0	11	Interaction	Interaction	NNP
12	14	of	of	IN
15	21	HTLV-I	HTLV-I	NNP
22	25	Tax	Tax	NNP
26	30	with	with	IN
31	34	the	the	DT
35	40	human	human	JJ
41	51	proteasome	proteasome	NN
51	52	:	:	:
53	65	implications	implication	NNS
66	69	for	for	IN
70	78	NF-kappa	NF-kappa	NNP
79	80	B	B	NNP
81	90	induction	induction	NN
90	91	.	.	.

93	96	The	the	DT
97	102	human	human	JJ
103	109	T-cell	t-cell	NN
110	118	leukemia	leukemia	NN
119	124	virus	virus	NN
125	129	type	type	NN
130	131	I	i	CD
132	133	(	(	(
133	139	HTLV-I	HTLV-I	NNP
139	140	)	)	)
141	144	has	have	VBZ
145	149	been	be	VBN
150	163	etiologically	etiologically	RB
164	174	associated	associate	VBN
175	179	with	with	IN
180	183	the	the	DT
184	195	development	development	NN
196	198	of	of	IN
199	202	the	the	DT
203	208	adult	adult	JJ
209	215	T-cell	t-cell	NN
216	224	leukemia	leukemia	NN
225	226	(	(	(
226	229	ATL	ATL	NNP
229	230	)	)	)
231	233	as	as	RB
234	238	well	well	RB
239	241	as	as	IN
242	254	degenerative	degenerative	JJ
255	265	neurologic	neurologic	JJ
266	274	syndrome	syndrome	NN
275	281	termed	term	VBN
282	290	tropical	tropical	JJ
291	298	spastic	spastic	JJ
299	310	paraparesis	paraparesis	NN
311	312	(	(	(
312	315	TSP	TSP	NNP
315	316	)	)	)
316	317	.	.	.

318	324	HTLV-I	HTLV-I	NNP
325	332	encodes	encode	VBZ
333	334	a	a	DT
335	341	potent	potent	JJ
342	356	transactivator	transactivator	NN
357	364	protein	protein	NN
365	371	termed	term	VBN
372	375	Tax	Tax	NNP
376	380	that	that	WDT
381	388	appears	appear	VBZ
389	391	to	to	TO
392	396	play	play	VB
397	399	an	an	DT
400	409	important	important	JJ
410	414	role	role	NN
415	417	in	in	IN
418	421	the	the	DT
422	429	process	process	NN
430	432	of	of	IN
433	439	T-cell	t-cell	NN
440	455	immortalization	immortalization	NN
455	456	.	.	.

457	461	Even	even	RB
462	468	though	though	IN
469	472	the	the	DT
473	483	mechanisms	mechanism	NNS
484	486	by	by	IN
487	492	which	which	WDT
493	496	Tax	Tax	NNP
497	504	induces	induce	VBZ
505	519	transformation	transformation	NN
520	523	are	be	VBP
524	529	still	still	RB
530	537	unknown	unknown	JJ
537	538	,	,	,
539	541	it	it	PRP
542	547	seems	seem	VBZ
548	554	likely	likely	JJ
555	559	that	that	IN
560	563	the	the	DT
564	571	ability	ability	NN
572	574	of	of	IN
575	578	Tax	Tax	NNP
579	581	to	to	TO
582	587	alter	alter	VB
588	591	the	the	DT
592	602	expression	expression	NN
603	605	of	of	IN
606	610	many	many	JJ
611	619	cellular	cellular	JJ
620	625	genes	gene	NNS
626	631	plays	play	VBZ
632	634	an	an	DT
635	644	important	important	JJ
645	649	part	part	NN
650	652	in	in	IN
653	657	this	this	DT
658	665	process	process	NN
665	666	.	.	.

