0	13	Transcription	Transcription	NNP
14	22	mediated	mediate	VBN
23	25	by	by	IN
26	30	NFAT	NFAT	NNP
31	33	is	be	VBZ
34	40	highly	highly	RB
41	50	inducible	inducible	JJ
51	53	in	in	IN
54	62	effector	effector	NN
63	67	CD4+	cd4+	JJ
68	69	T	t	NN
70	76	helper	helper	NN
77	78	2	2	CD
79	80	(	(	(
80	83	Th2	th2	NN
83	84	)	)	)
85	90	cells	cell	NNS
91	94	but	but	CC
95	98	not	not	RB
99	101	in	in	IN
102	105	Th1	th1	NN
106	111	cells	cell	NNS
111	112	.	.	.

114	129	Transcriptional	transcriptional	JJ
130	137	factors	factor	NNS
138	140	of	of	IN
141	144	the	the	DT
145	149	NFAT	NFAT	NNP
150	156	family	family	NN
157	161	play	play	VBP
162	164	an	an	DT
165	174	important	important	JJ
175	179	role	role	NN
180	182	in	in	IN
183	193	regulating	regulate	VBG
194	197	the	the	DT
198	208	expression	expression	NN
209	211	of	of	IN
212	219	several	several	JJ
220	228	cytokine	cytokine	NN
229	234	genes	gene	NNS
235	241	during	during	IN
242	245	the	the	DT
246	252	immune	immune	JJ
253	261	response	response	NN
261	262	,	,	,
263	267	such	such	JJ
268	270	as	as	IN
271	274	the	the	DT
275	280	genes	gene	NNS
281	284	for	for	IN
285	296	interleukin	interleukin	NN
297	298	2	2	CD
299	300	(	(	(
300	304	IL-2	il-2	NN
304	305	)	)	)
306	309	and	and	CC
310	314	IL-4	il-4	NN
314	315	,	,	,
316	321	among	among	IN
322	328	others	other	NNS
328	329	.	.	.

330	334	Upon	upon	IN
335	342	antigen	antigen	NN
343	354	stimulation	stimulation	NN
354	355	,	,	,
356	365	precursor	precursor	NN
366	370	CD4+	cd4+	JJ
371	372	T	t	NN
373	379	helper	helper	NN
380	381	(	(	(
381	384	pTh	pth	NN
384	385	)	)	)
386	391	cells	cell	NNS
392	403	proliferate	proliferate	VBP
404	407	and	and	CC
408	421	differentiate	differentiate	VBP
422	426	into	into	IN
427	430	two	two	CD
431	442	populations	population	NNS
443	445	of	of	IN
446	454	effector	effector	NN
455	460	cells	cell	NNS
461	462	(	(	(
462	466	eTh1	eth1	NN
467	470	and	and	CC
471	475	eTh2	eth2	NN
475	476	)	)	)
476	477	,	,	,
478	482	each	each	DT
483	486	one	one	NN
487	497	expressing	express	VBG
498	499	a	a	DT
500	508	specific	specific	JJ
509	516	pattern	pattern	NN
517	519	of	of	IN
520	529	cytokines	cytokine	NNS
530	534	that	that	WDT
535	548	distinguishes	distinguish	VBZ
549	553	them	them	PRP
554	558	from	from	IN
559	564	their	their	PRP$
565	576	precursors.	precursors.	NN
577	581	eTh2	eth2	NN
582	587	cells	cell	NNS
588	591	are	be	VBP
592	595	the	the	DT
596	601	major	major	JJ
602	608	source	source	NN
609	611	of	of	IN
612	616	IL-4	il-4	NN
616	617	,	,	,
618	623	while	while	IN
624	629	gamma	gamma	NN
630	640	interferon	interferon	NN
641	643	is	be	VBZ
644	652	produced	produce	VBN
653	655	by	by	IN
656	660	eTh1	eth1	NN
661	666	cells	cell	NNS
666	667	.	.	.

668	672	Here	here	RB
673	675	we	we	PRP
676	680	have	have	VBP
681	685	used	use	VBN
686	694	reporter	reporter	NN
695	705	transgenic	transgenic	JJ
706	710	mice	mouse	NNS
711	713	to	to	TO
714	718	show	show	VB
719	723	that	that	IN
724	727	DNA	dna	NN
728	735	binding	binding	NN
736	739	and	and	CC
740	755	transcriptional	transcriptional	JJ
756	766	activities	activity	NNS
767	769	of	of	IN
770	774	NFAT	NFAT	NNP
775	778	are	be	VBP
779	790	transiently	transiently	RB
791	798	induced	induce	VBN
799	805	during	during	IN
806	809	the	the	DT
810	825	differentiation	differentiation	NN
826	828	of	of	IN
829	832	pTh	pth	NN
833	838	cells	cell	NNS
839	843	into	into	IN
844	850	either	either	CC
851	855	eTh1	eth1	NN
856	858	or	or	CC
859	863	eTh2	eth2	NN
864	869	cells	cell	NNS
870	872	to	to	TO
873	880	mediate	mediate	VB
881	884	the	the	DT
885	895	expression	expression	NN
896	898	of	of	IN
899	903	IL-2	il-2	NN
904	906	as	as	IN
907	908	a	a	DT
909	915	common	common	JJ
916	922	growth	growth	NN
923	929	factor	factor	NN
930	932	in	in	IN
933	937	both	both	DT
938	946	pathways	pathway	NNS
946	947	.	.	.

