0	3	The	the	DT
4	8	role	role	NN
9	11	of	of	IN
12	17	early	early	JJ
18	24	growth	growth	NN
25	33	response	response	NN
34	38	gene	gene	NN
39	40	1	1	CD
41	42	(	(	(
42	47	egr-1	egr-1	NN
47	48	)	)	)
49	51	in	in	IN
52	62	regulation	regulation	NN
63	65	of	of	IN
66	69	the	the	DT
70	76	immune	immune	JJ
77	85	response	response	NN
85	86	.	.	.

88	91	The	the	DT
92	101	induction	induction	NN
102	104	of	of	IN
105	114	immediate	immediate	JJ
115	120	early	early	JJ
121	126	genes	gene	NNS
127	129	in	in	IN
130	135	cells	cell	NNS
136	138	of	of	IN
139	142	the	the	DT
143	149	immune	immune	JJ
150	156	system	system	NN
157	159	is	be	VBZ
160	168	critical	critical	JJ
169	171	to	to	TO
172	183	determining	determine	VBG
184	187	the	the	DT
188	196	ultimate	ultimate	JJ
197	204	outcome	outcome	NN
205	207	of	of	IN
208	216	exposure	exposure	NN
217	219	to	to	TO
220	227	antigen	antigen	NN
227	228	.	.	.

229	232	The	the	DT
233	243	importance	importance	NN
244	246	of	of	IN
247	251	many	many	JJ
252	254	of	of	IN
255	260	these	these	DT
261	266	genes	gene	NNS
267	274	relates	relate	VBZ
275	277	to	to	TO
278	281	the	the	DT
282	286	role	role	NN
287	292	their	their	PRP$
293	306	transcription	transcription	NN
307	313	factor	factor	NN
314	322	products	product	NNS
323	327	play	play	VBP
328	330	in	in	IN
331	340	dictating	dictate	VBG
341	349	patterns	pattern	NNS
350	352	of	of	IN
353	363	expression	expression	NN
364	366	of	of	IN
367	377	downstream	downstream	JJ
377	378	,	,	,
379	395	function-related	function-related	JJ
396	401	genes	gene	NNS
401	402	.	.	.

403	411	Evidence	evidence	NN
412	416	from	from	IN
417	424	several	several	JJ
425	432	systems	system	NNS
433	442	indicates	indicate	VBZ
443	447	that	that	IN
448	451	the	the	DT
452	461	immediate	immediate	JJ
462	467	early	early	JJ
468	472	gene	gene	NN
472	473	,	,	,
474	479	egr-1	egr-1	NN
480	483	may	may	MD
484	486	be	be	VB
487	489	of	of	IN
490	500	particular	particular	JJ
501	511	importance	importance	NN
512	514	in	in	IN
515	518	the	the	DT
519	525	immune	immune	JJ
526	532	system	system	NN
532	533	.	.	.

534	542	Recently	recently	RB
542	543	,	,	,
544	547	the	the	DT
548	553	egr-1	egr-1	NN
554	562	promoter	promoter	NN
563	566	has	have	VBZ
567	571	been	be	VBN
572	577	shown	show	VBN
578	580	to	to	TO
581	583	be	be	VB
584	590	highly	highly	RB
591	601	responsive	responsive	JJ
602	604	to	to	TO
605	608	the	the	DT
609	616	diverse	diverse	JJ
617	628	biochemical	biochemical	JJ
629	636	signals	signal	NNS
637	646	generated	generate	VBN
647	649	by	by	IN
650	657	antigen	antigen	NN
658	661	and	and	CC
662	671	cytokines	cytokine	NNS
672	674	in	in	IN
675	680	cells	cell	NNS
681	683	of	of	IN
684	687	the	the	DT
688	694	immune	immune	JJ
695	701	system	system	NN
701	702	.	.	.

703	714	Furthermore	furthermore	RB
714	715	,	,	,
716	718	an	an	DT
719	728	important	important	JJ
729	733	role	role	NN
734	737	for	for	IN
738	743	egr-1	egr-1	NN
744	746	in	in	IN
747	758	determining	determine	VBG
759	762	the	the	DT
763	778	differentiation	differentiation	NN
779	786	pathway	pathway	NN
787	789	of	of	IN
790	797	myeloid	myeloid	JJ
798	802	cell	cell	NN
803	813	precursors	precursor	NNS
814	817	has	have	VBZ
818	822	been	be	VBN
823	831	recently	recently	RB
832	842	elaborated	elaborate	VBN
842	843	.	.	.

844	851	Finally	finally	RB
851	852	,	,	,
853	862	potential	potential	JJ
863	870	targets	target	NNS
871	873	of	of	IN
874	884	regulation	regulation	NN
885	887	by	by	IN
888	891	the	the	DT
892	903	zinc-finger	zinc-finger	NN
904	917	transcription	transcription	NN
918	924	factor	factor	NN
925	932	encoded	encode	VBN
933	935	by	by	IN
936	941	egr-1	egr-1	NN
942	949	include	include	VBP
950	953	the	the	DT
954	967	interleukin-2	interleukin-2	NN
967	968	,	,	,
969	973	CD44	CD44	NNP
973	974	,	,	,
975	981	ICAM-1	ICAM-1	NNP
981	982	,	,	,
983	986	and	and	CC
987	992	tumor	tumor	NN
993	1001	necrosis	necrosis	NN
1002	1008	factor	factor	NN
1009	1014	genes	gene	NNS
1014	1015	.	.	.

1016	1019	The	the	DT
1020	1024	role	role	NN
1025	1027	of	of	IN
1028	1033	egr-1	egr-1	NN
1034	1036	in	in	IN
1037	1047	regulation	regulation	NN
1048	1050	of	of	IN
1051	1054	the	the	DT
1055	1061	immune	immune	JJ
1062	1070	response	response	NN
1071	1075	will	will	MD
1076	1078	be	be	VB
1079	1088	discussed	discuss	VBN
1089	1091	in	in	IN
1092	1095	the	the	DT
1096	1103	context	context	NN
1104	1106	of	of	IN
1107	1112	these	these	DT
1113	1119	recent	recent	JJ
1120	1127	studies	study	NNS
1127	1128	.	.	.