0 13 Transcription transcription NN 14 21 factors factor NNS 22 24 of of IN 25 26 T t NN 27 30 and and CC 31 32 B B NNP 33 51 lymphocytes–basic lymphocytes–basic JJ 52 60 research research NN 61 64 and and CC 65 73 clinical clinical JJ 74 86 perspectives perspective NNS 87 90 for for IN 91 107 gastroenterology gastroenterology NN 107 108 . . . 110 116 Tissue tissue NN 117 125 specific specific JJ 126 136 regulation regulation NN 137 139 of of IN 140 144 gene gene NN 145 155 expression expression NN 156 158 by by IN 159 172 transcription transcription NN 173 180 factors factor NNS 181 183 is be VBZ 184 185 a a DT 186 197 fascinating fascinating JJ 198 201 new new JJ 202 207 field field NN 208 210 in in IN 211 220 molecular molecular JJ 221 231 immunology immunology NN 231 232 . . . 233 237 This this DT 238 244 review review NN 245 255 summarizes summarize VBZ 256 260 data datum NNS 261 263 on on IN 264 272 specific specific JJ 273 283 regulation regulation NN 284 286 of of IN 287 296 promoters promoter NNS 297 300 and and CC 301 310 enhancers enhancer NNS 311 313 by by IN 314 321 nuclear nuclear JJ 322 334 trans-acting trans-acting JJ 335 342 factors factor NNS 343 345 in in IN 346 357 lymphocytes lymphocyte NNS 357 358 . . . 359 362 The the DT 363 373 structural structural JJ 374 381 classes class NNS 382 384 of of IN 385 398 transcription transcription NN 399 406 factors factor NNS 407 410 are be VBP 411 420 described describe VBN 421 424 and and CC 425 430 basic basic JJ 431 438 methods method NNS 439 442 for for IN 443 452 detection detection NN 453 456 and and CC 457 465 analysis analysis NN 466 468 of of IN 469 482 transcription transcription NN 483 490 factors factor NNS 491 494 are be VBP 495 503 detailed detail VBN 503 504 . . . 505 516 Furthermore furthermore RB 516 517 , , , 518 521 the the DT 522 526 most most RBS 527 536 important important JJ 537 549 trans-acting trans-acting JJ 550 557 factors factor NNS 558 560 of of IN 561 562 T t NN 563 566 and and CC 567 568 B B NNP 569 580 lymphocytes lymphocyte NNS 581 582 ( ( ( 582 586 e.g. e.g. FW 587 592 NF-kB NF-kB NNP 592 593 , , , 594 599 NF-AT NF-AT NNP 600 603 and and CC 604 608 STAT STAT NNP 609 617 families family NNS 617 618 ) ) ) 619 622 and and CC 623 628 their their PRP$ 629 639 functional functional JJ 640 650 importance importance NN 651 654 are be VBP 655 664 described describe VBN 664 665 . . . 666 673 Several several JJ 674 681 methods method NNS 682 685 for for IN 686 694 specific specific JJ 695 710 down-regulation down-regulation NN 711 713 of of IN 714 727 transcription transcription NN 728 735 factors factor NNS 736 739 are be VBP 740 745 shown show VBN 746 750 that that IN 751 754 may may MD 755 757 be be VB 758 766 relevant relevant JJ 767 769 to to TO 770 779 treatment treatment NN 780 782 of of IN 783 788 human human JJ 789 796 disease disease NN 796 797 . . . 798 801 The the DT 802 806 data datum NNS 807 810 are be VBP 811 820 discussed discuss VBN 821 825 with with IN 826 832 regard regard NN 833 835 to to TO 836 841 their their PRP$ 842 851 potential potential JJ 852 860 clinical clinical JJ 861 870 relevance relevance NN 871 874 for for IN 875 891 gastroenterology gastroenterology NN 891 892 . . .