096	activated	activate	VBD
1097	1105	NF-kappa	NF-kappa	NNP
1106	1107	B	B	NNP
1107	1108	,	,	,
1109	1116	whereas	whereas	IN
1117	1120	NGF	NGF	NNP
1121	1124	did	do	VBD
1125	1128	not	not	RB
1128	1129	.	.	.

1130	1132	In	in	IN
1133	1138	other	other	JJ
1139	1152	neuroblastoma	neuroblastoma	NN
1153	1157	cell	cell	NN
1158	1163	lines	line	NNS
1163	1164	,	,	,
1165	1169	such	such	JJ
1170	1172	as	as	IN
1173	1183	SK-N-Be(2)	SK-N-Be(2)	NNP
1183	1184	,	,	,
1185	1188	the	the	DT
1189	1193	lack	lack	NN
1194	1196	of	of	IN
1197	1200	PMA	PMA	NNP
1201	1210	induction	induction	NN
1211	1213	of	of	IN
1214	1229	differentiation	differentiation	NN
1230	1233	was	be	VBD
1234	1244	correlated	correlate	VBN
1245	1249	with	with	IN
1250	1253	the	the	DT
1254	1258	lack	lack	NN
1259	1261	of	of	IN
1262	1270	NF-kappa	NF-kappa	NNP
1271	1272	B	B	NNP
1273	1283	activation	activation	NN
1283	1284	.	.	.

1285	1287	We	we	PRP
1288	1293	found	find	VBD
1293	1294	,	,	,
1295	1303	moreover	moreover	RB
1303	1304	,	,	,
1305	1309	that	that	IN
1310	1312	in	in	IN
1313	1323	SK-N-Be(2)	sk-n-be(2)	NN
1324	1329	cells	cell	NNS
1330	1337	protein	protein	NN
1338	1344	kinase	kinase	NNP
1345	1346	C	C	NNP
1347	1348	(	(	(
1348	1351	PKC	PKC	NNP
1351	1352	)	)	)
1353	1362	enzymatic	enzymatic	JJ
1363	1371	activity	activity	NN
1372	1375	was	be	VBD
1376	1380	much	much	RB
1381	1386	lower	low	JJR
1387	1395	compared	compare	VBN
1396	1400	with	with	IN
1401	1405	that	that	DT
1406	1408	in	in	IN
1409	1410	a	a	DT
1411	1418	control	control	NN
1419	1423	cell	cell	NN
1424	1428	line	line	NN
1429	1432	and	and	CC
1433	1437	that	that	IN
1438	1441	the	the	DT
1442	1445	low	low	JJ
1446	1449	PKC	PKC	NNP
1450	1459	enzymatic	enzymatic	JJ
1460	1468	activity	activity	NN
1469	1472	was	be	VBD
1473	1476	due	due	JJ
1477	1479	to	to	TO
1480	1483	low	low	JJ
1484	1487	PKC	PKC	NNP
1488	1495	protein	protein	NN
1496	1506	expression	expression	NN
1506	1507	.	.	.

1508	1516	NF-kappa	NF-kappa	NNP
1517	1518	B	B	NNP
1519	1522	was	be	VBD
1523	1526	not	not	RB
1527	1536	activated	activate	VBN
1537	1539	by	by	IN
1540	1548	retinoic	retinoic	JJ
1549	1553	acid	acid	NN
1553	1554	,	,	,
1555	1560	which	which	WDT
1561	1568	induced	induce	VBD
1569	1582	morphological	morphological	JJ
1583	1598	differentiation	differentiation	NN
1599	1601	of	of	IN
1602	1605	all	all	PDT
1606	1609	the	the	DT
1610	1623	neuroblastoma	neuroblastoma	NN
1624	1628	cell	cell	NN
1629	1634	lines	line	NNS
1635	1639	used	use	VBN
1640	1642	in	in	IN
1643	1646	the	the	DT
1647	1654	present	present	JJ
1655	1660	study	study	NN
1660	1661	.	.	.

1662	1666	Thus	thus	RB
1666	1667	,	,	,
1668	1676	NF-kappa	NF-kappa	NNP
1677	1678	B	B	NNP
1679	1689	activation	activation	NN
1690	1693	was	be	VBD
1694	1697	not	not	RB
1698	1706	required	require	VBN
1707	1710	for	for	IN
1711	1724	neuroblastoma	neuroblastoma	NN
1725	1729	cell	cell	NN
1730	1745	differentiation	differentiation	NN
1745	1746	.	.	.

1747	1758	Furthermore	furthermore	RB
1758	1759	,	,	,
1760	1763	the	the	DT
1764	1771	results	result	NNS
1772	1780	obtained	obtain	VBN
1781	1785	with	with	IN
1786	1789	TNF	TNF	NNP
1790	1795	alpha	alpha	NN
1796	1802	proved	prove	VBD
1803	1807	that	that	IN
1808	1816	NF-kappa	NF-kappa	NNP
1817	1818	B	B	NNP
1819	1829	activation	activation	NN
1830	1833	was	be	VBD
1834	1837	not	not	RB
1838	1848	sufficient	sufficient	JJ
1849	1852	for	for	IN
1853	1862	induction	induction	NN
1863	1865	of	of	IN
1866	1879	neuroblastoma	neuroblastoma	NN
1880	1895	differentiation	differentiation	NN
1895	1896	.	.	.