0	11	Involvement	involvement	NN
12	14	of	of	IN
15	18	Alu	Alu	NNP
19	28	sequences	sequence	NNS
29	31	in	in	IN
32	35	the	the	DT
36	49	cell-specific	cell-specific	JJ
50	60	regulation	regulation	NN
61	63	of	of	IN
64	77	transcription	transcription	NN
78	80	of	of	IN
81	84	the	the	DT
85	90	gamma	gamma	NN
91	96	chain	chain	NN
97	99	of	of	IN
100	102	Fc	Fc	NNP
103	106	and	and	CC
107	108	T	t	NN
109	113	cell	cell	NN
114	123	receptors	receptor	NNS
123	124	.	.	.

126	129	The	the	DT
130	132	Fc	Fc	NNP
133	140	epsilon	epsilon	NN
141	149	RI-gamma	RI-gamma	NNP
150	156	chains	chain	NNS
157	160	are	be	VBP
161	170	expressed	express	VBN
171	173	in	in	IN
174	175	a	a	DT
176	183	variety	variety	NN
184	186	of	of	IN
187	200	hematopoietic	hematopoietic	JJ
201	206	cells	cell	NNS
207	212	where	where	WRB
213	217	they	they	PRP
218	222	play	play	VBP
223	224	a	a	DT
225	233	critical	critical	JJ
234	238	role	role	NN
239	241	in	in	IN
242	248	signal	signal	NN
249	261	transduction	transduction	NN
261	262	.	.	.

263	267	They	they	PRP
268	271	are	be	VBP
272	276	part	part	NN
277	279	of	of	IN
280	283	the	the	DT
284	288	high	high	JJ
289	297	affinity	affinity	NN
298	301	IgE	ige	NN
302	310	receptor	receptor	NN
311	313	in	in	IN
314	318	mast	mast	NN
319	324	cells	cell	NNS
324	325	,	,	,
326	335	basophils	basophil	NNS
335	336	,	,	,
337	347	Langerhans	Langerhans	NNP
348	353	cells	cell	NNS
353	354	,	,	,
355	358	and	and	CC
359	367	possibly	possibly	RB
368	373	other	other	JJ
374	379	cells	cell	NNS
379	380	;	;	:
381	382	a	a	DT
383	392	component	component	NN
393	395	of	of	IN
396	399	the	the	DT
400	403	low	low	JJ
404	412	affinity	affinity	NN
413	421	receptor	receptor	NN
422	425	for	for	IN
426	429	IgG	IgG	NNP
430	431	(	(	(
431	433	Fc	Fc	NNP
434	439	gamma	gamma	NN
440	445	RIIIA	RIIIA	NNP
446	448	or	or	CC
449	453	CD16	CD16	NNP
453	454	)	)	)
455	457	in	in	IN
458	465	natural	natural	JJ
466	472	killer	killer	NN
473	478	cells	cell	NNS
479	482	and	and	CC
483	494	macrophages	macrophage	NNS
494	495	;	;	:
496	499	and	and	CC
500	504	part	part	NN
505	507	of	of	IN
508	511	the	the	DT
512	513	T	t	NN
514	518	cell	cell	NN
519	526	antigen	antigen	NN
527	535	receptor	receptor	NN
536	538	in	in	IN
539	546	subsets	subset	NNS
547	549	of	of	IN
550	551	T	t	NN
552	557	cells	cell	NNS
557	558	.	.	.

559	563	Here	here	RB
564	566	we	we	PRP
567	571	have	have	VBP
572	584	investigated	investigate	VBN
585	588	the	the	DT
589	604	transcriptional	transcriptional	JJ
605	615	regulation	regulation	NN
616	618	of	of	IN
619	622	the	the	DT
623	628	gamma	gamma	NN
629	634	chain	chain	NN
635	639	gene	gene	NN
640	642	by	by	IN
643	652	analyzing	analyze	VBG
653	656	the	the	DT
657	669	2.5-kilobase	2.5-kilobase	JJ
670	678	sequence	sequence	NN
679	687	upstream	upstream	JJ
688	690	of	of	IN
691	694	the	the	DT
695	708	transcription	transcription	NN
709	714	start	start	NN
715	719	site	site	NN
719	720	.	.	.

721	725	This	this	DT
726	734	sequence	sequence	NN
735	743	contains	contain	VBZ
744	745	a	a	DT
746	754	promoter	promoter	NN
755	763	specific	specific	JJ
764	766	to	to	TO
767	772	cells	cell	NNS
773	775	of	of	IN
776	789	hematopoietic	hematopoietic	JJ
790	797	lineage	lineage	NN
797	798	.	.	.

