0 10 Regulation regulation NN 11 13 of of IN 14 18 gene gene NN 19 29 expression expression NN 30 32 at at IN 33 38 early early JJ 39 45 stages stage NNS 46 48 of of IN 49 55 B-cell B-cell NNP 56 59 and and CC 60 66 T-cell t-cell NN 67 82 differentiation differentiation NN 82 83 . . . 85 88 The the DT 89 99 expression expression NN 100 102 of of IN 103 111 distinct distinct JJ 112 116 sets set NNS 117 119 of of IN 120 125 genes gene NNS 126 128 at at IN 129 138 different different JJ 139 145 stages stage NNS 146 148 of of IN 149 161 B-lymphocyte B-lymphocyte NNP 162 165 and and CC 166 178 T-lymphocyte T-lymphocyte NNP 179 194 differentiation differentiation NN 195 197 is be VBZ 198 208 controlled control VBN 209 211 at at IN 212 215 the the DT 216 221 level level NN 222 224 of of IN 225 238 transcription transcription NN 238 239 . . . 240 241 A a DT 242 248 number number NN 249 251 of of IN 252 258 recent recent JJ 259 266 studies study NNS 267 271 have have VBP 272 281 described describe VBN 282 294 interactions interaction NNS 295 302 between between IN 303 316 transcription transcription NN 317 324 factors factor NNS 325 327 in in IN 328 339 lymphocytes lymphocyte NNS 340 344 that that WDT 345 352 provide provide VBP 353 356 new new JJ 357 365 insights insight NNS 366 370 into into IN 371 381 mechanisms mechanism NNS 382 392 regulating regulate VBG 393 397 gene gene NN 398 408 expression expression NN 408 409 . . . 410 415 These these DT 416 426 mechanisms mechanism NNS 427 434 include include VBP 435 438 the the DT 439 447 assembly assembly NN 448 450 of of IN 451 457 higher high JJR 458 463 order order NN 464 477 nucleoprotein nucleoprotein NN 478 487 complexes complex NNS 488 491 and and CC 492 497 other other JJ 498 513 protein-protein protein-protein JJ 514 526 interactions interaction NNS 527 531 that that WDT 532 539 enhance enhance VBP 540 543 the the DT 544 554 functional functional JJ 555 566 specificity specificity NN 567 569 of of IN 570 585 transcriptional transcriptional JJ 586 596 regulators regulator NNS 597 599 in in IN 600 611 lymphocytes lymphocyte NNS 611 612 . . .