0	1	A	a	DT
2	11	mammalian	mammalian	JJ
12	19	histone	histone	NN
20	31	deacetylase	deacetylase	NN
32	39	related	relate	VBN
40	42	to	to	TO
43	46	the	the	DT
47	52	yeast	yeast	NN
53	68	transcriptional	transcriptional	JJ
69	78	regulator	regulator	NN
79	84	Rpd3p	Rpd3p	NNP
85	86	[	[	(
86	89	see	see	VB
90	98	comments	comment	NNS
98	99	]	]	)
101	109	Trapoxin	Trapoxin	NNP
110	112	is	be	VBZ
113	114	a	a	DT
115	126	microbially	microbially	RB
127	134	derived	derive	VBN
135	152	cyclotetrapeptide	cyclotetrapeptide	NN
153	157	that	that	WDT
158	166	inhibits	inhibit	VBZ
167	174	histone	histone	NN
175	188	deacetylation	deacetylation	NN
189	191	in	in	FW
192	196	vivo	vivo	FW
197	200	and	and	CC
201	207	causes	cause	VBZ
208	217	mammalian	mammalian	JJ
218	223	cells	cell	NNS
224	226	to	to	TO
227	233	arrest	arrest	VB
234	236	in	in	IN
237	240	the	the	DT
241	245	cell	cell	NN
246	251	cycle	cycle	NN
251	252	.	.	.

253	254	A	a	DT
255	263	trapoxin	trapoxin	NN
264	272	affinity	affinity	NN
273	279	matrix	matrix	NN
280	283	was	be	VBD
284	288	used	use	VBN
289	291	to	to	TO
292	299	isolate	isolate	VB
300	303	two	two	CD
304	311	nuclear	nuclear	JJ
312	320	proteins	protein	NNS
321	325	that	that	WDT
326	336	copurified	copurifie	VBD
337	341	with	with	IN
342	349	histone	histone	NN
350	361	deacetylase	deacetylase	NN
362	370	activity	activity	NN
370	371	.	.	.

372	376	Both	both	DT
377	385	proteins	protein	NNS
386	390	were	be	VBD
391	401	identified	identify	VBN
402	404	by	by	IN
405	412	peptide	peptide	NN
413	428	microsequencing	microsequencing	NN
428	429	,	,	,
430	433	and	and	CC
434	435	a	a	DT
436	449	complementary	complementary	JJ
450	453	DNA	dna	NN
454	462	encoding	encode	VBG
463	466	the	the	DT
467	474	histone	histone	NN
475	486	deacetylase	deacetylase	NN
487	496	catalytic	catalytic	JJ
497	504	subunit	subunit	NN
505	506	(	(	(
506	509	HD1	HD1	NNP
509	510	)	)	)
511	514	was	be	VBD
515	521	cloned	clone	VBN
522	526	from	from	IN
527	528	a	a	DT
529	534	human	human	JJ
535	541	Jurkat	Jurkat	NNP
542	543	T	t	NN
544	548	cell	cell	NN
549	556	library	library	NN
556	557	.	.	.

558	560	As	as	IN
561	564	the	the	DT
565	574	predicted	predict	VBN
575	582	protein	protein	NN
583	585	is	be	VBZ
586	590	very	very	RB
591	598	similar	similar	JJ
599	601	to	to	TO
602	605	the	the	DT
606	611	yeast	yeast	NN
612	627	transcriptional	transcriptional	JJ
628	637	regulator	regulator	NN
638	643	Rpd3p	Rpd3p	NNP
643	644	,	,	,
645	650	these	these	DT
651	658	results	result	NNS
659	666	support	support	VBP
667	668	a	a	DT
669	673	role	role	NN
674	677	for	for	IN
678	685	histone	histone	NN
686	697	deacetylase	deacetylase	NN
698	700	as	as	IN
701	702	a	a	DT
703	706	key	key	JJ
707	716	regulator	regulator	NN
717	719	of	of	IN
720	730	eukaryotic	eukaryotic	JJ
731	744	transcription	transcription	NN
744	745	.	.	.