0	4	oriP	oriP	NNP
5	7	is	be	VBZ
8	17	essential	essential	JJ
18	21	for	for	IN
22	26	EBNA	EBNA	NNP
27	31	gene	gene	NN
32	40	promoter	promoter	NN
41	49	activity	activity	NN
50	52	in	in	IN
53	65	Epstein-Barr	epstein-barr	JJ
66	84	virus-immortalized	virus-immortalized	JJ
85	99	lymphoblastoid	lymphoblastoid	JJ
100	104	cell	cell	NN
105	110	lines	line	NNS
110	111	.	.	.

113	119	During	during	IN
120	132	Epstein-Barr	epstein-barr	JJ
133	138	virus	virus	NN
139	145	latent	latent	JJ
146	155	infection	infection	NN
156	158	of	of	IN
159	160	B	B	NNP
161	172	lymphocytes	lymphocyte	NNS
173	175	in	in	FW
176	181	vitro	vitro	FW
181	182	,	,	,
183	186	six	six	CD
187	192	viral	viral	JJ
193	200	nuclear	nuclear	JJ
201	209	antigens	antigen	NNS
210	211	(	(	(
211	216	EBNAs	EBNA	NNPS
216	217	)	)	)
218	221	are	be	VBP
222	231	expressed	express	VBN
232	236	from	from	IN
237	240	one	one	CD
241	243	of	of	IN
244	247	two	two	CD
248	257	promoters	promoter	NNS
257	258	,	,	,
259	261	Cp	Cp	NNP
262	264	or	or	CC
265	267	Wp	Wp	NNP
267	268	,	,	,
269	274	whose	whose	WP$
275	285	activities	activity	NNS
286	289	are	be	VBP
290	298	mutually	mutually	RB
299	308	exclusive	exclusive	JJ
308	309	.	.	.

310	314	Upon	upon	IN
315	324	infection	infection	NN
324	325	,	,	,
326	328	Wp	Wp	NNP
329	331	is	be	VBZ
332	341	initially	initially	RB
342	348	active	active	JJ
348	349	,	,	,
350	358	followed	follow	VBN
359	361	by	by	IN
362	363	a	a	DT
364	370	switch	switch	NN
371	373	to	to	TO
374	376	Cp	cp	NN
377	380	for	for	IN
381	384	the	the	DT
385	393	duration	duration	NN
394	396	of	of	IN
397	404	latency	latency	NN
404	405	.	.	.

406	408	In	in	IN
409	413	this	this	DT
414	419	study	study	NN
419	420	,	,	,
421	424	the	the	DT
425	431	region	region	NN
432	440	upstream	upstream	JJ
441	443	of	of	IN
444	446	Cp	Cp	NNP
447	450	was	be	VBD
451	459	analyzed	analyze	VBN
460	463	for	for	IN
464	467	the	the	DT
468	476	presence	presence	NN
477	479	of	of	IN
480	483	cis	cis	NN
484	492	elements	element	NNS
493	501	involved	involve	VBN
502	504	in	in	IN
505	515	regulating	regulate	VBG
516	519	the	the	DT
520	530	activities	activity	NNS
531	533	of	of	IN
534	537	the	the	DT
538	542	EBNA	EBNA	NNP
543	547	gene	gene	NN
548	557	promoters	promoter	NNS
558	560	in	in	IN
561	572	established	establish	VBN
573	575	in	in	FW
576	581	vitro	vitro	FW
582	594	immortalized	immortalize	VBN
595	609	lymphoblastoid	lymphoblastoid	JJ
610	614	cell	cell	NN
615	620	lines	line	NNS
621	622	(	(	(
622	626	LCLs	LCL	NNP
626	627	)	)	)
627	628	.	.	.

629	631	It	it	PRP
632	635	was	be	VBD
636	646	determined	determine	VBN
647	651	that	that	IN
652	656	oriP	oriP	NNP
656	657	,	,	,
658	661	the	the	DT
662	668	origin	origin	NN
669	672	for	for	IN
673	681	episomal	episomal	JJ
682	693	maintenance	maintenance	NN
694	700	during	during	IN
701	708	latency	latency	NN
708	709	,	,	,
710	712	is	be	VBZ
713	722	essential	essential	JJ
723	726	for	for	IN
727	736	efficient	efficient	JJ
737	750	transcription	transcription	NN
751	761	initiation	initiation	NN
762	766	from	from	IN
767	773	either	either	CC
774	776	Cp	Cp	NNP
777	779	or	or	CC
780	782	Wp	Wp	NNP
783	785	in	in	IN
786	790	LCLs	LCL	NNP
790	791	,	,	,
792	794	as	as	RB
795	799	well	well	RB
800	802	as	as	IN
803	805	in	in	IN
806	810	some	some	DT
811	818	Burkitt	Burkitt	NNP
818	820	’s	's	POS
821	829	lymphoma	lymphoma	NN
830	834	cell	cell	NN
835	840	lines	line	NNS
840	841	.	.	.

