0	10	Regulation	regulation	NN
11	13	of	of	IN
14	17	the	the	DT
18	29	beta-globin	beta-globin	NN
30	35	locus	locus	NN
35	36	.	.	.

38	51	Transcription	transcription	NN
52	54	of	of	IN
55	58	the	the	DT
59	64	human	human	JJ
65	76	beta-globin	beta-globin	NN
77	81	gene	gene	NN
82	89	cluster	cluster	NN
90	97	depends	depend	VBZ
98	102	upon	upon	IN
103	111	upstream	upstream	JJ
112	122	regulatory	regulatory	JJ
123	132	sequences	sequence	NNS
132	133	,	,	,
134	139	which	which	WDT
140	143	are	be	VBP
144	156	collectively	collectively	RB
157	163	termed	term	VBN
164	167	the	the	DT
168	173	locus	locus	NN
174	181	control	control	NN
182	188	region	region	NN
188	189	.	.	.

190	196	Recent	recent	JJ
197	204	studies	study	NNS
205	209	have	have	VBP
210	218	provided	provide	VBN
219	222	new	new	JJ
223	231	insights	insight	NNS
232	236	into	into	IN
237	240	how	how	WRB
241	244	the	the	DT
245	255	individual	individual	JJ
256	261	genes	gene	NNS
262	264	of	of	IN
265	268	the	the	DT
269	276	cluster	cluster	NN
277	280	are	be	VBP
281	290	regulated	regulate	VBN
291	298	through	through	IN
299	310	development	development	NN
310	311	.	.	.

312	315	The	the	DT
316	320	crux	crux	NN
321	323	of	of	IN
324	339	transcriptional	transcriptional	JJ
340	350	activation	activation	NN
351	353	is	be	VBZ
354	357	how	how	WRB
358	361	the	the	DT
362	367	locus	locus	NN
368	375	control	control	NN
376	382	region	region	NN
383	395	communicates	communicate	VBZ
396	400	with	with	IN
401	404	the	the	DT
405	418	gene-proximal	gene-proximal	JJ
419	429	regulatory	regulatory	JJ
430	438	elements	element	NNS
438	439	.	.	.