0 1 c c SYM 1 2 - - : 2 5 Rel Rel NNP 6 8 is be VBZ 9 10 a a DT 11 17 target target NN 18 20 of of IN 21 44 pentoxifylline-mediated pentoxifylline-mediated JJ 45 55 inhibition inhibition NN 56 58 of of IN 59 60 T t NN 61 71 lymphocyte lymphocyte NN 72 82 activation activation NN 82 83 . . . 85 88 The the DT 89 97 possible possible JJ 98 106 clinical clinical JJ 107 110 use use NN 111 113 of of IN 114 117 the the DT 118 124 methyl methyl NN 125 133 xanthine xanthine NN 134 144 derivative derivative NN 144 145 , , , 146 160 pentoxifylline pentoxifylline NN 161 162 ( ( ( 162 164 PF PF NNP 164 165 ) ) ) 165 166 , , , 167 170 for for IN 171 174 the the DT 175 184 treatment treatment NN 185 187 of of IN 188 189 T t NN 190 204 cell-dependent cell-dependent JJ 205 213 diseases disease NNS 214 216 is be VBZ 217 222 being be VBG 223 228 noted note VBN 229 233 with with IN 234 244 increasing increase VBG 245 253 interest interest NN 253 254 . . . 255 257 In in IN 258 262 this this DT 263 268 paper paper NN 268 269 , , , 270 272 we we PRP 273 280 studied study VBD 281 284 the the DT 285 294 molecular molecular JJ 295 307 consequences consequence NNS 308 310 of of IN 311 313 PF PF NNP 314 323 treatment treatment NN 324 330 during during IN 331 341 lymphocyte lymphocyte NN 342 352 activation activation NN 352 353 . . . 354 356 We we PRP 357 362 found find VBD 363 367 that that IN 368 370 in in IN 371 372 T t NN 373 378 cells cell NNS 378 379 , , , 380 396 anti-CD3-induced anti-cd3-induced JJ 397 402 c-Rel c-rel NN 403 413 expression expression NN 414 417 was be VBD 418 425 blocked block VBN 426 428 by by IN 429 431 PF PF NNP 431 432 , , , 433 440 whereas whereas IN 441 444 the the DT 445 454 induction induction NN 455 457 of of IN 458 463 other other JJ 464 473 NF-kappaB NF-kappaB NNP 474 480 family family NN 481 488 members member NNS 489 492 was be VBD 493 496 not not RB 497 510 significantly significantly RB 511 519 affected affect VBN 519 520 . . . 521 528 However however RB 528 529 , , , 530 539 induction induction NN 540 542 of of IN 543 548 NF-AT NF-AT NNP 548 549 , , , 550 555 which which WDT 556 559 has have VBZ 560 563 the the DT 564 568 same same JJ 569 578 signaling signaling NN 579 591 requirements requirement NNS 592 594 as as IN 595 600 c-Rel c-rel NN 601 610 induction induction NN 610 611 , , , 612 615 was be VBD 616 619 not not RB 620 629 inhibited inhibit VBN 630 632 by by IN 633 635 PF PF NNP 635 636 . . . 637 642 Among among IN 643 648 genes gene NNS 649 653 that that WDT 654 661 respond respond VBP 662 664 to to TO 665 670 these these DT 671 684 transcription transcription NN 685 692 factors factor NNS 692 693 , , , 694 698 IL-2 il-2 NN 699 703 mRNA mrna NN 704 713 induction induction NN 714 717 was be VBD 718 728 suppressed suppress VBN 729 731 by by IN 732 734 PF PF NNP 734 735 , , , 736 743 whereas whereas IN 744 756 IL-2R(alpha) il-2r(alpha) NN 757 762 chain chain NN 763 767 mRNA mrna NN 768 777 induction induction NN 778 781 was be VBD 782 785 not not RB 786 794 affected affect VBN 794 795 . . . 796 801 These these DT 802 814 observations observation NNS 815 825 implicated implicate VBD 826 831 c-Rel c-rel NN 832 834 as as IN 835 837 an an DT 838 842 IL-2 il-2 NN 843 851 promoter promoter NN 852 858 factor factor NN 858 859 , , , 860 863 for for IN 864 869 which which WDT 870 882 experimental experimental JJ 883 890 support support NN 891 894 was be VBD 895 903 obtained obtain VBN 904 908 from from IN 909 918 transient transient JJ 919 931 transfection transfection NN 932 943 experiments experiment NNS 943 944 . . . 945 947 In in IN 948 956 contrast contrast NN 957 961 with with IN 962 965 the the DT 966 977 observation observation NN 978 980 in in IN 981 982 T t NN 983 988 cells cell NNS 988 989 , , , 990 995 c-Rel c-rel NN 996 1005 induction induction NN 1006 1009 was be VBD 1010 1013 not not RB 1014 1021 blocked block VBN 1022 1024 by by IN 1025 1027 PF PF NNP 1028 1030 in in IN 1031 1032 B B NNP 1033 1038 cells cell NNS 1038 1039 . . . 1040 1043 The the DT 1044 1051 greater great JJR 1052 1063 selectivity selectivity NN 1064 1066 of of IN 1067 1069 PF PF NNP 1069 1070 , , , 1071 1079 compared compare VBN 1080 1084 with with IN 1085 1090 FK506 FK506 NNP 1090 1091 , , , 1092 1094 at at IN 1095 1099 both both CC 1100 1103 the the DT 1104 1113 molecular molecular JJ 1114 1117 and and CC 1118 1126 cellular cellular JJ 1127 1133 levels level NNS 1134 1137 may may MD 1138 1143 prove prove VB 1144 1156 advantageous advantageous JJ 1157 1159 in in IN 1160 1172 manipulating manipulate VBG 1173 1174 T t NN 1175 1179 cell cell NN 1180 1189 responses response NNS 1190 1192 in in FW 1193 1197 vivo vivo FW 1197 1198 . . .