0 10 Activation Activation NNP 11 13 of of IN 14 18 Stat Stat NNP 19 21 5b 5b NN 22 24 in in IN 25 34 erythroid erythroid JJ 35 46 progenitors progenitor NNS 47 57 correlates correlate VBZ 58 62 with with IN 63 66 the the DT 67 74 ability ability NN 75 77 of of IN 78 82 ErbB ErbB NNP 83 85 to to TO 86 92 induce induce VB 93 102 sustained sustained JJ 103 107 cell cell NN 108 121 proliferation proliferation NN 121 122 . . . 124 128 Self self NN 129 136 renewal renewal NN 137 139 of of IN 140 146 normal normal JJ 147 156 erythroid erythroid JJ 157 168 progenitors progenitor NNS 169 171 is be VBZ 172 179 induced induce VBN 180 182 by by IN 183 186 the the DT 187 195 receptor receptor NN 196 204 tyrosine tyrosine NN 205 211 kinase kinase NNP 212 218 c-ErbB c-ErbB NNP 218 219 , , , 220 227 whereas whereas IN 228 233 other other JJ 234 243 receptors receptor NNS 244 245 ( ( ( 245 256 c-Kit/Epo-R c-Kit/Epo-R NNP 256 257 ) ) ) 258 266 regulate regulate VBP 267 276 erythroid erythroid JJ 277 292 differentiation differentiation NN 292 293 . . . 294 296 To to TO 297 304 address address VB 305 313 possible possible JJ 314 324 mechanisms mechanism NNS 325 329 that that WDT 330 335 could could MD 336 343 explain explain VB 344 348 this this DT 349 358 selective selective JJ 359 367 activity activity NN 368 370 of of IN 371 377 c-ErbB c-ErbB NNP 377 378 , , , 379 381 we we PRP 382 390 analyzed analyze VBD 391 394 the the DT 395 402 ability ability NN 403 405 of of IN 406 411 these these DT 412 421 receptors receptor NNS 422 424 to to TO 425 433 activate activate VB 434 437 the the DT 438 447 different different JJ 448 455 members member NNS 456 458 of of IN 459 462 the the DT 463 467 Stat Stat NNP 468 481 transcription transcription NN 482 488 factor factor NN 489 495 family family NN 495 496 . . . 497 503 Ligand Ligand NNP 504 514 activation activation NN 515 517 of of IN 518 524 c-ErbB c-ErbB NNP 525 532 induced induce VBD 533 536 the the DT 537 545 tyrosine tyrosine NN 546 561 phosphorylation phosphorylation NN 561 562 , , , 563 574 DNA-binding dna-binding NN 574 575 , , , 576 579 and and CC 580 588 reporter reporter NN 589 593 gene gene NN 594 607 transcription transcription NN 608 610 of of IN 611 615 Stat Stat NNP 616 618 5b 5b NN 619 621 in in IN 622 635 erythroblasts erythroblast NNS 635 636 . . . 637 639 In in IN 640 648 contrast contrast NN 648 649 , , , 650 656 ligand ligand NN 657 667 activation activation NN 668 670 of of IN 671 676 c-Kit c-kit NN 677 680 was be VBD 681 687 unable unable JJ 688 690 to to TO 691 697 induce induce VB 698 701 any any DT 702 704 of of IN 705 710 these these DT 711 718 effects effect NNS 719 721 in in IN 722 725 the the DT 726 730 same same JJ 731 736 cells cell NNS 736 737 . . . 738 748 Activation Activation NNP 749 751 of of IN 752 755 the the DT 756 770 erythropoietin erythropoietin NN 771 779 receptor receptor NN 780 786 caused cause VBD 787 795 specific specific JJ 796 807 DNA-binding dna-binding NN 808 810 of of IN 811 815 Stat Stat NNP 816 818 5b 5b NN 818 819 , , , 820 823 but but CC 824 830 failed fail VBD 831 833 to to TO 834 840 induce induce VB 841 849 reporter reporter NN 850 854 gene gene NN 855 868 transcription transcription NN 868 869 . . . 870 875 These these DT 876 887 biochemical biochemical JJ 888 896 findings finding NNS 897 906 correlate correlate VBP 907 916 perfectly perfectly RB 917 921 with with IN 922 925 the the DT 926 935 selective selective JJ 936 943 ability ability NN 944 946 of of IN 947 953 c-ErbB c-erbb NN 954 956 to to TO 957 962 cause cause VB 963 972 sustained sustained JJ 973 977 self self NN 978 985 renewal renewal NN 986 988 in in IN 989 998 erythroid erythroid JJ 999 1010 progenitors progenitor NNS 1010 1011 . . .