948	955	However	however	RB
955	956	,	,	,
957	965	although	although	IN
966	970	NFAT	NFAT	NNP
971	974	DNA	DNA	NNP
975	982	binding	binding	NN
983	985	is	be	VBZ
986	995	similarly	similarly	RB
996	1003	induced	induce	VBN
1004	1006	in	in	IN
1007	1011	both	both	CC
1012	1016	eTh1	eth1	NN
1017	1020	and	and	CC
1021	1025	eTh2	eth2	NN
1026	1031	cells	cell	NNS
1032	1036	upon	upon	IN
1037	1044	antigen	antigen	NN
1045	1056	stimulation	stimulation	NN
1056	1057	,	,	,
1058	1062	only	only	RB
1063	1066	the	the	DT
1067	1071	NFAT	nfat	NN
1072	1081	complexes	complex	NNS
1082	1089	present	present	JJ
1090	1092	in	in	IN
1093	1097	eTh2	eth2	NN
1098	1103	cells	cell	NNS
1104	1107	are	be	VBP
1108	1112	able	able	JJ
1113	1115	to	to	TO
1116	1123	mediate	mediate	VB
1124	1134	high-level	high-level	JJ
1135	1148	transcription	transcription	NN
1148	1149	,	,	,
1150	1153	and	and	CC
1154	1164	relatively	relatively	RB
1165	1171	little	little	JJ
1172	1176	NFAT	NFAT	NNP
1177	1192	transcriptional	transcriptional	JJ
1193	1201	activity	activity	NN
1202	1205	was	be	VBD
1206	1213	induced	induce	VBN
1214	1216	in	in	IN
1217	1221	eTh1	eth1	NN
1222	1227	cells	cell	NNS
1227	1228	.	.	.

1229	1231	In	in	IN
1232	1240	contrast	contrast	NN
1241	1243	to	to	TO
1244	1253	activated	activate	VBN
1254	1257	pTh	pth	NN
1258	1263	cells	cell	NNS
1263	1264	,	,	,
1265	1272	neither	neither	CC
1273	1277	eTh1	eth1	NN
1278	1281	nor	nor	CC
1282	1286	eTh2	eth2	NN
1287	1292	cells	cell	NNS
1293	1301	produced	produce	VBD
1302	1313	significant	significant	JJ
1314	1318	IL-2	il-2	NN
1319	1323	upon	upon	IN
1324	1335	stimulation	stimulation	NN
1335	1336	,	,	,
1337	1340	but	but	CC
1341	1344	the	the	DT
1345	1349	high	high	JJ
1350	1356	levels	level	NNS
1357	1359	of	of	IN
1360	1364	NFAT	NFAT	NNP
1365	1380	transcriptional	transcriptional	JJ
1381	1391	activities	activity	NNS
1392	1400	directly	directly	RB
1401	1410	correlate	correlate	VBP
1411	1415	with	with	IN
1416	1419	the	the	DT
1420	1424	IL-4	il-4	NN
1425	1435	production	production	NN
1436	1443	induced	induce	VBN
1444	1446	in	in	IN
1447	1455	response	response	NN
1456	1458	to	to	TO
1459	1466	antigen	antigen	NN
1467	1478	stimulation	stimulation	NN
1479	1481	in	in	IN
1482	1486	eTh2	eth2	NN
1487	1492	cells	cell	NNS
1492	1493	.	.	.

1494	1499	These	these	DT
1500	1504	data	datum	NNS
1505	1512	suggest	suggest	VBP
1513	1517	that	that	IN
1518	1527	activated	activate	VBN
1528	1532	NFAT	nfat	NN
1533	1535	is	be	VBZ
1536	1544	involved	involve	VBN
1545	1547	in	in	IN
1548	1551	the	the	DT
1552	1560	effector	effector	NN
1561	1569	function	function	NN
1570	1572	of	of	IN
1573	1577	eTh2	eth2	NN
1578	1583	cells	cell	NNS
1584	1587	and	and	CC
1588	1592	that	that	IN
1593	1596	the	the	DT
1597	1604	failure	failure	NN
1605	1607	of	of	IN
1608	1612	eTh1	eth1	NN
1613	1618	cells	cell	NNS
1619	1621	to	to	TO
1622	1629	produce	produce	VB
1630	1634	IL-4	il-4	NN
1635	1637	in	in	IN
1638	1646	response	response	NN
1647	1649	to	to	TO
1650	1652	an	an	DT
1653	1660	antigen	antigen	NN
1661	1663	is	be	VBZ
1664	1667	due	due	JJ
1667	1668	,	,	,
1669	1671	at	at	IN
1672	1677	least	least	JJS
1678	1687	partially	partially	RB
1687	1688	,	,	,
1689	1691	to	to	TO
1692	1693	a	a	DT
1694	1701	failure	failure	NN
1702	1704	to	to	TO
1705	1711	induce	induce	VB
1712	1722	high-level	high-level	JJ
1723	1736	transcription	transcription	NN
1737	1739	of	of	IN
1740	1743	the	the	DT
1744	1748	IL-4	il-4	NN
1749	1753	gene	gene	NN
1754	1756	by	by	IN
1757	1761	NFAT	NFAT	NNP
1761	1762	.	.	.

1763	1773	Regulation	Regulation	NNP
1774	1776	of	of	IN
1777	1781	NFAT	NFAT	NNP
1782	1787	could	could	MD
1788	1790	be	be	VB
1791	1800	therefore	therefore	RB
1801	1802	a	a	DT
1803	1811	critical	critical	JJ
1812	1819	element	element	NN
1820	1822	in	in	IN
1823	1826	the	the	DT
1827	1839	polarization	polarization	NN
1840	1842	to	to	TO
1843	1847	eTh1	eth1	NN
1848	1850	or	or	CC
1851	1855	eTh2	eth2	NN
1855	1856	.	.	.