0 4 GATA GATA NNP 5 18 transcription transcription NN 19 26 factors factor NNS 27 36 associate associate VBP 37 41 with with IN 42 43 a a DT 44 49 novel novel JJ 50 55 class class NN 56 58 of of IN 59 66 nuclear nuclear JJ 67 73 bodies body NNS 74 76 in in IN 77 90 erythroblasts erythroblast NNS 91 94 and and CC 95 109 megakaryocytes megakaryocyte NNS 109 110 . . . 112 115 The the DT 116 123 nuclear nuclear JJ 124 136 distribution distribution NN 137 139 of of IN 140 144 GATA GATA NNP 145 158 transcription transcription NN 159 166 factors factor NNS 167 169 in in IN 170 176 murine murine JJ 177 189 haemopoietic haemopoietic JJ 190 195 cells cell NNS 196 199 was be VBD 200 208 examined examine VBN 209 211 by by IN 212 220 indirect indirect JJ 221 239 immunofluorescence immunofluorescence NN 239 240 . . . 241 249 Specific specific JJ 250 256 bright bright JJ 257 261 foci focus NNS 262 264 of of IN 265 271 GATA-1 gata-1 NN 272 284 fluorescence fluorescence NN 285 289 were be VBD 290 298 observed observe VBN 299 301 in in IN 302 318 erythroleukaemia erythroleukaemia NN 319 324 cells cell NNS 325 328 and and CC 329 336 primary primary JJ 337 343 murine murine JJ 344 357 erythroblasts erythroblast NNS 358 361 and and CC 362 376 megakaryocytes megakaryocyte NNS 376 377 , , , 378 380 in in IN 381 389 addition addition NN 390 392 to to TO 393 400 diffuse diffuse VB 401 414 nucleoplasmic nucleoplasmic JJ 415 427 localization localization NN 427 428 . . . 429 434 These these DT 435 439 foci focus NNS 439 440 , , , 441 446 which which WDT 447 451 were be VBD 452 466 preferentially preferentially RB 467 472 found find VBN 473 481 adjacent adjacent JJ 482 484 to to TO 485 493 nucleoli nucleolus NNS 494 496 or or CC 497 499 at at IN 500 503 the the DT 504 511 nuclear nuclear JJ 512 521 periphery periphery NN 521 522 , , , 523 526 did do VBD 527 530 not not RB 531 540 represent represent VB 541 546 sites site NNS 547 549 of of IN 550 556 active active JJ 557 570 transcription transcription NN 571 573 or or CC 574 581 binding binding NN 582 584 of of IN 585 591 GATA-1 gata-1 NN 592 594 to to TO 595 604 consensus consensus NN 605 610 sites site NNS 611 613 in in IN 614 617 the the DT 618 629 beta-globin beta-globin NN 630 634 loci locus NNS 634 635 . . . 636 650 Immunoelectron Immunoelectron NNP 651 661 microscopy microscopy NN 662 674 demonstrated demonstrate VBD 675 678 the the DT 679 687 presence presence NN 688 690 of of IN 691 700 intensely intensely RB 701 709 labelled label VBN 710 720 structures structure NNS 721 727 likely likely JJ 728 730 to to TO 731 740 represent represent VB 741 744 the the DT 745 751 GATA-1 gata-1 NN 752 756 foci focus NNS 757 761 seen see VBN 762 764 by by IN 765 783 immunofluorescence immunofluorescence NN 783 784 . . . 785 788 The the DT 789 795 GATA-1 gata-1 NN 796 803 nuclear nuclear JJ 804 810 bodies body NNS 811 819 differed differ VBD 820 824 from from IN 825 835 previously previously RB 836 845 described describe VBN 846 853 nuclear nuclear JJ 854 864 structures structure NNS 865 868 and and CC 869 874 there there EX 875 878 was be VBD 879 881 no no DT 882 897 co-localization co-localization NN 898 902 with with IN 903 910 nuclear nuclear JJ 911 919 antigens antigen NNS 920 928 involved involve VBN 929 931 in in IN 932 935 RNA RNA NNP 936 946 processing processing NN 947 949 or or CC 950 955 other other JJ 956 966 ubiquitous ubiquitous JJ 967 968 ( ( ( 968 971 Spl Spl NNP 971 972 , , , 973 978 c-Jun c-jun NN 979 982 and and CC 983 986 TBP TBP NNP 986 987 ) ) ) 988 990 or or CC 991 1003 haemopoietic haemopoietic JJ 1004 1005 ( ( ( 1005 1010 NF-E2 nf-e2 NN 1010 1011 ) ) ) 1012 1025 transcription transcription NN 1026 1033 factors factor NNS 1033 1034 . . . 1035 1048 Interestingly interestingly RB 1048 1049 , , , 1050 1056 GATA-2 gata-2 NN 1057 1060 and and CC 1061 1067 GATA-3 gata-3 NN 1068 1076 proteins protein NNS 1077 1081 also also RB 1082 1091 localized localize VBD 1092 1094 to to TO 1095 1098 the the DT 1099 1103 same same JJ 1104 1111 nuclear nuclear JJ 1112 1118 bodies body NNS 1119 1121 in in IN 1122 1126 cell cell NN 1127 1132 lines line NNS 1133 1146 co-expressing co-expresse VBG 1147 1153 GATA-1 gata-1 NN 1154 1157 and and CC 1158 1160 -2 -2 CD 1161 1163 or or CC 1164 1170 GATA-1 gata-1 NN 1171 1174 and and CC 1175 1177 -3 -3 CD 1178 1182 gene gene NN 1183 1191 products product NNS 1191 1192 . . . 1193 1197 This this DT 1198 1205 pattern pattern NN 1206 1208 of of IN 1209 1221 distribution distribution NN 1222 1224 is be VBZ 1224 1225 , , , 1226 1230 thus thus RB 1231 1234 far far RB 1234 1235 , , , 1236 1242 unique unique JJ 1243 1245 to to TO 1246 1249 the the DT 1250 1254 GATA GATA NNP 1255 1268 transcription transcription NN 1269 1276 factors factor NNS 1277 1280 and and CC 1281 1289 suggests suggest VBZ 1290 1291 a a DT 1292 1307 protein-protein protein-protein JJ 1308 1319 interaction interaction NN 1320 1324 with with IN 1325 1330 other other JJ 1331 1341 components component NNS 1342 1344 of of IN 1345 1348 the the DT 1349 1356 nuclear nuclear JJ 1357 1363 bodies body NNS 1364 1367 via via IN 1368 1371 the the DT 1372 1376 GATA GATA NNP 1377 1381 zinc zinc NN 1382 1388 finger finger NN 1389 1395 domain domain NN 1395 1396 . . .