0 3 The the DT 4 9 Oct-2 oct-2 NN 10 23 transcription transcription NN 24 30 factor factor NN 30 31 . . . 33 36 The the DT 37 42 Oct-2 oct-2 NN 43 56 transcription transcription NN 57 63 factor factor NN 64 66 is be VBZ 67 68 a a DT 69 75 member member NN 76 78 of of IN 79 82 the the DT 83 86 POU POU NNP 87 88 ( ( ( 88 99 Pit-Oct-Unc Pit-Oct-Unc NNP 99 100 ) ) ) 101 107 family family NN 108 110 of of IN 111 124 transcription transcription NN 125 132 factors factor NNS 133 136 and and CC 137 139 is be VBZ 140 149 expressed express VBN 150 154 only only RB 155 157 in in IN 158 159 B B NNP 160 171 lymphocytes lymphocyte NNS 172 175 and and CC 176 178 in in IN 179 187 neuronal neuronal JJ 188 193 cells cell NNS 194 197 but but CC 198 201 not not RB 202 204 in in IN 205 210 other other JJ 211 215 cell cell NN 216 221 types type NNS 221 222 . . . 223 226 The the DT 227 234 primary primary JJ 235 238 RNA RNA NNP 239 249 transcript transcript NN 250 252 of of IN 253 256 the the DT 257 261 gene gene NN 262 264 is be VBZ 265 272 subject subject JJ 273 275 to to TO 276 287 alternative alternative JJ 288 296 splicing splicing NN 297 299 to to TO 300 305 yield yield VB 306 315 different different JJ 316 324 variants variant NNS 325 330 which which WDT 331 334 can can MD 335 341 either either CC 342 350 activate activate VB 351 353 or or CC 354 361 repress repress VB 362 366 gene gene NN 367 377 expression expression NN 377 378 . . . 379 382 The the DT 383 388 forms form NNS 389 397 produced produce VBN 398 400 in in IN 401 402 B B NNP 403 414 lymphocytes lymphocyte NNS 415 419 have have VBP 420 421 a a DT 422 435 predominantly predominantly RB 436 446 activating activate VBG 447 453 effect effect NN 454 456 on on IN 457 461 gene gene NN 462 472 expression expression NN 473 480 whereas whereas IN 481 486 those those DT 487 495 produced produce VBN 496 498 in in IN 499 507 neuronal neuronal JJ 508 513 cells cell NNS 514 518 have have VBP 519 520 a a DT 521 534 predominantly predominantly RB 535 545 inhibitory inhibitory JJ 546 552 effect effect NN 553 556 and and CC 557 560 can can MD 561 568 repress repress VB 569 572 the the DT 573 583 expression expression NN 584 586 of of IN 587 591 both both CC 592 595 the the DT 596 602 herpes herpes NN 603 610 simplex simplex NN 611 616 virus virus NN 617 632 immediate-early immediate-early JJ 633 638 genes gene NNS 639 642 and and CC 643 646 the the DT 647 655 cellular cellular JJ 656 664 tyrosine tyrosine NN 665 676 hydroxylase hydroxylase NN 677 681 gene gene NN 681 682 . . . 683 687 Thus thus RB 688 693 Oct-2 oct-2 NN 694 699 plays play VBZ 700 702 an an DT 703 712 important important JJ 713 717 role role NN 718 720 in in IN 721 724 the the DT 725 735 regulation regulation NN 736 738 of of IN 739 747 cellular cellular JJ 748 752 gene gene NN 753 763 expression expression NN 764 766 in in IN 767 771 both both CC 772 773 B B NNP 774 779 cells cell NNS 780 783 and and CC 784 792 neuronal neuronal JJ 793 798 cells cell NNS 799 801 as as RB 802 806 well well RB 807 809 as as IN 810 812 in in IN 813 816 the the DT 817 824 control control NN 825 827 of of IN 828 833 viral viral JJ 834 841 latency latency NN 841 842 . . .