0	8	Evidence	evidence	NN
9	12	for	for	IN
13	20	lowered	lowered	JJ
21	30	induction	induction	NN
31	33	of	of	IN
34	41	nuclear	nuclear	JJ
42	48	factor	factor	NN
49	54	kappa	kappa	NN
55	56	B	b	NN
57	59	in	in	IN
60	69	activated	activate	VBN
70	75	human	human	JJ
76	77	T	t	NN
78	89	lymphocytes	lymphocyte	NNS
90	96	during	during	IN
97	102	aging	aging	NN
102	103	.	.	.

105	118	Transcription	Transcription	NNP
119	125	factor	factor	NN
126	128	NF	NF	NNP
129	134	kappa	kappa	NN
135	136	B	B	NNP
137	138	(	(	(
138	145	nuclear	nuclear	JJ
146	152	factor	factor	NN
153	158	kappa	kappa	NN
159	160	B	B	NNP
160	161	)	)	)
162	164	is	be	VBZ
165	172	induced	induce	VBN
173	175	in	in	IN
176	177	T	t	NN
178	189	lymphocytes	lymphocyte	NNS
190	194	from	from	IN
195	200	young	young	JJ
201	212	individuals	individual	NNS
213	222	following	follow	VBG
223	233	activation	activation	NN
234	238	with	with	IN
239	240	a	a	DT
241	248	variety	variety	NN
249	251	of	of	IN
252	259	stimuli	stimulus	NNS
260	269	including	include	VBG
270	278	anti-CD3	anti-cd3	NN
278	279	,	,	,
280	287	phorbol	phorbol	NN
288	297	myristate	myristate	NN
298	305	acetate	acetate	NN
306	307	(	(	(
307	310	PMA	PMA	NNP
310	311	)	)	)
311	312	,	,	,
313	316	and	and	CC
317	322	tumor	tumor	NN
323	331	necrosis	necrosis	NN
332	344	factor-alpha	factor-alpha	NN
345	346	(	(	(
346	355	TNF-alpha	TNF-alpha	NNP
355	356	)	)	)
356	357	.	.	.

358	360	In	in	IN
361	369	contrast	contrast	NN
369	370	,	,	,
371	380	activated	activate	VBN
381	382	T	t	NN
383	394	lymphocytes	lymphocyte	NNS
395	399	from	from	IN
400	405	older	old	JJR
406	417	individuals	individual	NNS
418	422	show	show	VBP
423	424	a	a	DT
425	436	significant	significant	JJ
437	446	reduction	reduction	NN
447	449	in	in	IN
450	453	the	the	DT
454	463	induction	induction	NN
464	466	of	of	IN
467	469	NF	NF	NNP
470	475	kappa	kappa	NN
476	477	B	B	NNP
478	480	in	in	IN
481	489	response	response	NN
490	492	to	to	TO
493	496	the	the	DT
497	501	same	same	JJ
502	509	stimuli	stimulus	NNS
509	510	.	.	.

511	514	The	the	DT
515	526	age-related	age-related	JJ
527	534	decline	decline	NN
535	537	in	in	IN
538	547	induction	induction	NN
548	550	of	of	IN
551	553	NF	NF	NNP
554	559	kappa	kappa	NN
560	561	B	B	NNP
562	567	could	could	MD
568	571	not	not	RB
572	574	be	be	VB
575	585	attributed	attribute	VBN
586	588	to	to	TO
589	599	alteration	alteration	NN
600	602	in	in	IN
603	606	the	the	DT
607	618	composition	composition	NN
619	621	of	of	IN
622	630	subunits	subunit	NNS
630	631	,	,	,
632	635	p50	p50	NN
636	639	and	and	CC
640	643	p65	p65	NN
644	648	were	be	VBD
649	654	found	find	VBN
655	657	to	to	TO
658	660	be	be	VB
661	664	the	the	DT
665	676	predominant	predominant	JJ
677	685	subunits	subunit	NNS
686	688	of	of	IN
689	696	induced	induce	VBN
697	699	NF	NF	NNP
700	705	kappa	kappa	NN
706	707	B	b	NN
708	710	in	in	IN
711	712	T	t	NN
713	718	cells	cell	NNS
719	723	from	from	IN
724	729	young	young	JJ
730	732	as	as	RB
733	737	well	well	RB
738	740	as	as	IN
741	748	elderly	elderly	JJ
749	755	donors	donor	NNS
755	756	.	.	.

757	768	Furthermore	furthermore	RB
768	769	,	,	,
770	777	similar	similar	JJ
778	784	levels	level	NNS
785	787	of	of	IN
788	790	NF	NF	NNP
791	796	kappa	kappa	NN
797	798	B	B	NNP
799	803	were	be	VBD
804	809	found	find	VBN
810	812	in	in	IN
813	816	the	the	DT
817	825	cytosols	cytosol	NNS
826	828	of	of	IN
829	840	unactivated	unactivated	JJ
841	842	T	t	NN
843	848	cells	cell	NNS
849	853	from	from	IN
854	858	both	both	CC
859	864	young	young	JJ
865	868	and	and	CC
869	876	elderly	elderly	JJ
877	883	donors	donor	NNS
884	894	suggesting	suggest	VBG
895	899	that	that	IN
900	909	precursor	precursor	NN
910	916	levels	level	NNS
917	919	of	of	IN
920	922	NF	NF	NNP
923	928	kappa	kappa	NN
929	930	B	B	NNP
931	937	remain	remain	VBP
938	947	unaltered	unaltered	JJ
948	954	during	during	IN
955	960	aging	aging	NN
960	961	.	.	.

962	967	These	these	DT
968	975	results	result	NNS
976	983	suggest	suggest	VBP
984	988	that	that	IN
989	991	an	an	DT
992	1006	age-associated	age-associated	JJ
1007	1014	decline	decline	NN
1015	1017	in	in	IN
1018	1021	the	the	DT
1022	1031	induction	induction	NN
1032	1034	of	of	IN
1035	1037	NF	NF	NNP
1038	1043	kappa	kappa	NN
1044	1045	B	B	NNP
1046	1048	in	in	IN
1049	1058	activated	activate	VBN
1059	1060	T	t	NN
1061	1066	cells	cell	NNS
1067	1071	from	from	IN
1072	1079	elderly	elderly	JJ
1080	1091	individuals	individual	NNS
1092	1095	may	may	MD
1096	1098	be	be	VB
1099	1111	attributable	attributable	JJ
1112	1114	to	to	TO
1115	1122	altered	altered	JJ
1123	1133	regulation	regulation	NN
1134	1136	of	of	IN
1137	1140	the	the	DT
1141	1150	inhibitor	inhibitor	NN
1150	1151	,	,	,
1152	1153	I	i	NN
1154	1159	kappa	kappa	NN
1160	1161	B	B	NNP
1161	1162	,	,	,
1163	1166	and	and	CC
1167	1170	may	may	MD
1171	1175	play	play	VB
1176	1178	an	an	DT
1179	1188	important	important	JJ
1189	1193	role	role	NN
1194	1196	in	in	IN
1197	1203	immune	immune	JJ
1204	1217	dysregulation	dysregulation	NN
1218	1230	accompanying	accompany	VBG
1231	1236	aging	aging	NN
1236	1237	.	.	.