0 5 C/EBP C/EBP NNP 6 16 activators activator NNS 17 20 are be VBP 21 29 required require VBN 30 33 for for IN 34 39 HIV-1 HIV-1 NNP 40 51 replication replication NN 52 55 and and CC 56 64 proviral proviral JJ 65 74 induction induction NN 75 77 in in IN 78 87 monocytic monocytic JJ 88 92 cell cell NN 93 98 lines line NNS 98 99 . . . 101 109 Previous previous JJ 110 114 work work NN 115 118 has have VBZ 119 124 shown show VBN 125 129 that that IN 130 135 C/EBP C/EBP NNP 136 141 sites site NNS 142 145 and and CC 146 151 C/EBP C/EBP NNP 152 167 transcriptional transcriptional JJ 168 178 activators activator NNS 179 182 are be VBP 183 192 necessary necessary JJ 193 196 for for IN 197 202 HIV-1 HIV-1 NNP 203 206 LTR LTR NNP 207 215 activity activity NN 216 218 in in IN 219 240 monocytes/macrophages monocytes/macrophage NNS 240 241 . . . 242 244 We we PRP 245 249 have have VBP 250 262 investigated investigate VBN 263 266 the the DT 267 271 role role NN 272 276 that that WDT 277 282 C/EBP C/EBP NNP 283 291 proteins protein NNS 292 296 play play VBP 297 299 in in IN 300 309 induction induction NN 310 313 and and CC 314 325 replication replication NN 326 328 of of IN 329 334 HIV-1 HIV-1 NNP 334 335 . . . 336 343 Ectopic ectopic JJ 344 354 expression expression NN 355 357 of of IN 358 361 the the DT 362 370 dominant dominant JJ 371 379 negative negative JJ 380 385 C/EBP C/EBP NNP 386 393 protein protein NN 394 397 LIP LIP NNP 398 407 inhibited inhibit VBD 408 413 HIV-1 HIV-1 NNP 414 418 mRNA mRNA NNP 419 422 and and CC 423 428 virus virus NN 429 439 production production NN 440 442 in in IN 443 452 activated activate VBN 453 455 U1 u1 NN 456 461 cells cell NNS 461 462 , , , 463 476 demonstrating demonstrate VBG 477 481 that that IN 482 487 C/EBP C/EBP NNP 488 496 proteins protein NNS 497 500 are be VBP 501 509 required require VBN 510 513 for for IN 514 522 provirus provirus NN 523 532 induction induction NN 532 533 . . . 534 536 U1 u1 NN 537 542 lines line NNS 543 557 overexpressing overexpresse VBG 558 563 C/EBP C/EBP NNP 564 573 activator activator NN 574 581 NF-IL-6 nf-il-6 NN 582 590 produced produce VBD 591 595 more more RBR 596 601 viral viral JJ 602 606 mRNA mrna NN 607 610 and and CC 611 616 virus virus NN 617 626 particles particle NNS 627 636 following follow VBG 637 645 cellular cellular JJ 646 656 activation activation NN 657 661 than than IN 662 669 control control NN 670 675 lines line NNS 675 676 , , , 677 690 demonstrating demonstrate VBG 691 695 that that IN 696 701 C/EBP C/EBP NNP 702 710 proteins protein NNS 711 714 are be VBP 715 723 limiting limit VBG 724 727 for for IN 728 733 virus virus NN 734 747 transcription transcription NN 747 748 . . . 749 754 HIV-1 HIV-1 NNP 755 764 harboring harbor VBG 765 774 mutations mutation NNS 775 781 within within IN 782 785 two two CD 786 791 C/EBP C/EBP NNP 792 797 sites site NNS 798 802 were be VBD 803 811 crippled cripple VBN 812 814 in in IN 815 820 their their PRP$ 821 828 ability ability NN 829 831 to to TO 832 841 replicate replicate VB 842 844 in in IN 845 849 U937 u937 NN 850 862 promonocytic promonocytic JJ 863 868 cells cell NNS 868 869 , , , 870 880 indicating indicate VBG 881 885 that that IN 886 891 these these DT 892 897 sites site NNS 898 901 are be VBP 902 910 required require VBN 911 914 for for IN 915 926 replication replication NN 926 927 . . . 928 933 These these DT 934 938 data datum NNS 939 947 identify identify VBP 948 953 C/EBP C/EBP NNP 954 962 proteins protein NNS 963 965 as as IN 966 976 regulators regulator NNS 977 979 of of IN 980 985 HIV-1 HIV-1 NNP 986 996 expression expression NN 997 999 in in IN 1000 1021 monocytes/macrophages monocytes/macrophage NNS 1021 1022 . . .