0 10 Expression expression NN 11 13 of of IN 14 18 mRNA mRNA NNP 19 22 for for IN 23 26 the the DT 27 39 GATA-binding gata-binding JJ 40 48 proteins protein NNS 49 51 in in IN 52 57 human human JJ 58 69 eosinophils eosinophil NNS 70 73 and and CC 74 83 basophils basophil NNS 83 84 : : : 85 94 potential potential JJ 95 99 role role NN 100 102 in in IN 103 107 gene gene NN 108 121 transcription transcription NN 121 122 . . . 124 127 The the DT 128 138 expression expression NN 139 141 of of IN 142 145 the the DT 146 159 hematopoietic hematopoietic JJ 160 173 transcription transcription NN 174 181 factors factor NNS 182 188 GATA-1 gata-1 NN 188 189 , , , 190 196 GATA-2 gata-2 NN 196 197 , , , 198 201 and and CC 202 208 GATA-3 GATA-3 NNP 209 212 was be VBD 213 220 studied study VBN 221 223 in in IN 224 235 eosinophils eosinophil NNS 236 239 and and CC 240 249 basophils basophil NNS 249 250 . . . 251 262 Eosinophils eosinophil NNS 263 270 express express VBP 271 275 mRNA mrna NN 276 279 for for IN 280 286 GATA-1 gata-1 NN 286 287 , , , 288 294 GATA-2 gata-2 NN 294 295 , , , 296 299 and and CC 300 306 GATA-3 GATA-3 NNP 306 307 . . . 308 317 Basophils basophil NNS 318 325 express express VBP 326 332 GATA-2 gata-2 NN 333 336 and and CC 337 343 GATA-3 gata-3 NN 343 344 . . . 345 354 Treatment Treatment NNP 355 357 of of IN 358 363 HL-60 HL-60 NNP 364 376 eosinophilic eosinophilic JJ 377 385 sublines subline NNS 386 390 with with IN 391 397 either either CC 398 411 interleukin-5 interleukin-5 NN 412 414 or or CC 415 422 butyric butyric JJ 423 427 acid acid NN 428 437 increased increase VBD 438 441 the the DT 442 452 expression expression NN 453 455 of of IN 456 462 GATA-1 gata-1 NN 463 467 mRNA mrna NN 468 479 concomitant concomitant JJ 480 484 with with IN 485 488 the the DT 489 499 expression expression NN 500 502 of of IN 503 522 eosinophil-specific eosinophil-specific JJ 523 528 genes gene NNS 528 529 , , , 530 537 whereas whereas IN 538 544 levels level NNS 545 547 of of IN 548 554 GATA-2 GATA-2 NNP 555 559 mRNA mRNA NNP 560 568 remained remain VBD 569 579 relatively relatively RB 580 588 constant constant JJ 588 589 . . . 590 593 The the DT 594 602 presence presence NN 603 605 of of IN 606 610 mRNA mRNA NNP 611 614 for for IN 615 620 these these DT 621 629 proteins protein NNS 630 632 in in IN 633 644 eosinophils eosinophil NNS 645 648 and and CC 649 658 basophils basophil NNS 659 667 suggests suggest VBZ 668 672 that that IN 673 677 gene gene NN 678 691 transcription transcription NN 692 694 in in IN 695 700 these these DT 701 709 lineages lineage NNS 710 713 may may MD 714 716 be be VB 717 726 regulated regulate VBN 727 729 by by IN 730 742 GATA-binding gata-binding JJ 743 751 proteins protein NNS 751 752 . . .