0 10 Activation Activation NNP 11 13 of of IN 14 21 nuclear nuclear JJ 22 28 factor factor NN 29 34 kappa kappa NN 35 36 B b NN 37 39 in in IN 40 45 human human JJ 46 60 lymphoblastoid lymphoblastoid JJ 61 66 cells cell NNS 67 69 by by IN 70 78 low-dose low-dose JJ 79 87 ionizing ionize VBG 88 97 radiation radiation NN 97 98 . . . 100 107 Nuclear nuclear JJ 108 114 factor factor NN 115 120 kappa kappa NN 121 122 B B NNP 123 124 ( ( ( 124 132 NF-kappa NF-kappa NNP 133 134 B B NNP 134 135 ) ) ) 136 138 is be VBZ 139 140 a a DT 141 152 pleiotropic pleiotropic JJ 153 166 transcription transcription NN 167 173 factor factor NN 174 179 which which WDT 180 182 is be VBZ 183 191 involved involve VBN 192 194 in in IN 195 198 the the DT 199 214 transcriptional transcriptional JJ 215 225 regulation regulation NN 226 228 of of IN 229 236 several several JJ 237 245 specific specific JJ 246 251 genes gene NNS 251 252 . . . 253 259 Recent recent JJ 260 267 reports report NNS 268 280 demonstrated demonstrate VBD 281 285 that that IN 286 294 ionizing ionize VBG 295 304 radiation radiation NN 305 307 in in IN 308 311 the the DT 312 316 dose dose NN 317 322 range range NN 323 325 of of IN 326 330 2-50 2-50 CD 331 333 Gy Gy NNP 334 341 results result VBZ 342 344 in in IN 345 355 expression expression NN 356 358 of of IN 359 367 NF-kappa NF-kappa NNP 368 369 B B NNP 370 372 in in IN 373 378 human human JJ 379 383 KG-1 kg-1 NN 384 391 myeloid myeloid JJ 392 400 leukemia leukemia NN 401 406 cells cell NNS 407 410 and and CC 411 416 human human JJ 417 429 B-lymphocyte b-lymphocyte NN 430 439 precursor precursor NN 440 445 cells cell NNS 445 446 ; ; : 447 450 the the DT 451 458 precise precise JJ 459 468 mechanism mechanism NN 469 477 involved involve VBN 478 481 and and CC 482 485 the the DT 486 498 significance significance NN 499 502 are be VBP 503 506 not not RB 507 510 yet yet RB 511 516 known know VBN 516 517 . . . 518 521 The the DT 522 529 present present JJ 530 536 report report NN 537 549 demonstrates demonstrate VBZ 550 554 that that IN 555 559 even even RB 560 565 lower low JJR 566 571 doses dose NNS 572 574 of of IN 575 583 ionizing ionize VBG 584 593 radiation radiation NN 593 594 , , , 595 603 0.25-2.0 0.25-2.0 CD 604 606 Gy Gy NNP 606 607 , , , 608 611 are be VBP 612 619 capable capable JJ 620 622 of of IN 623 631 inducing induce VBG 632 642 expression expression NN 643 645 of of IN 646 654 NF-kappa NF-kappa NNP 655 656 B B NNP 657 659 in in IN 660 675 EBV-transformed ebv-transformed JJ 676 680 244B 244b NN 681 686 human human JJ 687 701 lymphoblastoid lymphoblastoid JJ 702 707 cells cell NNS 707 708 . . . 709 714 These these DT 715 722 results result NNS 723 726 are be VBP 727 729 in in IN 730 731 a a DT 732 736 dose dose NN 737 742 range range NN 743 748 where where WRB 749 752 the the DT 753 762 viability viability NN 763 765 of of IN 766 769 the the DT 770 775 cells cell NNS 776 783 remains remain VBZ 784 788 very very RB 789 793 high high JJ 793 794 . . . 795 800 After after IN 801 809 exposure exposure NN 810 812 to to TO 813 818 137Cs 137c NNS 819 824 gamma gamma NN 825 829 rays ray NNS 830 832 at at IN 833 834 a a DT 835 839 dose dose NN 840 844 rate rate NN 845 847 of of IN 848 852 1.17 1.17 CD 853 859 Gy/min Gy/min NNP 859 860 , , , 861 862 a a DT 863 870 maximum maximum NN 871 873 in in IN 874 884 expression expression NN 885 887 of of IN 888 896 NF-kappa NF-kappa NNP 897 898 B B NNP 899 902 was be VBD 903 907 seen see VBN 908 910 at at IN 911 912 8 8 CD 913 914 h h NN 915 920 after after IN 921 922 a a DT 923 929 0.5-Gy 0.5-gy JJ 930 938 exposure exposure NN 938 939 . . . 940 951 Time-course time-course JJ 952 959 studies study NNS 960 968 revealed reveal VBD 969 970 a a DT 971 979 biphasic biphasic JJ 980 994 time-dependent time-dependent JJ 995 1005 expression expression NN 1006 1011 after after IN 1012 1016 0.5- 0.5- CD 1016 1017 , , , 1018 1020 1- 1- CD 1021 1024 and and CC 1025 1029 2-Gy 2-gy JJ 1030 1039 exposures exposure NNS 1039 1040 . . . 1041 1048 However however RB 1048 1049 , , , 1050 1053 for for IN 1054 1058 each each DT 1059 1063 time time NN 1064 1072 examined examine VBN 1072 1073 , , , 1074 1077 the the DT 1078 1088 expression expression NN 1089 1091 of of IN 1092 1100 NF-kappa NF-kappa NNP 1101 1102 B B NNP 1103 1106 was be VBD 1107 1114 maximum maximum JJ 1115 1120 after after IN 1121 1124 the the DT 1125 1131 0.5-Gy 0.5-gy JJ 1132 1140 exposure exposure NN 1140 1141 . . . 1142 1145 The the DT 1146 1156 expression expression NN 1157 1159 of of IN 1160 1163 the the DT 1164 1167 p50 p50 NN 1168 1171 and and CC 1172 1175 p65 p65 NN 1176 1184 NF-kappa NF-kappa NNP 1185 1186 B B NNP 1187 1195 subunits subunit NNS 1196 1199 was be VBD 1200 1204 also also RB 1205 1210 shown show VBN 1211 1213 to to TO 1214 1216 be be VB 1217 1226 regulated regulate VBN 1227 1241 differentially differentially RB 1242 1247 after after IN 1248 1257 exposures exposure NNS 1258 1260 to to TO 1261 1264 1.0 1.0 CD 1265 1268 and and CC 1269 1272 2.0 2.0 CD 1273 1275 Gy Gy NNP 1275 1276 . . .