0	3	The	the	DT
4	8	role	role	NN
9	11	of	of	IN
12	16	BSAP	BSAP	NNP
17	18	(	(	(
18	23	Pax-5	Pax-5	NNP
23	24	)	)	)
25	27	in	in	IN
28	34	B-cell	b-cell	NN
35	46	development	development	NN
46	47	.	.	.

49	52	The	the	DT
53	62	hierarchy	hierarchy	NN
63	65	of	of	IN
66	81	transcriptional	transcriptional	JJ
82	89	control	control	NN
90	92	in	in	IN
93	99	B-cell	b-cell	NN
100	111	development	development	NN
112	115	has	have	VBZ
116	124	recently	recently	RB
125	129	been	be	VBN
130	138	analyzed	analyze	VBN
139	141	by	by	IN
142	150	targeted	target	VBN
151	155	gene	gene	NN
156	168	inactivation	inactivation	NN
169	171	in	in	IN
172	175	the	the	DT
176	181	mouse	mouse	NN
181	182	.	.	.

183	185	In	in	IN
186	190	this	this	DT
191	197	manner	manner	NN
197	198	,	,	,
199	202	the	the	DT
203	209	paired	paired	JJ
210	213	box	box	NN
214	224	containing	contain	VBG
225	229	gene	gene	NN
230	235	Pax-5	pax-5	NN
235	236	,	,	,
237	245	encoding	encode	VBG
246	249	the	the	DT
250	251	B	B	NNP
252	256	cell	cell	NN
257	265	specific	specific	JJ
266	279	transcription	transcription	NN
280	286	factor	factor	NN
287	291	BSAP	BSAP	NNP
291	292	,	,	,
293	296	has	have	VBZ
297	301	been	be	VBN
302	307	shown	show	VBN
308	310	to	to	TO
311	315	play	play	VB
316	317	a	a	DT
318	321	key	key	JJ
322	326	role	role	NN
327	329	in	in	IN
330	335	early	early	JJ
336	337	B	B	NNP
338	351	lymphopoiesis	lymphopoiesis	NN
351	352	.	.	.

353	358	Other	other	JJ
359	371	experimental	experimental	JJ
372	382	strategies	strategy	NNS
383	387	have	have	VBP
388	398	implicated	implicate	VBN
399	403	BSAP	bsap	NN
404	406	in	in	IN
407	410	the	the	DT
411	418	control	control	NN
419	421	of	of	IN
422	426	cell	cell	NN
427	440	proliferation	proliferation	NN
440	441	,	,	,
442	449	isotype	isotype	NN
450	459	switching	switching	NN
460	463	and	and	CC
464	477	transcription	transcription	NN
478	480	of	of	IN
481	484	the	the	DT
485	499	immunoglobulin	immunoglobulin	NN
500	511	heavy-chain	heavy-chain	JJ
512	516	gene	gene	NN
517	519	at	at	IN
520	524	late	late	JJ
525	531	stages	stage	NNS
532	534	of	of	IN
535	541	B-cell	b-cell	NN
542	557	differentiation	differentiation	NN
557	558	.	.	.