842	850	Deletion	deletion	NN
851	853	of	of	IN
854	857	the	the	DT
858	873	EBNA2-dependent	ebna2-dependent	JJ
874	882	enhancer	enhancer	NN
883	890	located	located	JJ
891	899	upstream	upstream	RB
900	902	of	of	IN
903	905	Cp	Cp	NNP
906	914	resulted	result	VBD
915	917	in	in	IN
918	919	a	a	DT
920	923	ca.	ca.	FW
924	928	two-	two-	CD
929	931	to	to	TO
932	940	fivefold	fivefold	JJ
941	950	reduction	reduction	NN
951	953	in	in	IN
954	956	Cp	Cp	NNP
957	965	activity	activity	NN
966	968	in	in	IN
969	972	the	the	DT
973	977	LCLs	LCL	NNP
978	985	assayed	assay	VBN
985	986	.	.	.

987	991	More	more	RBR
992	1001	extensive	extensive	JJ
1002	1010	deletion	deletion	NN
1011	1013	of	of	IN
1014	1023	sequences	sequence	NNS
1024	1032	upstream	upstream	JJ
1033	1035	of	of	IN
1036	1038	Cp	Cp	NNP
1038	1039	,	,	,
1040	1049	including	include	VBG
1050	1053	the	the	DT
1054	1069	EBNA2-dependent	ebna2-dependent	JJ
1070	1078	enhancer	enhancer	NN
1078	1079	,	,	,
1080	1088	resulted	result	VBD
1089	1091	in	in	IN
1092	1098	nearly	nearly	RB
1099	1107	complete	complete	JJ
1108	1112	loss	loss	NN
1113	1115	of	of	IN
1116	1118	Cp	Cp	NNP
1119	1127	activity	activity	NN
1127	1128	.	.	.

1129	1133	This	this	DT
1134	1138	loss	loss	NN
1139	1141	of	of	IN
1142	1150	activity	activity	NN
1151	1154	was	be	VBD
1155	1160	shown	show	VBN
1161	1163	to	to	TO
1164	1173	correlate	correlate	VB
1174	1178	with	with	IN
1179	1187	deletion	deletion	NN
1188	1190	of	of	IN
1191	1194	two	two	CD
1195	1200	CCAAT	CCAAT	NNP
1201	1206	boxes	box	NNS
1206	1207	,	,	,
1208	1209	a	a	DT
1210	1218	proximal	proximal	JJ
1219	1224	CCAAT	ccaat	NN
1225	1228	box	box	NN
1229	1236	located	located	JJ
1237	1239	at	at	IN
1240	1242	bp	bp	NN
1243	1246	-61	-61	CD
1247	1249	to	to	TO
1250	1253	-65	-65	CD
1254	1257	and	and	CC
1258	1259	a	a	DT
1260	1266	distal	distal	JJ
1267	1272	CCAAT	ccaat	NN
1273	1276	box	box	NN
1277	1284	located	located	JJ
1285	1287	at	at	IN
1288	1290	bp	bp	NN
1291	1295	-253	-253	CD
1296	1298	to	to	TO
1299	1303	-257	-257	CD
1303	1304	,	,	,
1305	1313	upstream	upstream	RB
1314	1316	of	of	IN
1317	1319	Cp	Cp	NNP
1319	1320	.	.	.