799	806	However	however	RB
806	807	,	,	,
808	811	the	the	DT
812	818	tissue	tissue	NN
819	830	specificity	specificity	NN
831	833	of	of	IN
834	838	this	this	DT
839	847	promoter	promoter	NN
848	850	is	be	VBZ
851	855	only	only	RB
856	863	partial	partial	JJ
864	871	because	because	IN
872	874	it	it	PRP
875	877	is	be	VBZ
878	884	active	active	JJ
885	887	in	in	IN
888	891	all	all	DT
892	894	of	of	IN
895	898	the	the	DT
899	912	hematopoietic	hematopoietic	JJ
913	918	cells	cell	NNS
919	925	tested	test	VBN
926	930	here	here	RB
930	931	,	,	,
932	942	regardless	regardless	RB
943	945	of	of	IN
946	953	whether	whether	IN
954	958	they	they	PRP
959	973	constitutively	constitutively	RB
974	981	express	express	VBP
982	984	Fc	fc	NN
985	992	epsilon	epsilon	NN
993	996	RI-	ri-	NN
997	1002	gamma	gamma	NN
1003	1008	chain	chain	NN
1009	1020	transcripts	transcript	NNS
1020	1021	.	.	.

1022	1024	We	we	PRP
1025	1029	have	have	VBP
1030	1040	identified	identify	VBN
1041	1044	two	two	CD
1045	1053	adjacent	adjacent	JJ
1054	1064	cis-acting	cis-acting	JJ
1065	1075	regulatory	regulatory	JJ
1076	1084	elements	element	NNS
1084	1085	,	,	,
1086	1090	both	both	DT
1091	1093	of	of	IN
1094	1099	which	which	WDT
1100	1103	are	be	VBP
1104	1108	part	part	NN
1109	1111	of	of	IN
1112	1114	an	an	DT
1115	1118	Alu	Alu	NNP
1119	1125	repeat	repeat	NN
1125	1126	.	.	.

1127	1130	The	the	DT
1131	1136	first	first	JJ
1137	1138	(	(	(
1138	1147	-445/-366	-445/-366	CD
1147	1148	)	)	)
1149	1151	is	be	VBZ
1152	1153	a	a	DT
1154	1162	positive	positive	JJ
1163	1170	element	element	NN
1171	1177	active	active	JJ
1178	1180	in	in	IN
1181	1185	both	both	CC
1186	1195	basophils	basophil	NNS
1196	1199	and	and	CC
1200	1201	T	t	NN
1202	1207	cells	cell	NNS
1207	1208	.	.	.

1209	1212	The	the	DT
1213	1219	second	second	JJ
1220	1221	(	(	(
1221	1230	-365/-264	-365/-264	CD
1230	1231	)	)	)
1232	1237	binds	bind	VBZ
1238	1240	to	to	TO
1241	1248	nuclear	nuclear	JJ
1249	1256	factors	factor	NNS
1256	1257	,	,	,
1258	1263	which	which	WDT
1264	1270	appear	appear	VBP
1271	1273	to	to	TO
1274	1276	be	be	VB
1277	1286	different	different	JJ
1287	1289	in	in	IN
1290	1299	basophils	basophil	NNS
1300	1303	and	and	CC
1304	1305	T	t	NN
1306	1311	cells	cell	NNS
1311	1312	,	,	,
1313	1316	and	and	CC
1317	1321	acts	act	VBZ
1322	1324	as	as	IN
1325	1326	a	a	DT
1327	1335	negative	negative	JJ
1336	1343	element	element	NN
1344	1346	in	in	IN
1347	1356	basophils	basophil	NNS
1357	1360	and	and	CC
1361	1363	as	as	IN
1364	1365	a	a	DT
1366	1374	positive	positive	JJ
1375	1378	one	one	NN
1379	1381	in	in	IN
1382	1383	T	t	NN
1384	1389	cells	cell	NNS
1389	1390	.	.	.

1391	1395	Thus	thus	RB
1395	1396	,	,	,
1397	1401	this	this	DT
1402	1405	Alu	Alu	NNP
1406	1412	repeat	repeat	NN
1413	1414	(	(	(
1414	1416	90	90	CD
1416	1417	%	%	NN
1418	1427	identical	identical	JJ
1428	1430	to	to	TO
1431	1434	Alu	Alu	NNP
1435	1444	consensus	consensus	NN
1445	1454	sequences	sequence	NNS
1454	1455	)	)	)
1456	1459	has	have	VBZ
1460	1467	evolved	evolve	VBN
1468	1470	to	to	TO
1471	1477	become	become	VB
1478	1482	both	both	CC
1483	1484	a	a	DT
1485	1493	positive	positive	JJ
1494	1497	and	and	CC
1498	1506	negative	negative	JJ
1507	1516	regulator	regulator	NN
1516	1517	.	.	.