667	670	Tax	Tax	NNP
671	675	does	do	VBZ
676	679	not	not	RB
680	684	bind	bind	VB
685	693	directly	directly	RB
694	696	to	to	TO
697	700	DNA	DNA	NNP
701	704	but	but	CC
705	711	rather	rather	RB
712	723	deregulates	deregulate	VBZ
724	727	the	the	DT
728	736	activity	activity	NN
737	739	of	of	IN
740	748	cellular	cellular	JJ
749	762	transcription	transcription	NN
763	770	factors	factor	NNS
770	771	.	.	.

772	775	One	one	CD
776	782	family	family	NN
783	785	of	of	IN
786	790	host	host	NN
791	804	transcription	transcription	NN
805	812	factors	factor	NNS
813	818	whose	whose	WP$
819	827	activity	activity	NN
828	830	is	be	VBZ
831	838	altered	alter	VBN
839	841	by	by	IN
842	845	Tax	Tax	NNP
846	854	includes	include	VBZ
855	863	NF-kappa	NF-kappa	NNP
864	869	B/Rel	B/Rel	NNP
869	870	.	.	.

871	876	These	these	DT
877	890	transcription	transcription	NN
891	898	factors	factor	NNS
899	902	are	be	VBP
903	925	post-transcriptionally	post-transcriptionally	RB
926	935	regulated	regulate	VBN
936	938	by	by	IN
939	944	their	their	PRP$
945	953	assembly	assembly	NN
954	958	with	with	IN
959	960	a	a	DT
961	967	second	second	JJ
968	974	family	family	NN
975	977	of	of	IN
978	988	inhibitory	inhibitory	JJ
989	997	proteins	protein	NNS
998	1004	termed	term	VBN
1005	1006	I	i	NN
1007	1012	kappa	kappa	NN
1013	1014	B	B	NNP
1015	1019	that	that	WDT
1020	1025	serve	serve	VBP
1026	1028	to	to	TO
1029	1038	sequester	sequester	VB
1039	1042	the	the	DT
1043	1051	NF-kappa	NF-kappa	NNP
1052	1057	B/Rel	B/Rel	NNP
1058	1067	complexes	complex	NNS
1068	1070	in	in	IN
1071	1074	the	the	DT
1075	1084	cytoplasm	cytoplasm	NN
1084	1085	.	.	.

1086	1090	Upon	upon	IN
1091	1099	cellular	cellular	JJ
1100	1110	activation	activation	NN
1110	1111	,	,	,
1112	1113	I	i	NN
1114	1119	kappa	kappa	NN
1120	1121	B	B	NNP
1122	1127	alpha	alpha	NN
1128	1130	is	be	VBZ
1131	1145	phosphorylated	phosphorylate	VBN
1145	1146	,	,	,
1147	1164	polyubiquitinated	polyubiquitinate	VBN
1164	1165	,	,	,
1166	1169	and	and	CC
1170	1178	degraded	degrade	VBN
1179	1181	in	in	IN
1182	1185	the	the	DT
1186	1196	proteasome	proteasome	NN
1196	1197	.	.	.

1198	1202	This	this	DT
1203	1214	proteolytic	proteolytic	JJ
1215	1220	event	event	NN
1221	1230	liberates	liberate	VBZ
1231	1239	NF-kappa	NF-kappa	NNP
1240	1241	B	B	NNP
1241	1242	,	,	,
1243	1253	permitting	permit	VBG
1254	1257	its	its	PRP$
1258	1263	rapid	rapid	JJ
1264	1277	translocation	translocation	NN
1278	1282	into	into	IN
1283	1286	the	the	DT
1287	1294	nucleus	nucleus	NN
1295	1300	where	where	WRB
1301	1303	it	it	PRP
1304	1309	binds	bind	VBZ
1310	1312	to	to	TO
1313	1316	its	its	PRP$
1317	1324	cognate	cognate	JJ
1325	1333	enhancer	enhancer	NN
1334	1342	elements	element	NNS
1342	1343	.	.	.

