0 1 A a DT 2 7 novel novel JJ 8 26 heterodimerization heterodimerization NN 27 34 partner partner NN 35 38 for for IN 39 46 thyroid thyroid NN 47 54 hormone hormone NN 55 63 receptor receptor NN 63 64 . . . 65 75 Peroxisome Peroxisome NNP 76 98 proliferator-activated proliferator-activated JJ 99 107 receptor receptor NN 107 108 . . . 110 123 Retinoid-like retinoid-like JJ 124 133 receptors receptor NNS 134 138 play play VBP 139 140 a a DT 141 148 central central JJ 149 153 role role NN 154 156 in in IN 157 165 hormonal hormonal JJ 166 175 responses response NNS 176 178 by by IN 179 186 forming form VBG 187 199 heterodimers heterodimer NNS 200 204 with with IN 205 210 other other JJ 211 218 nuclear nuclear JJ 219 226 hormone hormone NN 227 236 receptors receptor NNS 236 237 . . . 238 240 In in IN 241 245 this this DT 246 251 study study NN 252 254 we we PRP 255 259 have have VBP 260 270 identified identify VBN 271 274 the the DT 275 285 peroxisome peroxisome NN 286 308 proliferator-activated proliferator-activated JJ 309 317 receptor receptor NN 318 319 ( ( ( 319 323 PPAR PPAR NNP 323 324 ) ) ) 325 327 as as IN 328 329 a a DT 330 333 new new JJ 334 341 thyroid thyroid NN 342 349 hormone hormone NN 350 358 receptor receptor NN 359 360 ( ( ( 360 363 THR THR NNP 363 364 ) ) ) 365 374 auxiliary auxiliary JJ 375 382 nuclear nuclear JJ 383 390 protein protein NN 390 391 , , , 392 408 heterodimerizing heterodimerize VBG 409 413 with with IN 414 417 THR THR NNP 418 420 in in IN 421 429 solution solution NN 429 430 . . . 431 439 Although although IN 440 445 these these DT 446 458 heterodimers heterodimer NNS 459 461 do do VBP 462 465 not not RB 466 475 recognize recognize VB 476 477 a a DT 478 487 classical classical JJ 488 495 thyroid thyroid NN 496 503 hormone hormone NN 504 512 response response NN 513 520 element element NN 521 522 ( ( ( 522 525 TRE TRE NNP 525 526 ) ) ) 527 540 characterized characterize VBN 541 543 by by IN 544 550 direct direct JJ 551 557 repeat repeat NN 558 567 separated separate VBN 568 570 by by IN 571 575 four four CD 576 587 nucleotides nucleotide NNS 588 589 ( ( ( 589 593 DR+4 DR+4 NNP 593 594 ) ) ) 594 595 , , , 596 600 PPAR PPAR NNP 601 608 behaves behave VBZ 609 611 as as IN 612 613 a a DT 614 622 dominant dominant JJ 623 631 negative negative JJ 632 641 regulator regulator NN 642 644 of of IN 645 652 thyroid thyroid NN 653 660 hormone hormone NN 661 662 ( ( ( 662 664 TH TH NNP 664 665 ) ) ) 666 672 action action NN 672 673 . . . 674 681 However however RB 681 682 , , , 683 684 a a DT 685 697 TH-dependent th-dependent JJ 698 706 positive positive JJ 707 713 effect effect NN 714 716 is be VBZ 717 725 elicited elicit VBN 726 728 by by IN 729 738 selective selective JJ 739 750 interaction interaction NN 751 753 of of IN 754 757 the the DT 758 761 THR THR NNP 762 771 beta-PPAR beta-PPAR NNP 772 775 but but CC 776 779 not not RB 780 783 the the DT 784 787 THR THR NNP 788 798 alpha-PPAR alpha-PPAR NNP 799 810 heterodimer heterodimer NN 811 815 with with IN 816 817 a a DT 818 823 novel novel JJ 824 827 TRE TRE NNP 828 829 ( ( ( 829 833 DR+2 dr+2 NN 833 834 ) ) ) 834 835 . . . 836 839 The the DT 840 848 critical critical JJ 849 855 region region NN 856 858 of of IN 859 862 THR THR NNP 863 867 beta beta NN 868 871 was be VBD 872 878 mapped map VBN 879 881 to to TO 882 883 3 3 CD 884 889 amino amino NN 890 895 acids acid NNS 896 898 in in IN 899 902 the the DT 903 909 distal distal JJ 910 913 box box NN 914 916 of of IN 917 920 the the DT 921 924 DNA DNA NNP 925 932 binding binding NN 933 939 domain domain NN 939 940 . . . 941 946 Hence hence RB 946 947 , , , 948 952 PPAR PPAR NNP 953 956 can can MD 957 967 positively positively RB 968 970 or or CC 971 981 negatively negatively RB 982 991 influence influence VB 992 994 TH th NN 995 1001 action action NN 1002 1011 depending depend VBG 1012 1014 on on IN 1015 1018 TRE tre NN 1019 1028 structure structure NN 1029 1032 and and CC 1033 1036 THR THR NNP 1037 1044 isotype isotype NN 1044 1045 . . .