0	7	Nuclear	nuclear	JJ
8	21	factor-kappaB	factor-kappaB	NNP
22	32	activation	activation	NN
33	35	in	in	IN
36	41	human	human	JJ
42	51	monocytes	monocyte	NNS
52	62	stimulated	stimulate	VBN
63	67	with	with	IN
68	86	lipopolysaccharide	lipopolysaccharide	NN
87	89	is	be	VBZ
90	99	inhibited	inhibit	VBN
100	102	by	by	IN
103	113	fibroblast	fibroblast	NN
114	125	conditioned	conditioned	JJ
126	132	medium	medium	NN
133	136	and	and	CC
137	146	exogenous	exogenous	JJ
147	151	PGE2	pge2	NN
151	152	.	.	.

154	157	The	the	DT
158	165	nuclear	nuclear	JJ
166	172	factor	factor	NN
173	179	kappaB	kappaB	NNP
180	181	(	(	(
181	190	NF-kappaB	NF-kappaB	NNP
190	191	)	)	)
192	194	is	be	VBZ
195	202	thought	think	VBN
203	205	to	to	TO
206	208	be	be	VB
209	218	crucially	crucially	RB
219	227	involved	involve	VBN
228	230	in	in	IN
231	234	the	the	DT
235	239	gene	gene	NN
240	250	activation	activation	NN
251	253	of	of	IN
254	261	several	several	JJ
262	271	cytokines	cytokine	NNS
271	272	,	,	,
273	282	including	include	VBG
283	288	tumor	tumor	NN
289	297	necrosis	necrosis	NN
298	304	factor	factor	NN
305	310	alpha	alpha	NN
311	312	(	(	(
312	315	TNF	TNF	NNP
315	316	)	)	)
316	317	.	.	.

318	328	Previously	previously	RB
328	329	,	,	,
330	332	we	we	PRP
333	339	showed	show	VBD
340	344	that	that	IN
345	355	fibroblast	fibroblast	NN
356	367	conditioned	conditioned	JJ
368	374	medium	medium	NN
375	376	(	(	(
376	379	FCM	FCM	NNP
379	380	)	)	)
381	383	is	be	VBZ
384	388	able	able	JJ
389	391	to	to	TO
392	399	inhibit	inhibit	VB
400	404	both	both	CC
405	408	TNF	TNF	NNP
409	413	mRNA	mrna	NN
414	426	accumulation	accumulation	NN
427	430	and	and	CC
431	438	protein	protein	NN
439	446	release	release	NN
447	449	in	in	IN
450	460	peripheral	peripheral	JJ
461	474	blood-derived	blood-derived	JJ
475	480	human	human	JJ
481	490	monocytes	monocyte	NNS
491	492	(	(	(
492	495	PBM	PBM	NNP
495	496	)	)	)
497	507	stimulated	stimulate	VBN
508	512	with	with	IN
513	531	lipopolysaccharide	lipopolysaccharide	NN
532	533	(	(	(
533	536	LPS	LPS	NNP
536	537	)	)	)
537	538	.	.	.

539	541	In	in	IN
542	546	this	this	DT
547	552	study	study	NN
553	555	we	we	PRP
556	560	have	have	VBP
561	573	investigated	investigate	VBN
574	577	the	the	DT
578	584	effect	effect	NN
585	587	of	of	IN
588	591	FCM	FCM	NNP
592	594	on	on	IN
595	598	the	the	DT
599	610	LPS-induced	lps-induced	JJ
611	622	DNA-binding	dna-binding	JJ
623	631	activity	activity	NN
632	634	of	of	IN
635	644	NF-kappaB	NF-kappaB	NNP
644	645	,	,	,
646	648	by	by	IN
649	654	means	mean	NNS
655	657	of	of	IN
658	673	electrophoretic	electrophoretic	JJ
674	679	shift	shift	NN
680	685	assay	assay	NN
686	687	(	(	(
687	691	EMSA	EMSA	NNP
691	692	)	)	)
692	693	.	.	.

694	696	We	we	PRP
697	704	provide	provide	VBP
705	713	evidence	evidence	NN
714	718	that	that	IN
719	722	FCM	FCM	NNP
723	731	strongly	strongly	RB
732	740	inhibits	inhibit	VBZ
741	744	the	the	DT
745	756	LPS-induced	lps-induced	JJ
757	766	NF-kappaB	NF-kappaB	NNP
767	777	activation	activation	NN
778	780	in	in	IN
781	784	PBM	PBM	NNP
784	785	.	.	.

786	797	Furthermore	furthermore	RB
797	798	,	,	,
799	801	we	we	PRP
802	806	show	show	VBP
807	811	that	that	IN
812	821	exogenous	exogenous	JJ
822	826	PGE2	pge2	NN
827	833	mimics	mimic	VBZ
834	837	the	the	DT
838	847	NF-kappaB	NF-kappaB	NNP
848	858	inhibitory	inhibitory	JJ
859	865	effect	effect	NN
866	868	of	of	IN
869	872	FCM	FCM	NNP
872	873	.	.	.

874	876	On	on	IN
877	880	the	the	DT
881	886	other	other	JJ
887	891	hand	hand	NN
891	892	,	,	,
893	896	FCM	FCM	NNP
897	905	produced	produce	VBN
906	908	in	in	IN
909	912	the	the	DT
913	921	presence	presence	NN
922	924	of	of	IN
925	937	indomethacin	indomethacin	NN
938	942	does	do	VBZ
943	946	not	not	RB
947	954	inhibit	inhibit	VB
955	964	NF-kappaB	NF-kappaB	NNP
965	975	activation	activation	NN
976	978	by	by	IN
979	982	LPS	LPS	NNP
982	983	.	.	.

984	987	Our	our	PRP$
988	995	results	result	NNS
996	1000	lend	lend	VBP
1001	1008	further	further	JJ
1009	1016	support	support	NN
1017	1019	to	to	TO
1020	1023	the	the	DT
1024	1034	hypothesis	hypothesis	NN
1035	1039	that	that	IN
1040	1052	inflammatory	inflammatory	JJ
1053	1056	and	and	CC
1057	1063	immune	immune	JJ
1064	1073	responses	response	NNS
1074	1076	of	of	IN
1077	1098	monocytes/macrophages	monocytes/macrophage	NNS
1099	1102	may	may	MD
1103	1105	be	be	VB
1106	1115	modulated	modulate	VBN
1116	1118	at	at	IN
1119	1122	the	the	DT
1123	1132	molecular	molecular	JJ
1133	1138	level	level	NN
1139	1141	by	by	IN
1142	1149	signals	signal	NNS
1150	1161	originating	originate	VBG
1162	1166	from	from	IN
1167	1173	tissue	tissue	NN
1174	1184	structural	structural	JJ
1185	1190	cells	cell	NNS
1191	1195	such	such	JJ
1196	1198	as	as	IN
1199	1210	fibroblasts	fibroblast	NNS
1210	1211	.	.	.