0 10 Inhibitory inhibitory JJ 11 17 effect effect NN 18 20 of of IN 21 27 growth growth NN 28 35 hormone hormone NN 36 38 on on IN 39 48 TNF-alpha TNF-alpha NNP 49 58 secretion secretion NN 59 62 and and CC 63 70 nuclear nuclear JJ 71 84 factor-kappaB factor-kappab NN 85 98 translocation translocation NN 99 101 in in IN 102 131 lipopolysaccharide-stimulated lipopolysaccharide-stimulated JJ 132 137 human human JJ 138 147 monocytes monocyte NNS 147 148 . . . 150 157 Several several JJ 158 165 studies study NNS 166 170 have have VBP 171 178 pointed point VBN 179 181 to to TO 182 183 a a DT 184 188 link link NN 189 196 between between IN 197 203 immune immune JJ 204 207 and and CC 208 217 endocrine endocrine JJ 218 225 systems system NNS 225 226 , , , 227 236 including include VBG 237 238 a a DT 239 249 regulatory regulatory JJ 250 258 function function NN 259 261 of of IN 262 264 GH GH NNP 265 267 on on IN 268 276 monocyte monocyte NN 277 287 activation activation NN 287 288 . . . 289 292 The the DT 293 300 present present JJ 301 306 study study NN 307 319 demonstrates demonstrate VBZ 320 324 that that IN 325 330 human human JJ 331 336 THP-1 thp-1 NN 337 349 promonocytic promonocytic JJ 350 355 cells cell NNS 355 356 , , , 357 367 engineered engineer VBN 368 370 by by IN 371 375 gene gene NN 376 384 transfer transfer NN 385 387 to to TO 388 402 constitutively constitutively RB 403 410 produce produce VB 411 416 human human JJ 417 423 growth growth NN 424 431 hormone hormone NN 432 433 ( ( ( 433 436 hGH hGH NNP 436 437 ) ) ) 437 438 , , , 439 447 secreted secrete VBN 448 457 depressed depressed JJ 458 465 amounts amount NNS 466 468 of of IN 469 478 TNF-alpha TNF-alpha NNP 479 481 in in IN 482 490 response response NN 491 493 to to TO 494 503 challenge challenge VB 504 506 by by IN 507 510 LPS LPS NNP 510 511 . . . 512 515 The the DT 516 522 effect effect NN 523 525 of of IN 526 528 GH GH NNP 529 536 appears appear VBZ 537 539 to to TO 540 545 occur occur VB 546 548 in in IN 549 551 an an DT 552 561 autocrine autocrine JJ 562 569 fashion fashion NN 569 570 , , , 571 576 since since IN 577 580 the the DT 581 591 inhibitory inhibitory JJ 592 598 effect effect NN 599 601 on on IN 602 611 TNF-alpha TNF-alpha NNP 612 621 secretion secretion NN 622 624 by by IN 625 637 constitutive constitutive JJ 638 640 GH GH NNP 641 651 production production NN 652 657 could could MD 658 660 be be VB 661 670 abolished abolish VBN 671 673 in in IN 674 677 the the DT 678 686 presence presence NN 687 689 of of IN 690 698 anti-hGH anti-hgh JJ 699 702 mAb mab NN 702 703 . . . 704 707 The the DT 708 718 GH-induced gh-induced JJ 719 729 inhibitory inhibitory JJ 730 736 effect effect NN 737 740 was be VBD 741 745 also also RB 746 754 observed observe VBN 755 760 using use VBG 761 767 normal normal JJ 768 773 human human JJ 774 783 monocytes monocyte NNS 784 787 and and CC 788 804 monocyte-derived monocyte-derived JJ 805 816 macrophages macrophage NNS 816 817 . . . 818 828 Inhibition Inhibition NNP 829 831 of of IN 832 841 TNF-alpha TNF-alpha NNP 842 852 production production NN 853 855 by by IN 856 877 THP-1-hGH-transfected thp-1-hgh-transfected JJ 878 883 cells cell NNS 884 892 cultured culture VBN 893 895 in in IN 896 899 the the DT 900 908 presence presence NN 909 911 of of IN 912 915 LPS LPS NNP 916 918 is be VBZ 919 928 dependent dependent JJ 929 931 on on IN 932 933 a a DT 934 943 selective selective JJ 944 951 pathway pathway NN 951 952 , , , 953 958 since since IN 959 961 no no DT 962 972 inhibition inhibition NN 973 975 of of IN 976 985 TNF-alpha TNF-alpha NNP 986 996 production production NN 997 1000 was be VBD 1001 1009 observed observe VBN 1010 1014 when when WRB 1015 1020 cells cell NNS 1021 1025 were be VBD 1026 1034 cultured culture VBN 1035 1037 in in IN 1038 1041 the the DT 1042 1050 presence presence NN 1051 1053 of of IN 1054 1057 PMA PMA NNP 1057 1058 . . . 1059 1069 Inhibition Inhibition NNP 1070 1072 of of IN 1073 1082 TNF-alpha TNF-alpha NNP 1083 1092 secretion secretion NN 1093 1095 by by IN 1096 1110 LPS-stimulated lps-stimulated JJ 1111 1120 THP-1-hGH THP-1-hGH NNP 1121 1126 cells cell NNS 1127 1130 was be VBD 1131 1141 associated associate VBN 1142 1146 with with IN 1147 1148 a a DT 1149 1157 decrease decrease NN 1158 1160 in in IN 1161 1168 nuclear nuclear JJ 1169 1182 translocation translocation NN 1183 1185 of of IN 1186 1193 nuclear nuclear JJ 1194 1207 factor-kappaB factor-kappab NN 1207 1208 . . . 1209 1212 The the DT 1213 1221 capacity capacity NN 1222 1224 of of IN 1225 1227 GH GH NNP 1228 1230 to to TO 1231 1238 inhibit inhibit VB 1239 1250 LPS-induced lps-induced JJ 1251 1260 TNF-alpha TNF-alpha NNP 1261 1271 production production NN 1272 1274 by by IN 1275 1284 monocytes monocyte NNS 1285 1292 without without IN 1293 1301 altering alter VBG 1302 1307 other other JJ 1308 1316 pathways pathway NNS 1317 1324 leading lead VBG 1325 1327 to to TO 1328 1337 TNF-alpha TNF-alpha NNP 1338 1348 production production NN 1349 1352 may may MD 1353 1355 be be VB 1356 1358 of of IN 1359 1368 potential potential JJ 1369 1378 relevance relevance NN 1379 1381 in in IN 1382 1388 septic septic JJ 1389 1394 shock shock NN 1394 1395 , , , 1396 1401 since since IN 1402 1404 GH GH NNP 1405 1407 is be VBZ 1408 1417 available available JJ 1418 1421 for for IN 1422 1430 clinical clinical JJ 1431 1434 use use NN 1434 1435 . . .