0 10 Regulation regulation NN 11 13 of of IN 14 22 cytokine cytokine NN 23 26 and and CC 27 35 cytokine cytokine NN 36 44 receptor receptor NN 45 55 expression expression NN 56 58 by by IN 59 74 glucocorticoids glucocorticoid NNS 74 75 . . . 77 92 Glucocorticoids Glucocorticoid NNP 93 94 ( ( ( 94 97 GCS GCS NNP 97 98 ) ) ) 99 109 profoundly profoundly RB 110 117 inhibit inhibit VBP 118 125 several several JJ 126 133 aspects aspect NNS 134 136 of of IN 137 138 T t NN 139 143 cell cell NN 144 152 immunity immunity NN 153 160 largely largely RB 161 168 through through IN 169 179 inhibition inhibition NN 180 182 of of IN 183 191 cytokine cytokine NN 192 202 expression expression NN 203 205 at at IN 206 209 the the DT 210 225 transcriptional transcriptional JJ 226 229 and and CC 230 249 posttranscriptional posttranscriptional JJ 250 256 levels level NNS 256 257 . . . 258 261 GCS gcs NNS 262 266 were be VBD 267 271 also also RB 272 280 reported report VBN 281 283 to to TO 284 287 act act VB 288 298 indirectly indirectly RB 299 301 by by IN 302 310 inducing induce VBG 311 323 transforming transform VBG 324 330 growth growth NN 331 342 factor-beta factor-beta NN 343 353 expression expression NN 353 354 , , , 355 360 which which WDT 361 363 in in IN 364 368 turn turn NN 369 375 blocks block VBZ 376 377 T t NN 378 382 cell cell NN 383 391 immunity immunity NN 391 392 . . . 393 395 In in IN 396 404 exerting exert VBG 405 410 their their PRP$ 411 428 antiproliferative antiproliferative JJ 429 436 effects effect NNS 436 437 , , , 438 441 GCS gcs NNS 442 449 diffuse diffuse VBP 450 454 into into IN 455 461 target target NN 462 467 cells cell NNS 468 473 where where WRB 474 478 they they PRP 479 483 bind bind VBP 484 489 their their PRP$ 490 501 cytoplasmic cytoplasmic JJ 502 510 receptor receptor NN 510 511 , , , 512 517 which which WDT 518 520 in in IN 521 525 turn turn NN 526 538 translocates translocate VBZ 539 541 to to TO 542 545 the the DT 546 553 nucleus nucleus NN 554 559 where where WRB 560 562 it it PRP 563 571 inhibits inhibit VBZ 572 585 transcription transcription NN 586 588 of of IN 589 597 cytokine cytokine NN 598 603 genes gene NNS 604 611 through through IN 612 618 direct direct JJ 619 626 binding binding NN 627 629 to to TO 630 633 the the DT 634 648 glucocorticoid glucocorticoid NN 649 657 response response NN 658 666 elements element NNS 667 668 ( ( ( 668 671 GRE GRE NNP 671 672 ) ) ) 672 673 , , , 674 679 which which WDT 680 683 are be VBP 684 691 located located JJ 692 694 in in IN 695 698 the the DT 699 707 promoter promoter NN 708 714 region region NN 715 717 of of IN 718 726 cytokine cytokine NN 727 732 genes gene NNS 733 735 or or CC 735 736 , , , 737 750 alternatively alternatively RB 750 751 , , , 752 759 through through IN 760 770 antagonism antagonism NN 771 773 of of IN 774 777 the the DT 778 784 action action NN 785 787 of of IN 788 801 transcription transcription NN 802 809 factors factor NNS 810 818 required require VBN 819 822 for for IN 823 830 optimal optimal JJ 831 846 transcriptional transcriptional JJ 847 857 activation activation NN 857 858 . . . 859 861 In in IN 862 870 contrast contrast NN 871 873 to to TO 874 879 their their PRP$ 880 890 inhibitory inhibitory JJ 891 898 effects effect NNS 899 901 on on IN 902 910 cytokine cytokine NN 911 921 expression expression NN 921 922 , , , 923 926 GCS GCS NNP 927 938 up-regulate up-regulate VBP 939 947 cytokine cytokine NN 948 956 receptor receptor NN 957 967 expression expression NN 968 972 that that WDT 973 983 correlates correlate VBZ 984 988 with with IN 989 997 enhanced enhance VBN 998 1006 cytokine cytokine NN 1007 1014 effects effect NNS 1015 1017 on on IN 1018 1024 target target NN 1025 1030 cells cell NNS 1030 1031 . . . 1032 1034 In in IN 1035 1039 this this DT 1040 1046 review review NN 1046 1047 , , , 1048 1050 we we PRP 1051 1060 summarize summarize VBP 1061 1064 the the DT 1065 1072 current current JJ 1073 1078 state state NN 1079 1081 of of IN 1082 1091 knowledge knowledge NN 1092 1094 of of IN 1095 1098 the the DT 1099 1108 mechanism mechanism NN 1109 1111 of of IN 1112 1118 action action NN 1119 1121 of of IN 1122 1125 GCS GCS NNP 1125 1126 , , , 1127 1136 including include VBG 1137 1140 the the DT 1141 1151 phenomenon phenomenon NN 1152 1154 of of IN 1155 1170 steroid-induced steroid-induced JJ 1171 1178 rebound rebound NN 1178 1179 , , , 1180 1185 which which WDT 1186 1192 ensues ensue VBZ 1193 1197 upon upon IN 1198 1201 GCS GCS NNP 1202 1212 withdrawal withdrawal NN 1212 1213 . . .