0	12	Epstein-Barr	epstein-barr	JJ
13	18	viral	viral	JJ
19	26	latency	latency	NN
27	29	is	be	VBZ
30	39	disrupted	disrupt	VBN
40	42	by	by	IN
43	46	the	the	DT
47	62	immediate-early	immediate-early	JJ
63	68	BRLF1	brlf1	NN
69	76	protein	protein	NN
77	84	through	through	IN
85	86	a	a	DT
87	100	cell-specific	cell-specific	JJ
101	110	mechanism	mechanism	NN
110	111	.	.	.

113	125	Epstein-Barr	epstein-barr	JJ
126	131	virus	virus	NN
132	133	(	(	(
133	136	EBV	EBV	NNP
136	137	)	)	)
137	138	,	,	,
139	142	the	the	DT
143	152	causative	causative	JJ
153	158	agent	agent	NN
159	161	of	of	IN
162	172	infectious	infectious	JJ
173	186	mononucleosis	mononucleosis	NN
186	187	,	,	,
188	190	is	be	VBZ
191	192	a	a	DT
193	198	human	human	JJ
199	210	herpesvirus	herpesvirus	NN
211	221	associated	associate	VBN
222	226	with	with	IN
227	237	epithelial	epithelial	JJ
238	242	cell	cell	NN
243	255	malignancies	malignancy	NNS
256	257	(	(	(
257	271	nasopharyngeal	nasopharyngeal	JJ
272	281	carcinoma	carcinoma	NN
281	282	)	)	)
283	285	as	as	RB
286	290	well	well	RB
291	293	as	as	IN
294	300	B-cell	b-cell	NN
301	313	malignancies	malignancy	NNS
313	314	.	.	.

315	328	Understanding	understand	VBG
329	332	how	how	WRB
333	338	viral	viral	JJ
339	346	latency	latency	NN
347	349	is	be	VBZ
350	359	disrupted	disrupt	VBN
360	362	is	be	VBZ
363	364	a	a	DT
365	372	central	central	JJ
373	378	issue	issue	NN
379	381	in	in	IN
382	393	herpesvirus	herpesvirus	NN
394	401	biology	biology	NN
401	402	.	.	.

403	413	Epithelial	epithelial	JJ
414	419	cells	cell	NNS
420	423	are	be	VBP
424	427	the	the	DT
428	433	major	major	JJ
434	438	site	site	NN
439	441	of	of	IN
442	447	lytic	lytic	JJ
448	451	EBV	EBV	NNP
452	463	replication	replication	NN
464	470	within	within	IN
471	474	the	the	DT
475	480	human	human	JJ
481	485	host	host	NN
485	486	,	,	,
487	490	and	and	CC
491	496	viral	viral	JJ
497	509	reactivation	reactivation	NN
510	516	occurs	occur	VBZ
517	519	in	in	IN
520	534	EBV-associated	ebv-associated	JJ
535	549	nasopharyngeal	nasopharyngeal	JJ
550	560	carcinomas	carcinoma	NNS
560	561	.	.	.

562	564	It	it	PRP
565	567	is	be	VBZ
568	573	known	know	VBN
574	578	that	that	IN
579	589	expression	expression	NN
590	592	of	of	IN
593	594	a	a	DT
595	601	single	single	JJ
602	607	viral	viral	JJ
608	623	immediate-early	immediate-early	JJ
624	631	protein	protein	NN
631	632	,	,	,
633	638	BZLF1	BZLF1	NNP
638	639	,	,	,
640	642	is	be	VBZ
643	653	sufficient	sufficient	JJ
654	656	to	to	TO
657	665	initiate	initiate	VB
666	669	the	the	DT
670	676	switch	switch	NN
677	681	from	from	IN
682	688	latent	latent	JJ
689	691	to	to	TO
692	697	lytic	lytic	JJ
698	707	infection	infection	NN
708	710	in	in	IN
711	712	B	B	NNP
713	718	cells	cell	NNS
718	719	.	.	.

720	728	Cellular	cellular	JJ
729	739	regulation	regulation	NN
740	742	of	of	IN
743	748	BZLF1	bzlf1	NN
749	762	transcription	transcription	NN
763	765	is	be	VBZ
766	775	therefore	therefore	RB
776	783	thought	think	VBN
784	786	to	to	TO
787	791	play	play	VB
792	793	a	a	DT
794	797	key	key	JJ
798	802	role	role	NN
803	805	in	in	IN
806	816	regulating	regulate	VBG
817	820	the	the	DT
821	831	stringency	stringency	NN
832	834	of	of	IN
835	840	viral	viral	JJ
841	848	latency	latency	NN
848	849	.	.	.

850	854	Here	here	RB
855	857	we	we	PRP
858	862	show	show	VBP
863	867	that	that	IN
867	868	,	,	,
869	881	unexpectedly	unexpectedly	RB
881	882	,	,	,
883	893	expression	expression	NN
894	896	of	of	IN
897	904	another	another	DT
905	910	viral	viral	JJ
911	926	immediate-early	immediate-early	JJ
927	934	protein	protein	NN
934	935	,	,	,
936	941	BRLF1	BRLF1	NNP
941	942	,	,	,
943	946	can	can	MD
947	954	disrupt	disrupt	VB
955	960	viral	viral	JJ
961	968	latency	latency	NN
969	971	in	in	IN
972	974	an	an	DT
975	985	epithelial	epithelial	JJ
986	999	cell-specific	cell-specific	JJ
1000	1007	fashion	fashion	NN
1007	1008	.	.	.

1009	1018	Therefore	therefore	RB
1018	1019	,	,	,
1020	1023	the	the	DT
1024	1034	mechanisms	mechanism	NNS
1035	1042	leading	lead	VBG
1043	1045	to	to	TO
1046	1056	disruption	disruption	NN
1057	1059	of	of	IN
1060	1063	EBV	EBV	NNP
1064	1071	latency	latency	NN
1072	1078	appear	appear	VBP
1079	1081	to	to	TO
1082	1084	be	be	VB
1085	1094	cell-type	cell-type	JJ
1095	1103	specific	specific	JJ
1103	1104	.	.	.