1321	1334	Site-directed	site-directed	JJ
1335	1346	mutagenesis	mutagenesis	NN
1347	1349	of	of	IN
1350	1355	these	these	DT
1356	1359	cis	cis	NN
1360	1368	elements	element	NNS
1369	1381	demonstrated	demonstrate	VBD
1382	1386	that	that	IN
1387	1389	Cp	Cp	NNP
1390	1398	activity	activity	NN
1399	1401	is	be	VBZ
1402	1408	highly	highly	RB
1409	1418	dependent	dependent	JJ
1419	1421	on	on	IN
1422	1425	the	the	DT
1426	1434	presence	presence	NN
1435	1437	of	of	IN
1438	1439	a	a	DT
1440	1448	properly	properly	RB
1449	1459	positioned	position	VBN
1460	1465	CCAAT	CCAAT	NNP
1466	1469	box	box	NN
1469	1470	,	,	,
1471	1475	with	with	IN
1476	1479	the	the	DT
1480	1490	dependence	dependence	NN
1491	1493	on	on	IN
1494	1497	the	the	DT
1498	1504	distal	distal	JJ
1505	1510	CCAAT	ccaat	NN
1511	1514	box	box	NN
1515	1523	apparent	apparent	JJ
1524	1528	only	only	RB
1529	1533	when	when	WRB
1534	1537	the	the	DT
1538	1546	proximal	proximal	JJ
1547	1552	CCAAT	CCAAT	NNP
1553	1556	box	box	NN
1557	1560	was	be	VBD
1561	1568	deleted	delete	VBN
1569	1571	or	or	CC
1572	1579	mutated	mutate	VBN
1579	1580	.	.	.

1581	1589	Deletion	deletion	NN
1590	1592	of	of	IN
1593	1596	the	the	DT
1597	1611	glucocorticoid	glucocorticoid	NN
1612	1620	response	response	NN
1621	1629	elements	element	NNS
1630	1637	located	located	JJ
1638	1640	at	at	IN
1641	1644	ca.	ca.	FW
1645	1647	bp	bp	NN
1648	1652	-850	-850	CD
1653	1661	upstream	upstream	RB
1662	1664	of	of	IN
1665	1667	Cp	Cp	NNP
1668	1671	did	do	VBD
1672	1675	not	not	RB
1676	1682	result	result	VB
1683	1685	in	in	IN
1686	1687	a	a	DT
1688	1699	significant	significant	JJ
1700	1704	loss	loss	NN
1705	1707	in	in	IN
1708	1716	activity	activity	NN
1716	1717	.	.	.

1718	1720	In	in	IN
1721	1728	general	general	JJ
1728	1729	,	,	,
1730	1739	deletions	deletion	NNS
1740	1745	which	which	WDT
1746	1756	diminished	diminish	VBD
1757	1759	Cp	Cp	NNP
1760	1768	activity	activity	NN
1769	1777	resulted	result	VBD
1778	1780	in	in	IN
1781	1790	induction	induction	NN
1791	1793	of	of	IN
1794	1796	Wp	Wp	NNP
1797	1805	activity	activity	NN
1805	1806	,	,	,
1807	1817	consistent	consistent	JJ
1818	1822	with	with	IN
1823	1834	suppression	suppression	NN
1835	1837	of	of	IN
1838	1840	Wp	Wp	NNP
1841	1849	activity	activity	NN
1850	1852	by	by	IN
1853	1868	transcriptional	transcriptional	JJ
1869	1881	interference	interference	NN
1882	1886	from	from	IN
1887	1889	Cp	Cp	NNP
1889	1890	.	.	.

1891	1894	The	the	DT
1895	1909	identification	identification	NN
1910	1912	of	of	IN
1913	1917	oriP	oriP	NNP
1918	1921	and	and	CC
1922	1925	the	the	DT
1926	1941	EBNA2-dependent	ebna2-dependent	JJ
1942	1950	enhancer	enhancer	NN
1951	1953	as	as	IN
1954	1957	the	the	DT
1958	1963	major	major	JJ
1964	1972	positive	positive	JJ
1973	1976	cis	cis	NN
1977	1985	elements	element	NNS
1986	1994	involved	involve	VBN
1995	1997	in	in	IN
1998	2008	regulating	regulate	VBG
2009	2011	Cp	cp	NN
2012	2020	activity	activity	NN
2021	2023	in	in	IN
2024	2027	LCL	LCL	NNP
2028	2036	suggests	suggest	VBZ
2037	2041	that	that	IN
2042	2046	EBNA	EBNA	NNP
2047	2051	gene	gene	NN
2052	2065	transcription	transcription	NN
2066	2068	is	be	VBZ
2069	2076	largely	largely	RB
2077	2090	autoregulated	autoregulate	VBN
2091	2093	by	by	IN
2094	2098	EBNA	EBNA	NNP
2099	2100	1	1	CD
2101	2104	and	and	CC
2105	2109	EBNA	EBNA	NNP
2110	2111	2	2	CD
2111	2112	.	.	.