1344	1353	Similarly	similarly	RB
1353	1354	,	,	,
1355	1358	the	the	DT
1359	1363	p105	p105	NN
1364	1373	precursor	precursor	NN
1374	1376	of	of	IN
1377	1380	the	the	DT
1381	1389	NF-kappa	NF-kappa	NNP
1390	1391	B	B	NNP
1392	1395	p50	p50	NN
1396	1403	subunit	subunit	NN
1404	1406	is	be	VBZ
1407	1411	also	also	RB
1412	1432	post-translationally	post-translationally	RB
1433	1442	processed	process	VBN
1443	1445	in	in	IN
1446	1449	the	the	DT
1450	1460	proteasome	proteasome	NN
1460	1461	.	.	.

1462	1465	The	the	DT
1466	1476	mechanisms	mechanism	NNS
1477	1479	by	by	IN
1480	1485	which	which	WDT
1486	1489	Tax	Tax	NNP
1490	1499	activates	activate	VBZ
1500	1508	NF-kappa	NF-kappa	NNP
1509	1510	B	B	NNP
1511	1517	remain	remain	VBP
1518	1525	unclear	unclear	JJ
1525	1526	,	,	,
1527	1530	and	and	CC
1531	1539	findings	finding	NNS
1540	1549	presented	present	VBN
1550	1552	in	in	IN
1553	1556	the	the	DT
1557	1567	literature	literature	NN
1568	1571	are	be	VBP
1572	1577	often	often	RB
1578	1591	controversial	controversial	JJ
1591	1592	.	.	.

1593	1595	We	we	PRP
1596	1606	identified	identify	VBD
1607	1608	a	a	DT
1609	1617	physical	physical	JJ
1618	1629	interaction	interaction	NN
1630	1637	between	between	IN
1638	1641	Tax	Tax	NNP
1642	1645	and	and	CC
1646	1649	the	the	DT
1650	1654	HsN3	hsn3	NN
1655	1662	subunit	subunit	NN
1663	1665	of	of	IN
1666	1669	the	the	DT
1670	1675	human	human	JJ
1676	1686	proteasome	proteasome	NN
1686	1687	.	.	.

1688	1692	This	this	DT
1693	1699	raises	raise	VBZ
1700	1703	the	the	DT
1704	1714	intriguing	intriguing	JJ
1715	1726	possibility	possibility	NN
1727	1731	that	that	IN
1732	1740	physical	physical	JJ
1741	1752	association	association	NN
1753	1755	of	of	IN
1756	1759	the	the	DT
1760	1764	HsN3	hsn3	NN
1765	1775	proteasome	proteasome	NN
1776	1783	subunit	subunit	NN
1784	1788	with	with	IN
1789	1795	HTLV-I	HTLV-I	NNP
1796	1799	Tax	Tax	NNP
1800	1807	coupled	couple	VBN
1808	1812	with	with	IN
1813	1816	the	the	DT
1817	1828	independent	independent	JJ
1829	1840	interaction	interaction	NN
1841	1843	of	of	IN
1844	1847	Tax	Tax	NNP
1848	1852	with	with	IN
1853	1859	either	either	CC
1860	1864	p100	p100	NN
1865	1867	or	or	CC
1868	1873	p65-I	p65-i	NN
1874	1879	kappa	kappa	NN
1880	1881	B	B	NNP
1882	1887	alpha	alpha	NN
1888	1895	targets	target	VBZ
1896	1901	these	these	DT
1902	1913	cytoplasmic	cytoplasmic	JJ
1914	1922	NF-kappa	NF-kappa	NNP
1923	1928	B/Rel	B/Rel	NNP
1929	1938	complexes	complex	NNS
1939	1941	to	to	TO
1942	1945	the	the	DT
1946	1956	proteasome	proteasome	NN
1957	1960	for	for	IN
1961	1971	processing	processing	NN
1971	1972	.	.	.