0 11 Involvement involvement NN 12 14 of of IN 15 28 intracellular intracellular JJ 29 33 Ca2+ ca2+ NN 34 36 in in IN 37 52 oxidant-induced oxidant-induced JJ 53 61 NF-kappa NF-kappa NNP 62 63 B B NNP 64 74 activation activation NN 74 75 . . . 77 79 In in IN 80 85 human human JJ 86 92 Jurkat Jurkat NNP 93 94 T t NN 95 100 cells cell NNS 101 104 and and CC 105 108 its its PRP$ 109 117 subclone subclone NN 118 126 Wurzburg Wurzburg NNP 127 132 cells cell NNS 133 140 oxidant oxidant NN 141 150 challenge challenge NN 151 159 elevated elevate VBN 160 161 [ [ ( 161 167 Ca2+]i Ca2+]i NNP 168 170 by by IN 171 181 mobilizing mobilize VBG 182 186 Ca2+ ca2+ NN 187 191 from from IN 192 205 intracellular intracellular JJ 206 212 stores store NNS 212 213 . . . 214 216 In in IN 217 223 Jurkat Jurkat NNP 224 229 cells cell NNS 230 234 this this DT 235 241 effect effect NN 242 245 was be VBD 246 251 rapid rapid JJ 252 255 and and CC 256 265 transient transient JJ 265 266 , , , 267 270 but but CC 271 273 in in IN 274 282 Wurzburg Wurzburg NNP 283 288 cells cell NNS 289 292 the the DT 293 301 response response NN 302 305 was be VBD 306 310 slow slow JJ 311 314 and and CC 315 324 sustained sustained JJ 324 325 . . . 326 338 H2O2-induced h2o2-induced JJ 339 348 NF-kappaB NF-kappaB NNP 349 359 activation activation NN 360 362 in in IN 363 371 Wurzburg Wurzburg NNP 372 377 cells cell NNS 378 381 was be VBD 382 385 not not RB 386 396 influenced influence VBN 397 399 by by IN 400 403 the the DT 404 412 presence presence NN 413 415 of of IN 416 429 extracellular extracellular JJ 430 434 EGTA EGTA NNP 435 438 but but CC 439 442 was be VBD 443 450 totally totally RB 451 460 inhibited inhibit VBN 461 463 in in IN 464 469 cells cell NNS 470 474 that that WDT 475 479 were be VBD 480 486 loaded load VBN 487 491 with with IN 492 502 esterified esterify VBN 503 507 EGTA EGTA NNP 507 508 . . . 509 511 In in IN 512 518 Jurkat Jurkat NNP 519 524 cells cell NNS 525 529 that that WDT 530 533 are be VBP 534 537 not not RB 538 547 sensitive sensitive JJ 548 550 to to TO 551 563 H2O2-induced h2o2-induced JJ 564 573 NF-kappaB NF-kappaB NNP 574 584 activation activation NN 584 585 , , , 586 590 H2O2 h2o2 NN 591 602 potentiated potentiate VBD 603 612 NF-kappaB nf-kappab NN 613 623 activation activation NN 624 626 in in IN 627 630 the the DT 631 639 presence presence NN 640 642 of of IN 643 652 sustained sustained JJ 653 657 high high JJ 658 659 [ [ ( 659 665 Ca2+]i Ca2+]i NNP 666 675 following follow VBG 676 688 thapsigargin thapsigargin NN 689 698 treatment treatment NN 698 699 . . . 700 709 NF-kappaB NF-kappaB NNP 710 720 regulatory regulatory JJ 721 727 effect effect NN 728 730 of of IN 731 744 alpha-lipoate alpha-lipoate NN 745 748 and and CC 749 765 N-acetylcysteine N-acetylcysteine NNP 766 774 appeared appear VBD 775 777 to to TO 778 780 be be VB 780 781 , , , 782 784 at at IN 785 790 least least JJS 791 793 in in IN 794 798 part part NN 798 799 , , , 800 803 due due IN 804 806 to to TO 807 812 their their PRP$ 813 820 ability ability NN 821 823 to to TO 824 833 stabilize stabilize VB 834 843 elevation elevation NN 844 846 of of IN 847 848 [ [ ( 848 854 Ca2+]i Ca2+]i NNP 855 864 following follow VBG 865 872 oxidant oxidant JJ 873 882 challenge challenge NN 882 883 . . . 884 891 Results result NNS 892 894 of of IN 895 899 this this DT 900 905 study study NN 906 914 indicate indicate VBP 915 919 that that IN 920 921 a a DT 922 931 sustained sustain VBN 932 940 elevated elevate VBN 941 942 [ [ ( 942 948 Ca2+]i Ca2+]i NNP 949 951 is be VBZ 952 953 a a DT 954 965 significant significant JJ 966 972 factor factor NN 973 975 in in IN 976 991 oxidant-induced oxidant-induced JJ 992 1001 NF-kappaB NF-kappaB NNP 1002 1012 activation activation NN 1012 1013 . . .