0 16 Characterization characterization NN 17 19 of of IN 20 23 the the DT 24 29 human human JJ 30 37 myeloid myeloid JJ 38 42 cell cell NN 43 50 nuclear nuclear JJ 51 66 differentiation differentiation NN 67 74 antigen antigen NN 75 79 gene gene NN 80 88 promoter promoter NN 88 89 . . . 91 95 MNDA MNDA NNP 96 97 ( ( ( 97 104 myeloid myeloid JJ 105 109 cell cell NN 110 117 nuclear nuclear JJ 118 133 differentiation differentiation NN 134 141 antigen antigen NN 141 142 ) ) ) 143 145 is be VBZ 146 148 an an DT 149 159 interferon interferon NN 160 165 alpha alpha NN 166 175 regulated regulate VBD 176 183 nuclear nuclear JJ 184 191 protein protein NN 192 201 expressed express VBN 202 206 only only RB 207 209 in in IN 210 215 cells cell NNS 216 218 of of IN 219 222 the the DT 223 228 human human JJ 229 243 myelomonocytic myelomonocytic JJ 244 251 lineage lineage NN 251 252 . . . 253 255 To to TO 256 264 identify identify VB 265 275 mechanisms mechanism NNS 276 287 responsible responsible JJ 288 291 for for IN 292 296 this this DT 297 313 lineage-specific lineage-specific JJ 314 317 and and CC 318 338 interferon-regulated interferon-regulated JJ 339 349 expression expression NN 349 350 , , , 351 354 the the DT 355 356 5 5 CD 356 357 ’ ' SYM 358 366 flanking flanking NN 367 375 sequence sequence NN 376 378 of of IN 379 382 the the DT 383 387 gene gene NN 388 391 has have VBZ 392 396 been be VBN 397 410 characterized characterize VBN 410 411 . . . 412 415 Two two CD 416 437 interferon-stimulated interferon-stimulated JJ 438 446 response response NN 447 455 elements element NNS 456 457 ( ( ( 457 461 ISRE isre NN 461 462 ) ) ) 463 468 flank flank VBP 469 470 a a DT 471 479 multiple multiple JJ 480 493 transcription transcription NN 494 499 start start NN 500 504 site site NN 505 511 region region NN 512 523 identifying identify VBG 524 528 MNDA MNDA NNP 529 531 as as IN 532 533 a a DT 534 543 TATA-less tata-less JJ 544 564 interferon-regulated interferon-regulated JJ 565 569 gene gene NN 569 570 . . . 571 576 Other other JJ 577 580 DNA dna NN 581 589 elements element NNS 590 597 present present JJ 598 605 include include VBP 606 607 a a DT 608 615 cluster cluster NN 616 618 of of IN 619 622 Myb Myb NNP 623 628 sites site NNS 628 629 , , , 630 637 several several JJ 638 641 Ets et NNS 641 642 , , , 643 645 an an DT 646 649 Ets ets NN 650 657 related related JJ 658 662 PU.1 pu.1 NN 663 667 site site NN 668 671 and and CC 672 674 an an DT 675 678 Sp1 sp1 NN 679 683 site site NN 684 691 located located JJ 692 698 within within IN 699 702 600 600 CD 703 705 bp bp NN 706 708 of of IN 709 712 the the DT 713 726 transcription transcription NN 727 732 start start NN 733 738 sites site NNS 738 739 . . . 740 742 In in IN 743 751 addition addition NN 751 752 , , , 753 756 DNA DNA NNP 757 768 methylation methylation NN 769 772 was be VBD 773 781 revealed reveal VBN 782 784 as as IN 785 788 one one CD 789 791 of of IN 792 795 the the DT 796 804 possible possible JJ 805 812 factors factor NNS 813 815 in in IN 816 828 establishing establish VBG 829 833 MNDA MNDA NNP 834 844 expression expression NN 844 845 . . . 846 849 The the DT 850 851 5 5 CD 851 852 ’ ' SYM 853 861 flanking flanking NN 862 870 sequence sequence NN 871 874 has have VBZ 875 883 promoter promoter NN 884 892 activity activity NN 893 898 which which WDT 899 901 is be VBZ 902 910 elevated elevate VBN 911 913 by by IN 914 924 interferon interferon NN 925 930 alpha alpha NN 930 931 . . . 932 935 The the DT 936 944 findings finding NNS 945 953 indicate indicate VBP 954 958 that that IN 959 963 MNDA MNDA NNP 964 974 expression expression NN 975 977 is be VBZ 978 987 regulated regulate VBN 988 990 by by IN 991 1001 mechanisms mechanism NNS 1002 1009 similar similar JJ 1010 1012 to to TO 1013 1018 other other JJ 1019 1033 myelomonocytic myelomonocytic JJ 1034 1038 cell cell NN 1039 1047 specific specific JJ 1048 1053 genes gene NNS 1054 1057 and and CC 1058 1063 genes gene NNS 1064 1076 up-regulated up-regulate VBN 1077 1079 by by IN 1080 1090 interferon interferon NN 1091 1096 alpha alpha NN 1096 1097 . . .