0 10 Expression expression NN 11 13 of of IN 14 32 erythroid-specific erythroid-specific JJ 33 38 genes gene NNS 39 41 in in IN 42 58 megakaryoblastic megakaryoblastic JJ 59 68 disorders disorder NNS 68 69 . . . 71 80 Currently currently RB 81 90 available available JJ 91 95 data datum NNS 96 104 indicate indicate VBP 105 109 that that IN 110 119 erythroid erythroid JJ 120 123 and and CC 124 138 megakaryocytic megakaryocytic JJ 139 154 differentiation differentiation NN 155 163 pathways pathway NNS 164 167 are be VBP 168 175 closely closely RB 176 183 related related JJ 184 186 to to TO 187 191 each each DT 192 197 other other JJ 197 198 , , , 199 202 and and CC 203 208 there there EX 209 212 may may MD 213 218 exist exist VB 219 229 progenitor progenitor NN 230 235 cells cell NNS 236 242 common common JJ 243 245 to to TO 246 251 those those DT 252 255 two two CD 256 264 lineages lineage NNS 265 268 may may MD 269 274 exist exist VB 274 275 . . . 276 281 Acute acute JJ 282 298 megakaryoblastic megakaryoblastic JJ 299 307 leukemia leukemia NN 308 309 ( ( ( 309 315 AML-M7 AML-M7 NNP 315 316 ) ) ) 317 320 and and CC 321 330 transient transient JJ 331 349 myeloproliferative myeloproliferative JJ 350 358 disorder disorder NN 359 361 in in IN 362 366 Down Down NNP 366 368 ’s 's POS 369 377 syndrome syndrome NN 378 379 ( ( ( 379 382 TMD TMD NNP 382 383 ) ) ) 384 387 are be VBP 388 401 characterized characterize VBN 402 404 by by IN 405 410 rapid rapid JJ 411 417 growth growth NN 418 420 of of IN 421 429 abnormal abnormal JJ 430 435 blast blast NN 436 441 cells cell NNS 442 447 which which WDT 448 455 express express VBP 456 470 megakaryocytic megakaryocytic JJ 471 478 markers marker NNS 478 479 . . . 480 485 These these DT 486 491 blast blast NN 492 497 cells cell NNS 498 505 express express VBP 506 522 lineage-specific lineage-specific JJ 523 536 transcription transcription NN 537 544 factors factor NNS 545 549 such such JJ 550 552 as as IN 553 559 GATA-1 gata-1 NN 560 566 common common JJ 567 569 to to TO 570 575 these these DT 576 584 lineages lineage NNS 585 588 and and CC 589 599 frequently frequently RB 600 607 express express VBP 608 626 erythroid-specific erythroid-specific JJ 627 632 mRNAs mrna NNS 633 637 such such JJ 638 640 as as IN 641 653 gamma-globin gamma-globin NN 654 657 and and CC 658 667 erythroid erythroid JJ 668 689 delta-aminolevulinate delta-aminolevulinate NN 690 698 synthase synthase NN 699 700 ( ( ( 700 706 ALAS-E ALAS-E NNP 706 707 ) ) ) 707 708 , , , 709 719 indicating indicate VBG 720 724 that that IN 725 729 most most JJS 730 732 of of IN 733 736 the the DT 737 743 blasts blast NNS 744 746 in in IN 747 749 M7 M7 NNP 750 753 and and CC 754 757 TMD TMD NNP 758 763 cases case NNS 764 768 have have VBP 769 778 erythroid erythroid JJ 779 782 and and CC 783 797 megakaryocytic megakaryocytic JJ 798 808 phenotypes phenotype NNS 808 809 . . . 810 815 These these DT 816 823 results result NNS 824 831 suggest suggest VBP 832 836 that that IN 837 843 blasts blast NNS 844 846 in in IN 847 849 M7 M7 NNP 850 853 and and CC 854 857 TMD TMD NNP 858 861 may may MD 862 872 correspond correspond VB 873 875 to to TO 876 887 progenitors progenitor NNS 888 890 of of IN 891 895 both both CC 896 905 erythroid erythroid JJ 906 909 and and CC 910 924 megakaryocytic megakaryocytic JJ 925 933 lineages lineage NNS 933 934 . . .