0	9	Induction	Induction	NNP
10	12	of	of	IN
13	18	CIITA	CIITA	NNP
19	22	and	and	CC
23	35	modification	modification	NN
36	38	of	of	IN
39	41	in	in	FW
42	46	vivo	vivo	FW
47	53	HLA-DR	HLA-DR	NNP
54	62	promoter	promoter	NN
63	72	occupancy	occupancy	NN
73	75	in	in	IN
76	82	normal	normal	JJ
83	89	thymic	thymic	JJ
90	100	epithelial	epithelial	JJ
101	106	cells	cell	NNS
107	114	treated	treat	VBN
115	119	with	with	IN
120	129	IFN-gamma	IFN-gamma	NNP
129	130	:	:	:
131	143	similarities	similarity	NNS
144	147	and	and	CC
148	160	distinctions	distinction	NNS
161	165	with	with	IN
166	173	respect	respect	NN
174	176	to	to	TO
177	196	HLA-DR-constitutive	hla-dr-constitutive	JJ
197	198	B	B	NNP
199	204	cells	cell	NNS
204	205	.	.	.

207	209	In	in	IN
210	214	this	this	DT
215	220	study	study	NN
220	221	,	,	,
222	225	the	the	DT
226	235	IFN-gamma	IFN-gamma	NNP
236	245	induction	induction	NN
246	248	of	of	IN
249	252	MHC	MHC	NNP
253	258	class	class	NN
259	261	II	ii	CD
262	266	gene	gene	NN
267	277	expression	expression	NN
278	280	in	in	IN
281	288	primary	primary	JJ
289	297	cultures	culture	NNS
298	300	of	of	IN
301	307	thymic	thymic	JJ
308	318	epithelial	epithelial	JJ
319	324	cells	cell	NNS
325	326	(	(	(
326	329	TEC	TEC	NNP
329	330	)	)	)
331	334	was	be	VBD
335	343	analyzed	analyze	VBN
343	344	.	.	.

345	349	This	this	DT
350	358	cellular	cellular	JJ
359	365	system	system	NN
366	372	offers	offer	VBZ
373	376	the	the	DT
377	386	advantage	advantage	NN
387	391	that	that	IN
392	395	MHC	MHC	NNP
396	401	class	class	NN
402	404	II	ii	CD
405	414	induction	induction	NN
415	417	is	be	VBZ
418	425	studied	study	VBN
426	428	in	in	IN
429	430	a	a	DT
431	432	“	``	``
432	443	physiologic	physiologic	JJ
443	444	”	''	''
445	449	cell	cell	NN
450	457	lineage	lineage	NN
458	462	that	that	IN
462	463	,	,	,
464	466	as	as	IN
467	468	a	a	DT
469	475	result	result	NN
476	478	of	of	IN
479	483	this	this	DT
484	494	expression	expression	NN
495	501	within	within	IN
502	505	the	the	DT
506	512	thymus	thymus	NN
512	513	,	,	,
514	516	is	be	VBZ
517	524	thought	think	VBN
525	527	to	to	TO
528	539	participate	participate	VB
540	542	to	to	TO
543	546	the	the	DT
547	556	selection	selection	NN
557	560	and	and	CC
561	571	maturation	maturation	NN
572	574	of	of	IN
575	578	the	the	DT
579	580	T	t	NN
581	586	cells	cell	NNS
586	587	.	.	.

588	590	It	it	PRP
591	594	was	be	VBD
595	600	found	find	VBN
601	605	that	that	IN
606	609	the	the	DT
610	613	MHC	MHC	NNP
614	619	class	class	NN
620	622	II	ii	CD
623	627	gene	gene	NN
628	638	expression	expression	NN
639	642	was	be	VBD
643	653	associated	associate	VBN
654	658	with	with	IN
659	662	the	the	DT
663	665	de	de	FW
666	670	novo	novo	FW
671	684	transcription	transcription	NN
685	687	of	of	IN
688	691	the	the	DT
692	696	gene	gene	NN
697	705	encoding	encode	VBG
706	709	the	the	DT
710	715	CIITA	CIITA	NNP
716	731	trans-activator	trans-activator	NN
731	732	,	,	,
733	734	a	a	DT
735	742	crucial	crucial	JJ
743	746	MHC	MHC	NNP
747	752	class	class	NN
753	755	II	ii	CD
756	760	gene	gene	NN
761	771	regulatory	regulatory	JJ
772	778	factor	factor	NN
778	779	.	.	.

780	791	Furthermore	furthermore	RB
791	792	,	,	,
793	796	the	the	DT
797	804	anatomy	anatomy	NN
805	807	of	of	IN
808	819	interaction	interaction	NN
820	827	between	between	IN
828	831	the	the	DT
832	835	MHC	MHC	NNP
836	841	class	class	NN
842	844	II	ii	CD
845	848	DRA	DRA	NNP
849	857	promoter	promoter	NN
858	861	and	and	CC
862	875	corresponding	corresponding	JJ
876	883	binding	binding	NN
884	891	factors	factor	NNS
892	895	was	be	VBD
896	904	analyzed	analyze	VBN
905	907	by	by	IN
908	910	in	in	FW
911	915	vivo	vivo	FW
916	921	DNAse	DNAse	NNP
922	923	I	i	NN
924	933	footprint	footprint	NN
933	934	.	.	.

935	937	It	it	PRP
938	941	was	be	VBD
942	947	found	find	VBN
948	952	that	that	IN
953	962	treatment	treatment	NN
963	967	with	with	IN
968	977	IFN-gamma	IFN-gamma	NNP
978	985	induces	induce	VBZ
986	993	changes	change	NNS
994	996	in	in	IN
997	1000	the	the	DT
1001	1010	occupancy	occupancy	NN
1011	1013	of	of	IN
1014	1017	the	the	DT
1018	1021	DRA	DRA	NNP
1022	1026	gene	gene	NN
1027	1037	regulatory	regulatory	JJ
1038	1047	sequences	sequence	NNS
1048	1050	by	by	IN
1051	1058	nuclear	nuclear	JJ
1059	1066	factors	factor	NNS
1066	1067	.	.	.

1068	1071	The	the	DT
1072	1081	resulting	result	VBG
1082	1091	occupancy	occupancy	NN
1092	1100	displays	display	VBZ
1101	1107	strong	strong	JJ
1108	1120	similarities	similarity	NNS
1121	1125	with	with	IN
1126	1129	the	the	DT
1130	1133	one	one	CD
1134	1142	observed	observe	VBN
1143	1145	in	in	IN
1146	1149	the	the	DT
1150	1153	MHC	MHC	NNP
1154	1159	class	class	NN
1160	1175	II-constitutive	ii-constitutive	JJ
1176	1177	B	B	NNP
1178	1183	cells	cell	NNS
1183	1184	,	,	,
1185	1196	represented	represent	VBN
1197	1199	by	by	IN
1200	1204	both	both	CC
1205	1208	the	the	DT
1209	1216	Burkitt	Burkitt	NNP
1217	1225	lymphoma	lymphoma	NN
1226	1230	line	line	NN
1231	1235	Raji	Raji	NNP
1236	1239	and	and	CC
1240	1246	normal	normal	JJ
1247	1254	tonsil-	tonsil-	NN
1255	1262	derived	derive	VBN
1263	1264	B	B	NNP
1265	1270	cells	cell	NNS
1270	1271	.	.	.

1272	1279	However	however	RB
1279	1280	,	,	,
1281	1285	some	some	DT
1286	1294	peculiar	peculiar	JJ
1295	1306	differences	difference	NNS
1307	1311	were	be	VBD
1312	1320	observed	observe	VBN
1321	1328	between	between	IN
1329	1332	the	the	DT
1333	1336	TEC	TEC	NNP
1336	1337	,	,	,
1338	1344	either	either	CC
1345	1362	IFN-gamma-induced	ifn-gamma-induced	JJ
1363	1365	or	or	CC
1366	1369	not	not	RB
1369	1370	,	,	,
1371	1374	and	and	CC
1375	1378	the	the	DT
1379	1391	constitutive	constitutive	JJ
1392	1393	B	B	NNP
1394	1399	cells	cell	NNS
1399	1400	.	.	.

1401	1406	These	these	DT
1407	1414	results	result	NNS
1415	1422	suggest	suggest	VBP
1423	1427	that	that	IN
1428	1432	both	both	CC
1433	1439	common	common	JJ
1440	1450	mechanisms	mechanism	NNS
1450	1451	,	,	,
1452	1456	such	such	JJ
1457	1459	as	as	IN
1460	1463	the	the	DT
1464	1467	one	one	CD
1468	1476	mediated	mediate	VBN
1477	1479	by	by	IN
1480	1483	the	the	DT
1484	1489	CIITA	CIITA	NNP
1490	1505	trans-activator	trans-activator	NN
1505	1506	,	,	,
1507	1510	and	and	CC
1511	1519	distinct	distinct	JJ
1520	1535	tissue-specific	tissue-specific	JJ
1536	1547	constraints	constraint	NNS
1548	1558	contribute	contribute	VBP
1559	1561	to	to	TO
1562	1565	the	the	DT
1566	1581	transcriptional	transcriptional	JJ
1582	1589	control	control	NN
1590	1592	of	of	IN
1593	1605	constitutive	constitutive	JJ
1606	1609	and	and	CC
1610	1627	IFN-gamma-induced	ifn-gamma-induced	JJ
1628	1631	MHC	MHC	NNP
1632	1637	class	class	NN
1638	1640	II	ii	CD
1641	1645	gene	gene	NN
1646	1656	expression	expression	NN
1656	1657	.	.	.